Anti-cancer potential of hydroethanolic extracts of Kyllinga nemoralis: an in vitro and in-silico studies

Pharmacological Research - Natural Products, Journal Year: 2025, Volume and Issue: 6, P. 100161 - 100161

Published: Jan. 31, 2025

Language: Английский

---

SOCIOECONOMIC AND CULTURAL FACTORS INFLUENCING TRADITIONAL MEDICINE (TM) USE IN NIGERIA: A SYSTEMATIC MIXED METHOD REVIEW.

European Journal of Integrative Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 102436 - 102436

Published: Feb. 1, 2025

Language: Английский

---

From Killer to Solution: Evaluating Bioremediation Strategies on Microbial Diversity in Crude Oil-Contaminated Soil over Three to Six Months in Port Harcourt, Nigeria

Advances in Environmental and Engineering Research, Journal Year: 2024, Volume and Issue: 05(04), P. 1 - 26

Published: Nov. 5, 2024

The study aimed to evaluate the efficacy of various bioremediation approaches on microbial diversity in crude oil-contaminated soil over three six months Port Harcourt, Nigeria. objective was assess impact different strategies populations, particularly focusing hydrocarbon-utilizing bacteria and fungi. Microbial populations were quantified using serial dilution count techniques. vapor phase transfer mechanism employed estimate Bacterial fungal colonies incubated for five days, followed by biochemical tests isolate identification. Fungal pure cultures observed under a microscope. significant increase free oil pollution when bioremediators such as mushrooms earthworms introduced. Mushrooms exhibited 50% (HUB), while showed 55% HUB six-month period. longer lifespan nutrient absorption capabilities facilitated faster growth. Furthermore, growth population fungi oil-polluted after employing bioremediation, with highest treated at months, months. Conversely, lowest recorded polluted 10% remediated results suggest that effectively soil. However, demonstrated higher compared earthworms, especially terms promoting (HUB) (HUF). Based findings, it is recommended prioritize agents similar environmental restoration efforts due their superior increasing HUF. This underscores potential effective restoring soil, offering insights sustainable practices oil-affected regions like

Language: Английский

---

Investigating Potential Anti-Bacterial Natural Products Based on Ayurvedic Formulae Using Supervised Network Analysis and Machine Learning Approaches

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 192 - 192

Published: Jan. 30, 2025

Objectives: This study implements a multi-dimensional methodology to systematically identify potential natural antibiotics derived from the medicinal plants utilized in Ayurvedic practices. Methods: Two primary analytical techniques are employed explore antibiotic of plants. The initial approach utilizes supervised network analysis, which involves application distance measurement algorithms scrutinize interconnectivity and relational patterns within formulae. Results: 39 candidate with properties were identified. second leverages advanced machine learning techniques, particularly focusing on feature extraction pattern recognition. yielded list 32 exhibiting characteristics indicative antibiotics. A key finding this research is identification 17 that consistently recognized by both methods. These well-documented existing literature for their antibacterial properties, either directly or through bioactive compounds, suggests strong validation study’s methodology. By synergizing analysis learning, provides rigorous multi-faceted examination plants, significantly contributing candidates. Conclusions: not only reinforces traditional medicine as source new therapeutics but also demonstrates effectiveness combining classical contemporary complex biological datasets.

Language: Английский

---

Comparative analysis of phytochemical and antioxidant potential in traditional medicinal plants: Insights from solvent-based extractions

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106603 - 106603

Published: April 1, 2025

Language: Английский

---

Nanoformulations of Isoflavones: Mechanistic insights and Translational research

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106948 - 106948

Published: April 1, 2025

Language: Английский

---

Protective effect of Spondias mombin leaf extracts against aluminum chloride-induced brain oxidative stress, inflammation and apoptosis in rats

Future Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 23, 2025

Abstract Background Aluminum is recognized for its toxicity in humans and animals. This study investigates the protective effects of Spondias mombin leaf extracts against oxidative stress, inflammation, apoptosis male Wistar rats. Rats were divided into nine groups, receiving 100 mg/kg AlCl 3 weeks, followed by a 2-week treatment with extract (SME) or fraction (SMF) at 200 mg/kg. Brain tissues analyzed using biochemical, molecular, histopathological techniques. Results Phytochemical analysis confirmed presence tannins, phenols, terpenoids, flavonoids steroids, while HPLC identified kaempferol other polyphenols, extracts. exposure led to increased inflammatory damage brain tissue as revealed decreased glutathione concentrations antioxidant enzyme activities, along elevated levels tumor necrosis factor-alpha, nitric oxide, myeloperoxidase, xanthine oxidase, lactate dehydrogenase. Caspase-3, BCL2 associated X (Bax) also -exposed Both SME SMF mitigated -induced redox imbalance, proinflammatory events, neuronal cell death enhancing reduced reducing biomarkers, preserving hippocampal formation organization. Conclusions These findings highlight therapeutic potential aluminum-induced neurotoxic through their antioxidant, anti-inflammatory, antiapoptotic properties. Graphical abstract

Language: Английский

---