Psychiatry Research, Journal Year: 2022, Volume and Issue: 312, P. 114530 - 114530
Published: March 30, 2022
Language: Английский
Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(5), P. 313 - 333
Published: April 9, 2024
Language: Английский
Citations
29
Translational Psychiatry, Journal Year: 2021, Volume and Issue: 11(1)
Published: May 28, 2021
Abstract Repetitive transcranial magnetic stimulation (rTMS) has been widely used as an alternative treatment for obsessive-compulsive disorder (OCD). However, the most effective rTMS parameters, such targets and frequencies, remain controversial. Therefore, we aimed to compare rank efficacy tolerability of different strategies OCD treatment. We searched five electronic databases from date their inception March 25, 2020. Pairwise meta-analyses network were performed synthesize data. assessed quality evidence using Grading Recommendations Assessment, Development Evaluation (GRADE) framework. Twenty-two eligible randomized controlled trials (RCTs) included. For efficacy, low-frequency (LF) over dorsolateral prefrontal cortex (DLPFC; mean difference (MD) 6.34, 95% credible interval (CrI) 2.12–10.42) supplementary motor area (MD 4.18, CrI 0.83–7.62), high-frequency DLPFC 3.75, 1.04–6.81) more than sham rTMS. Regarding tolerability, all similar The estimated ranking probabilities treatments showed that LF-rTMS might be intervention among strategies. regarding was evaluated very low. Current suggested a marginal advantage on High-quality RCTs with low selection performance bias are needed further verify specific
Language: Английский
Citations
63
Neurology, Journal Year: 2022, Volume and Issue: 98(2), P. 65 - 72
Published: Jan. 10, 2022
Neuromodulation devices are approved in the United States for treatment of movement disorders, epilepsy, pain, and depression, used off-label other neurologic indications. By 2035, advances our understanding neuroanatomical networks mechanism action stimulation, coupled with developments material science, miniaturization, energy storage, delivery, will expand use neuromodulation devices. approaches flexible modifiable. Stimulation can be targeted to a dysfunctional brain focus, region, or network, delivered as single treatment, continuously, according duty cycle, response physiologic changes. Programming titrated modified based on clinical biomarker. In addition keeping pace technological developments, neurologists 2035 need navigate complex ethical economic considerations ensure access technology rapidly expanding population patients. This article provides an overview systems today those that anticipated highlights opportunities challenges future, some which technical, but most addressed by learning about networks, from growing experience
Language: Английский
Citations
48
IEEE Journal of Microwaves, Journal Year: 2022, Volume and Issue: 3(1), P. 134 - 169
Published: Dec. 19, 2022
Advances
and
updates
in
medical
applications
utilizing
microwave
techniques
technologies
are
reviewed
this
paper.
The
article
aims
to
provide
an
overview
of
enablers
for
their
recent
progress.
emphasis
focuses
on
the
microwaves,
following
order,
1)
signal
data
communication
implants
wearables
through
human
body,
2)
electromagnetic
energy
transfer
tissues,
3)
noninvasive,
remote
or
Language: Английский
Citations
39
Frontiers in Neurology, Journal Year: 2022, Volume and Issue: 13
Published: Aug. 9, 2022
Early research into neural correlates of obsessive compulsive disorder (OCD) has focused on individual components, several network-based models have emerged from more recent data dysfunction within brain networks, including the lateral orbitofrontal cortex (lOFC)-ventromedial caudate, limbic, salience, and default mode networks. Moreover, interplay between multiple networks been increasingly recognized. As understanding circuitry underlying pathophysiology OCD continues to evolve, so will too our ability specifically target these using invasive noninvasive methods. This review discusses rationale for theory behind neuromodulation in treatment OCD.
