Exploration of Neuroprotective Therapy, Journal Year: 2024, Volume and Issue: unknown, P. 198 - 239
Published: May 15, 2024
Transmethylation in the context of psychiatry has historically referred to enzymatic transfer a methyl group from one biochemical another, whose resulting function can change so dramatically that like tryptamine, for example, is converted into hallucinogen dimethyltryptamine. Central endogenous methylation activity folate cycle, which generates primary transferable groups mammalian biochemistry. The relevance this cycle mental health becomes clear when dysregulated, often leading buildup both homocysteine and S-adenosylhomocysteine (SAH), while accompanied by transient reduction intended physiologic target, S-adenosylmethionine (SAM). This paper includes an in-depth review causes perturbations associated with psychotic symptoms, expounding on alternative downstream pathways are activated pointing toward potential etiologic agents psychosis, methylated tertiary amines N-methyl-salsolinol, N-methyl-norsalsolinol, adrenochrome, appear scientific reports concerning their association hallucinogenic and/or neurotoxic outcomes. Electrotopological state (E-state) data been generated these compounds, illustrating strong similarity hallucinogens, particularly terms E-state nitrogen amine moieties. In light role plays transmethylation, neuroprotective strategies prevent transition psychosis suggested, including advisory supplementation be harmful depending status other relevant biochemicals.
Language: Английский