Targets, Journal Year: 2025, Volume and Issue: 3(1), P. 11 - 11
Published: March 11, 2025
The quantification of endocannabinoids in biological fluids is becoming increasingly popular as an indicator psychological and physiological function. Numerous methods to quantify the endocannabinoid ligands have been published so far, yet their concentrations responses often exhibit significant variability across studies. Endocannabinoids regulate interact with a wide range biomolecules, causing vary between cohorts individuals, sensitivities them depend on pre-experimental behaviours activities. Moreover, matrix effects produced by complex nature biofluids necessitate rigorous sample preparation techniques, all which introduce opportunities for both inter- intra-assay variability. This review aims address causes prior mass spectrometric analysis, including biofluid choice, human variability, collection extraction methods. If these factors are fully considered standardised introduced, may become more reliable, allowing utility clinical markers progress.
Language: Английский