Language: Английский
Citations
24
Bioelectronic Medicine, Journal Year: 2023, Volume and Issue: 9(1)
Published: Nov. 22, 2023
Gastrointestinal (GI) disorders, which extend from the esophagus to anus, are most common diseases of GI tract. Among these pain, encompassing both abdominal and visceral is a predominant feature, affecting patients' quality life imposing substantial financial burden on society. Pain signals originating gut intricately shape brain dynamics. In response, sends appropriate descending respond pain through neuronal inhibition. However, due heterogeneous nature disease its limited pathophysiological understanding, treatment options minimal often controversial. Consequently, many patients with disorders use complementary alternative therapies such as neuromodulation treat pain. Neuromodulation intervenes in central, peripheral, or autonomic nervous system by alternating modulating nerve activity using electrical, electromagnetic, chemical, optogenetic methodologies. Here, we review few emerging noninvasive approaches promising potential for alleviating associated functional dyspepsia, gastroparesis, irritable bowel syndrome, inflammatory disease, non-cardiac chest Moreover, address critical aspects, including efficacy, safety, feasibility methods, elucidate their mechanisms action, outline future research directions. conclusion, field appears viable therapeutic avenue effectively managing disorders.
Language: Английский
Citations
15
Materials Today Bio, Journal Year: 2023, Volume and Issue: 22, P. 100784 - 100784
Published: Aug. 29, 2023
Smart implants are increasingly used to treat various diseases, track patient status, and restore tissue organ function. These devices support internal organs, actively stimulate nerves, monitor essential functions. With continuous monitoring or stimulation, observation quality subsequent treatment can be improved. Additionally, using biodegradable entirely excreted implant materials eliminates the need for surgical removal, providing a patient-friendly solution. In this review, we classify smart discuss latest prototypes, materials, technologies employed in their creation. Our focus lies exploring medical beyond replacing an incorporating new functionality through sensors electronic circuits. We also examine advantages, opportunities, challenges of creating implantable that preserve all critical By presenting in-depth overview current state-of-the-art implants, shed light on persistent issues limitations while discussing potential avenues future advancements these devices.
Language: Английский
Citations
14
Journal of the Neurological Sciences, Journal Year: 2023, Volume and Issue: 456, P. 122825 - 122825
Published: Dec. 10, 2023
Non-invasive brain stimulation (NIBS) techniques have a rich historical background, yet their utilization has witnessed significant growth only recently. These encompass transcranial electrical and magnetic stimulation, which were initially employed in neuroscience to explore the intricate relationship between behaviour. However, they are increasingly finding application research contexts as means address various neurological, psychiatric, neurodegenerative disorders. This article aims fulfill two primary objectives. Firstly, it seeks showcase current state of art clinical NIBS, highlighting how can improve complement existing treatments. Secondly, provides comprehensive overview NIBS augmenting function healthy individuals, thereby enhancing performance. Furthermore, delves into points convergence divergence these techniques. It also addresses challenges future prospects associated with from ethical standpoints.
Language: Английский
Citations
13
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Sept. 4, 2023
Deep-brain stimulation (DBS) is an effective treatment for patients suffering from otherwise therapy-resistant psychiatric disorders, including obsessive-compulsive disorder. Modulation of cortico-striatal circuits has been suggested as a mechanism action. To gain mechanistic insight, we monitored neuronal activity in regions mouse model compulsive behavior, while systematically varying clinically-relevant parameters internal-capsule DBS. DBS showed dose-dependent effects on both brain and behavior: An increasing, yet balanced, number excited inhibited neurons was recruited, scattered throughout regions, excessive grooming decreased. Such recruitment did not alter basic function such resting-state activity, only occurred awake animals, indicating dependency network activity. In addition to these widespread effects, observed specific involvement the medial orbitofrontal cortex therapeutic outcomes, which corroborated by optogenetic stimulation. Together, our findings provide insight into how exerts its behaviors.
Language: Английский
Citations
11
Molecular Psychiatry, Journal Year: 2022, Volume and Issue: 27(12), P. 5206 - 5212
Published: Sept. 7, 2022
Language: Английский
Citations
18