Targeting organ-specific mitochondrial dysfunction to improve biological aging

Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 262, P. 108710 - 108710

Published: Aug. 22, 2024

In an aging society, unveiling new anti-aging strategies to prevent and combat aging-related diseases is of utmost importance. Mitochondria are the primary ATP production sites key regulators programmed cell death. Consequently, these highly dynamic organelles play a central role in maintaining tissue function, mitochondrial dysfunction pivotal factor progressive age-related decline cellular homeostasis organ function. The current review examines recent advances understanding interplay between organ-specific aging. Thereby, we dissect molecular mechanisms underlying impairment associated with deterioration exploring DNA, reactive oxygen species homeostasis, metabolic activity, damage-associated patterns, biogenesis, turnover, dynamics. We also highlight emerging therapeutic preclinical clinical tests that supposed rejuvenate such as antioxidants, biogenesis stimulators, modulators turnover Furthermore, discuss potential benefits challenges use interventions, emphasizing need for approaches given unique characteristics different tissues. conclusion, this highlights addressing mitigate aging, focusing on skin, liver, lung, brain, skeletal muscle, well reproductive, immune, cardiovascular systems. Based comprehensive multifaceted roles mitochondria, innovative may be developed optimized biological promote healthy across diverse

Language: Английский

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Sex differences in airway disease: estrogen and airway surface liquid dynamics

Biology of Sex Differences, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 18, 2024

Abstract Biological sex differences exist for many airway diseases in which females have either worse or better health outcomes. Inflammatory such as cystic fibrosis (CF) and asthma display a clear male advantage post-puberty while female benefit is observed during the pre-puberty years. The influence of menstrual cycle stage pregnancy on frequency severity pulmonary exacerbations CF point to role steroid hormones, particularly estrogen, underpinning biological these diseases. There are ways by estrogen may aggravate involving disturbances surface liquid (ASL) dynamics, inappropriate hyper-immune allergenic responses, well exacerbation pathogen virulence. deleterious effect function contrasts with characterised edema pneumonia, acute respiratory distress syndrome (ARDS) COVID-19. Airway hypersecretion alveolar flooding hallmarks ARDS COVID-19, contribute morbidity mortality severe forms ASL dynamics encompasses intrinsic features thin lining fluid covering epithelium regulate mucociliary clearance (ciliary beat, height, volume, pH, viscosity, mucins, channel activating proteases) addition innate defence mechanisms (pathogen virulence, cytokines, defensins, specialised pro-resolution lipid mediators, metabolism). Estrogen regulation contributing CF, COVID-19 major focus this review. Graphical

Language: Английский

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Sex Differences in Airway Remodeling and Inflammation: Clinical and Biological Factors

Frontiers in Allergy, Journal Year: 2022, Volume and Issue: 3

Published: April 29, 2022

Asthma is characterized by an increase in the contraction and inflammation of airway muscles, resulting airflow obstruction. The prevalence asthma lower females than males until start puberty, higher adult women men. This sex disparity switch at onset puberty has been object debate among many researchers. Hence, this review, we have summarized these observations to pinpoint areas needing more research work provide better sex-specific diagnosis management asthma. While some researchers attributed it anatomical physiological differences male female respiratory systems, influences hormonal interplay after also stressed. Other hormones such as leptin linked both obese non-obese patients. Recently, scientists demonstrated influence genomic framework a key player, others environmental, social lifestyle, occupational exposures. majority studies concluded that men are less susceptible developing display severe forms disease. Therefore, understanding roles played sex- gender-specific factors, biological mechanisms involved will help develop novel accurate diagnostic therapeutic plans for management.

Language: Английский

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Descriptive and Functional Genomics in Neonatal Respiratory Distress Syndrome: From Lung Development to Targeted Therapies

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(1), P. 649 - 649

Published: Jan. 4, 2024

In this up-to-date study, we first aimed to highlight the genetic and non-genetic factors associated with respiratory distress syndrome (RDS) while also focusing on genomic aspect of condition. Secondly, discuss treatment options progressing therapies based RNAs or gene therapy. To fulfill this, our study commences lung organogenesis, a highly orchestrated procedure guided by an intricate network conserved signaling pathways that ultimately oversee processes patterning, growth, differentiation. Then, review focuses molecular mechanisms contributing both normal abnormal growth development underscores connections between linked neonatal RDS, particular emphasis aspects condition their implications for choices advancing therapeutic approaches centered around

Language: Английский

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Identification of Asthma Phenotypes in the Spanish MEGA Cohort Study Using Cluster Analysis

Archivos de Bronconeumología, Journal Year: 2023, Volume and Issue: 59(4), P. 223 - 231

Published: Jan. 18, 2023

Language: Английский

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Promising Intestinal Microbiota Associated with Clinical Characteristics of COPD Through Integrated Bioinformatics Analysis

International Journal of COPD, Journal Year: 2024, Volume and Issue: Volume 19, P. 873 - 886

