Noninvasive in vivo imaging of macrophages: understanding tumor microenvironments and delivery of therapeutics

Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 26, 2025

Abstract Macrophages are pivotal in the body’s defense and response to inflammation. They present significant numbers widely implicated various diseases, including cancer. While molecular histological techniques have advanced our understanding of macrophage biology, their precise function within cancerous microenvironments remains underexplored. Enhancing knowledge macrophages dynamics extracellular vesicles (EVs) cancer development can potentially improve therapeutic management. Notably, also been harnessed deliver drugs. Noninvasive vivo imaging is crucial for investigating intricate cellular processes, comprehending underlying mechanisms tracking cells EVs’ migration, devising macrophage-dependent drug-delivery systems living organisms. Thus, has become an indispensable tool biomedical research. The integration multimodal approaches continued novel contrast agents hold promise overcoming current limitations expanding applications imaging. This study comprehensively reviews several methods labeling modalities, assessing merits drawbacks each approach. review concludes by offering insights into applicability real time monitoring preclinical clinical scenarios.

Language: Английский

The Role of Extracellular Vesicles in Aging and Age-Related Disorders

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 177 - 177

Published: Feb. 3, 2025

A variety of molecular and cellular changes distinguish the multifaceted biological process aging. Recent studies in this decade have demonstrated essential role extracellular vesicles (EVs) aging process. Mitochondrial malfunction increased oxidative stress are major contributors for This review investigates EVs intercellular communication, tissue regeneration, inflammation context We also discuss exosome its utility to reduce stress, which is a key part aging, as well possibility using exosomes anti-aging drugs. Changes cargo composition can influence phenotype impact functionality cells tissues. Additionally, during addresses potential treatment strategies development biomarkers age-associated disorders. The highlighted providing antioxidant properties, help excessive reactive oxygen species (ROS) strengthen defenses against stress. it emphasized age-related pathologies, such neurodegenerative diseases, cardiovascular disorders, immunosenescence, offering insights into targeted interventions promoting healthy article provides comprehensive analysis current body knowledge regarding therapeutic effects on with particular emphasis implications emerging field research relationship

Language: Английский

Unlocking the Secrets of Single Extracellular Vesicles by Cutting-Edge Technologies

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 269, P. 155878 - 155878

Published: Feb. 28, 2025

Language: Английский