Compulsive-Like Responding for Opioid Analgesics in Rats with Extended Access

Neuropsychopharmacology, Journal Year: 2014, Volume and Issue: 40(2), P. 421 - 428

Published: July 25, 2014

Language: Английский

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Abuse and misuse of antidepressants

Substance Abuse and Rehabilitation, Journal Year: 2014, Volume and Issue: unknown, P. 107 - 107

Published: Aug. 1, 2014

Background: Rates of prescription drug abuse have reached epidemic proportions. Large-scale epidemiologic surveys this under-recognized clinical problem not included antidepressants despite their contribution to morbidity and mortality. The purpose review is look specifically at the misuse how behavior may fit into growing crisis nonmedical use drugs. Methods: We conducted a comprehensive search on PubMed, Medline, PsycINFO using terms "antidepressant", "abuse", "misuse", "nonmedical use", "dependence", "addiction", as well individual antidepressant classes (eg, "SSRI") "fluoxetine") in various combinations, identify articles abuse. Results: A small but literature consists largely case reports. Most cases occurred individuals with comorbid substance mood disorders. most commonly reported motivation for achieve psychostimulant-like effect. Antidepressants are abused high doses via variety routes administration intranasal, intravenous). Negative consequences vary based upon class pharmacology, these seizures, confusion, psychotic-like symptoms. Conclusion: majority prescribed do medication. However, certain carry potential. Vulnerable patient populations include those history controlled environments. Warning signs presence aberrant behaviors. Physicians should when screening risky medication use. When detected, thoughtful treatment plan, including referral an addiction specialist, be developed implemented. Keywords: antidepressant, prescription, misuse, abuse, use, dependence,

Language: Английский

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Phubbing and its impact on the individual's psychological well-being

Acta Psychologica, Journal Year: 2024, Volume and Issue: 248, P. 104388 - 104388

Published: July 3, 2024

Increasingly, smartphones have become a part of people's everyday lives, and are now considered by many to be an indispensable social accessory. Since attachment smartphone could negative psychological consequences, burgeoning new area research has emerged which examines the effects on individuals' well-being. Hence, this study focuses phubbing - one's engagement with during face-to-face conversation another person or group people its association For investigation, quantitative descriptive approach been adopted involving sample 370 women men from Spain between 25 60 years old. The survey was distributed late 2019 first quarter 2020. Phubbing Behaviors Survey conducted, comprising five dimensions (cultural, technological, social, communicational, psychological), total 33 items requiring responses 5-point Likert scale. This used in conjunction General Health Questionnaire (GHQ-28), consisting four categories (somatic symptoms, dysfunction, anxiety insomnia, severe depression), 7 per category. findings reveal positive correlation depression and, young under old show higher levels somatic symptoms than same age group. demonstrates need raise awareness via health education promote healthy use Internet prevent distress resulting phubbing.

Language: Английский

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NIAAA and the Global Challenge: An Interview with Dr. Margaret (Peggy) Murray, Director, Global Alcohol Research Program, National Institutes of Health, National Institute of Alcohol Abuse and Alcoholism

Journal of Social Work Practice in the Addictions, Journal Year: 2017, Volume and Issue: 17(1-2), P. 216 - 223

Published: April 3, 2017

Language: Английский

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The effect of propofol on mental health in Saudi Arabia

International Journal of Community Medicine and Public Health, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Propofol is a widely used intravenous anesthetic agent with rapid onset and short duration of action. While extensively utilized for sedation anesthesia, recent research has raised concerns regarding its impact on mental health, particularly addiction potential, hormonal effects, neuropsychiatric implications in individuals underlying neurological conditions. This review aims to examine the neurobiological, hormonal, psychiatric effects propofol focus mechanisms, role neurodevelopmental neurodegenerative syndromes, modulation stress- mood-related hormones, especially within healthcare landscape Saudi Arabia. A comprehensive literature was conducted, drawing from experimental studies, clinical trials, pharmacological analyses that explored propofol’s interaction dopamine pathways, hormone regulation, syndromes such as Down syndrome, fragile X syndrome (FXS), Tourette (TS). Propofol’s mesolimbic system transporter (DAT) contributes addictive properties. It alters responses by modulating GABAergic reducing stress levels cortisol epinephrine. In patients specific demonstrates differential cognition, recovery, activity, requiring tailored considerations. remains cornerstone modern psychoactive among professionals, necessitates stricter regulation education. Its health highlights dual therapeutic promise risk, warranting further policy development, Arabia, where regulatory oversight limited.

Language: Английский

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On the positive and negative affective responses to cocaine and their relation to drug self-administration in rats

Psychopharmacology, Journal Year: 2015, Volume and Issue: 232(13), P. 2363 - 2375

Published: Feb. 6, 2015

Language: Английский

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Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys

Psychopharmacology, Journal Year: 2017, Volume and Issue: 234(17), P. 2607 - 2617

Published: June 5, 2017

Language: Английский

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Simulating Patterns of Heroin Addiction Within the Social Context of a Local Heroin Market

Springer eBooks, Journal Year: 2011, Volume and Issue: unknown, P. 313 - 331

Published: Oct. 25, 2011

Language: Английский

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α7 Nicotinic acetylcholine receptors in the central amygdaloid nucleus alter naloxone-induced withdrawal following a single exposure to morphine

Psychopharmacology, Journal Year: 2010, Volume and Issue: 214(4), P. 923 - 931

Published: Dec. 1, 2010

Language: Английский

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Sigma Receptors and Alcohol Use Disorders

Handbook of experimental pharmacology, Journal Year: 2016, Volume and Issue: unknown, P. 219 - 236

Published: Jan. 1, 2016

Language: Английский

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