Re-Assessing the Role of Platelet Activating Factor and Its Inflammatory Signaling and Inhibitors in Cancer and Anti-Cancer Strategies

Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(10)

Published: Sept. 26, 2024

Since 2000s, we have outlined the multifaceted role of inflammation in several aspects cancer, via specific inflammatory mediators, including platelet activating factor (PAF) and PAF-receptor (PAFR) related signaling, which affect important junctions cellular interactions that are associated with tumor-related manifestations. It is now well established disease-related unresolved chronic responses can promote carcinogenesis. At same time, tumors themselves able to their progression metastasis, by triggering an inflammation-related vicious cycle, PAF its signaling play crucial role(s), usually conclude tumor growth angiogenesis. In parallel, new evidence suggests also interact cancer treatments inducing antitumor immune response or, conversely, promoting recurrence. Within this review article, current knowledge future perspectives implication all these thoroughly re-assessed. The potential beneficial PAF-inhibitors natural or synthetic modulators PAF-metabolism against tumors, metastasis evaluated. Emphasis given molecules dual anti-PAF anti-cancer activities (Bio-DAPAC-tives), proven potency through clinical trials, as on metal-based anti-inflammatory mediators constitute a class potent inhibitors. way compounds may anti-tumor effects modulate actions discussed. Limitations targeting PAF, metabolism receptor, PAF-related part(s) strategies involve response(s) for improved outcome,

Language: Английский

Anti-inflammatory, antithrombotic and anti-oxidant bioactives of beer and brewery by-products, as ingredients of bio-functional foods, nutraceuticals, cosmetics, cosmeceuticals and pharmaceuticals with health promoting properties

AIMS Agriculture and Food, Journal Year: 2024, Volume and Issue: 9(2), P. 568 - 606

Published: Jan. 1, 2024

<abstract> <p>Fermented alcoholic beverages and their by-products, including beer breweries' bio-wastes like spent yeasts, grain, hops, contain a plethora of natural bioactive compounds that have recently gained attention for valorization as functional ingredients in several novel foods nutraceuticals, well drugs cosmetics applications. Within this article, the bio-functional fermented product by-products with anti-inflammatory, antithrombotic, anti-oxidant bioactivities are thoroughly reviewed. The important roles yeasts involved such bioactives to be present brewery also outlined. health promoting benefits moderate consumption resulting from these bioactives, part balanced diet, against inflammation-related chronic disorders is discussed, along detrimental effects abuse potential alternative non-alcoholic beers. mechanisms action synergism anti-thrombotic, antioxidant properties presented. Current research future perspectives on valorizing grain hops health-promoting foods, supplements, nutraceuticals cosmetics, cosmeceuticals, pharmaceuticals evaluated, while limitations use discussed.</p> </abstract>

Language: Английский