Exploring the neurobiological correlates of psilocybin-assisted psychotherapy in eating disorders: a review of potential methodologies and implications for the psychedelic study design DOI Creative Commons
Elena Koning, Cristiano Chaves, Ryan H. Kirkpatrick

et al.

Journal of Eating Disorders, Journal Year: 2024, Volume and Issue: 12(1)

Published: Dec. 27, 2024

Eating disorders (EDs) are a group of debilitating mental illnesses characterized by maladaptive eating behaviors and severe cognitive-emotional dysfunction, directly affecting 1–3% the population. Standard treatments not effective in approximately one third ED cases, representing need for scientific advancement. There is emerging evidence safety efficacy psilocybin-assisted psychotherapy (PAP) to improve treatment outcomes individuals with EDs. However, limited knowledge neurobiological mechanisms underlying therapeutic effects PAP restricts ability confirm its clinical utility. This narrative review presents an overview methodologies used elucidate pathophysiological EDs or psilocybin that could be employed probe correlates EDs, including magnetic resonance imaging molecular neuroimaging techniques, electrophysiological approaches, neuroplasticity markers. Finally, implications these described relation unique features psychedelic study design, challenges, limitations, future directions advance field. paper represents valuable resource scientists during conceptualization design phases stimulates advancement identification interventions serious health conditions impact behaviors, thoughts, emotions, up 3% people worldwide. Current about highlighting new approaches. Psilocybin-assisted option shows promise improving there lack understanding which may support recovery, making it difficult benefits. several research methods help uncover how influences brain approaches The challenges incorporating into also discussed. Together, this advancements development more

Language: Английский

Exploring the neurobiological correlates of psilocybin-assisted psychotherapy in eating disorders: a review of potential methodologies and implications for the psychedelic study design DOI Creative Commons
Elena Koning, Cristiano Chaves, Ryan H. Kirkpatrick

et al.

Journal of Eating Disorders, Journal Year: 2024, Volume and Issue: 12(1)

Published: Dec. 27, 2024

Eating disorders (EDs) are a group of debilitating mental illnesses characterized by maladaptive eating behaviors and severe cognitive-emotional dysfunction, directly affecting 1–3% the population. Standard treatments not effective in approximately one third ED cases, representing need for scientific advancement. There is emerging evidence safety efficacy psilocybin-assisted psychotherapy (PAP) to improve treatment outcomes individuals with EDs. However, limited knowledge neurobiological mechanisms underlying therapeutic effects PAP restricts ability confirm its clinical utility. This narrative review presents an overview methodologies used elucidate pathophysiological EDs or psilocybin that could be employed probe correlates EDs, including magnetic resonance imaging molecular neuroimaging techniques, electrophysiological approaches, neuroplasticity markers. Finally, implications these described relation unique features psychedelic study design, challenges, limitations, future directions advance field. paper represents valuable resource scientists during conceptualization design phases stimulates advancement identification interventions serious health conditions impact behaviors, thoughts, emotions, up 3% people worldwide. Current about highlighting new approaches. Psilocybin-assisted option shows promise improving there lack understanding which may support recovery, making it difficult benefits. several research methods help uncover how influences brain approaches The challenges incorporating into also discussed. Together, this advancements development more

Language: Английский

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