Phytochemicals Targeting BDNF Signaling for Treating Neurological Disorders DOI Creative Commons
Alka Ashok Singh,

Sadhana Katiyar,

Minseok Song

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 252 - 252

Published: Feb. 27, 2025

Neurological disorders are defined by a deterioration or disruption of the nervous system’s structure and function. These diseases, which include multiple sclerosis, Alzheimer’s disease, Parkinson’s Huntington’s schizophrenia, caused intricate pathological processes that excitotoxicity, neuroinflammation, oxidative stress, genetic mutations, compromised neurotrophic signaling. Although current pharmaceutical treatments relieve symptoms, their long-term efficacy is limited due to adverse side effects weak neuroprotective properties. However, when combined with other drugs adjunct therapy, they may offer additional benefits improve treatment outcomes. Phytochemicals have emerged as attractive therapeutic agents ability regulate essential pathways, especially brain-derived factor (BDNF) signaling cascade. BDNF an important target for neurodegenerative disease (ND) since it regulates neuronal survival, synaptic plasticity, neurogenesis, neuroprotection. This review emphasizes molecular pathways through various phytochemicals—such flavonoids, terpenoids, alkaloids, phenolic compounds—stimulate expression modulate its downstream including GSK-3β, MAPK/ERK, PI3K/Akt/mTOR, CREB, Wnt/β-catenin. paper also highlights how phytochemical combinations interact enhance activity, offering new options ND treatment. Despite potential neuroprotection, phytochemicals face challenges related pharmacokinetics, blood–brain barrier (BBB) permeability, absorption, highlighting need further research into combination therapies improved formulations. Clinical assessment mechanistic understanding BDNF-targeted phytotherapy should be main goals future studies. The natural compounds in regulating highlighted this review, providing viable approach prevention NDs.

Language: Английский

Phytochemicals Targeting BDNF Signaling for Treating Neurological Disorders DOI Creative Commons
Alka Ashok Singh,

Sadhana Katiyar,

Minseok Song

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 252 - 252

Published: Feb. 27, 2025

Neurological disorders are defined by a deterioration or disruption of the nervous system’s structure and function. These diseases, which include multiple sclerosis, Alzheimer’s disease, Parkinson’s Huntington’s schizophrenia, caused intricate pathological processes that excitotoxicity, neuroinflammation, oxidative stress, genetic mutations, compromised neurotrophic signaling. Although current pharmaceutical treatments relieve symptoms, their long-term efficacy is limited due to adverse side effects weak neuroprotective properties. However, when combined with other drugs adjunct therapy, they may offer additional benefits improve treatment outcomes. Phytochemicals have emerged as attractive therapeutic agents ability regulate essential pathways, especially brain-derived factor (BDNF) signaling cascade. BDNF an important target for neurodegenerative disease (ND) since it regulates neuronal survival, synaptic plasticity, neurogenesis, neuroprotection. This review emphasizes molecular pathways through various phytochemicals—such flavonoids, terpenoids, alkaloids, phenolic compounds—stimulate expression modulate its downstream including GSK-3β, MAPK/ERK, PI3K/Akt/mTOR, CREB, Wnt/β-catenin. paper also highlights how phytochemical combinations interact enhance activity, offering new options ND treatment. Despite potential neuroprotection, phytochemicals face challenges related pharmacokinetics, blood–brain barrier (BBB) permeability, absorption, highlighting need further research into combination therapies improved formulations. Clinical assessment mechanistic understanding BDNF-targeted phytotherapy should be main goals future studies. The natural compounds in regulating highlighted this review, providing viable approach prevention NDs.

Language: Английский

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