Published: April 1, 2024

Introduction: Chronic obstructive pulmonary disease (COPD), an incurable chronic respiratory disease, has become a major public health problem.The relationship between the composition of intestinal microbiota and important clinical factors affecting COPD remains unclear.This study aimed to identify specific with high diagnostic value for COPD.Methods: The fecal patients healthy individuals were analyzed by 16S rDNA sequencing.Random forest classification was performed analyze different microbiota.Spearman correlation conducted characteristics.A microbiota-disease network diagram constructed using gut MDisorder database possible pathogenesis microorganisms COPD, screen potential treatment, guide future research.Results: No significant difference in biodiversity shown two groups but differences microbial community structure.Fifteen genera bacteria large abundance identified, including Bacteroides, Prevotella, Lachnospira, Parabacteroides.Among them, relative Lachnospira Coprococcus negatively related smoking index positively lung function results.By contrast, Parabacteroides correlated findings.Random showed that genus most capable distinguishing suggesting it may be biomarker COPD.A suggested decreased some diseases, such as asthma, diabetes mellitus, coronavirus 2019 (COVID-19), increased other irritable bowel syndrome, hypertension, bovine lichen. Conclusion:The dominant is characteristics COPD.

Language: Английский

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A Serological identification of anti-adenovirus antibodies in children with respiratory infection under five years in Nasiriyah city,Iraq.

NTU Journal of Pure Sciences, Journal Year: 2025, Volume and Issue: 3(4)

Published: Jan. 1, 2025

Childhood respiratory tract infections are serious and dangerous clinical forms that occur around the world, adenoviruses represent one of most significant viruses cause these in children. The three species B, C, E adenovirus mostly responsible for infections. In addition, rapid identification is absolutely necessary to prevent overuse antibiotics patients, a local epidemic adenoviruses, treat severe may fatal disease. current study was designed detect prevalence antibodies children Nasiriyah city ,Iraq . For this reason, blood samples were collected from August 2022 May 2023 patients less than five years old who hospitalized at Muhammad Al-Musawi Bint Al-Huda hospitals. obtained fifty infected with ARTI. Concerning immunosuppressed conditions, underlying illnesses, persistent pulmonary abnormalities, they prohibited. All individuals investigated detection Adenovirus-IgM IgG using enzyme-linked immunosorbent assay (ELISA). Igm found 9 percent highest rate males 24 (29.17%), compared females 2 (7.69%), age group 1 day–12 month 58.33 percent. results statistically (p < 0.05). higher 23 (46%) (66.67%) (26.92%), 37–60 months (64.0%), while lowest groups 1–12 (8.33%).

Language: Английский

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Analysis of sex-specific disease patterns associated with human lifespan

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract Disability and multimorbidity increase with aging constitute a challenge for the health system. However, different individuals display trajectories, understanding underlying relationships between lifespan disease is fundamental identifying patterns in human lifespan. A previous study explored associations age of onset diseases organ systems, prevalence escapers, percentage life free (health span), comparing them genders Catalonian population. In this retrospective study, we analyzed cohort 41,063 old (20,722 men, mean 79 years [50–109], 20,341 women, 84 [50–109]) deceased 2014 2019 Gipuzkoa (Basque Country, Spain) taken from Basque Health Service electronic records data lake contrasted above cited characteristics. Longevity, defined by population, showed protective effect against developing diseases, higher lifespans delaying all both at single multisystemic levels. Furthermore, lowest highest were ones presenting healthier profiles, fewer systems altered. There specific differences according to sex, women exhibiting decreased mortality risk despite having greater men less multimorbidity. addition, reached smaller number comorbidities. These results define trajectories extend characterization aging, provide insight into sex-specific survival risk.

Language: Английский

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Mortalidade em internações por Pneumonia em crianças e adolescentes mato-grossenses no período de 2013 a 2023

Research Society and Development, Journal Year: 2025, Volume and Issue: 14(1), P. e5214148039 - e5214148039

Published: Jan. 15, 2025

Objetivo: Analisar a mortalidade decorrente de internações por pneumonia entre crianças e adolescentes residentes no estado Mato Grosso período 2013 2023. Método: Trata-se um estudo ecológico, com delineamento temporal, baseado em dados secundários obtidos do SIH-DATASUS, abrangendo notificações janeiro dezembro Foram incluídos indivíduos idade inferior 1 ano até 19 anos. As variáveis analisadas foram: sexo, faixa etária, cor/raça, caráter atendimento, estabelecimento, macrorregião saúde, ano/mês processamento, média permanência óbitos. Resultados: registradas 61.918 Grosso, 440 óbitos hospitalares, representando uma mensal 3,33 Crianças menores concentraram 43,4% das mortes. O mês abril apresentou o maior número óbitos, 54 registros taxa letalidade 0,74%. A meninos foi 25,64% comparação às meninas. Em 2022, os superaram anos incidência pneumonia, possivelmente devido à redução da imunidade inata pelo menor contato pneumococo durante isolamento social na pandemia. Conclusão: seus desfechos mais graves afetam principalmente ano, sexo masculino. Dessa forma, destaca-se relevância medidas protetoras, como atualização calendário vacinal incentivo ao aleitamento materno, estratégias fundamentais para diminuir elevada observada estado.

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Sex-Specific Effects of Environmental Pollutants on Pulmonary Immune Responses

Current Opinion in Physiology, Journal Year: 2025, Volume and Issue: 43, P. 100813 - 100813

Published: Jan. 18, 2025

Language: Английский

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