Review of electrophysiological models to study membrane potential changes in breast cancer cell transformation and tumor progression DOI Creative Commons
Chitaranjan Mahapatra,

A. Kishore,

Jineetkumar Gawad

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: March 5, 2025

The transformation of normal breast cells into cancerous is a complex process influenced by both genetic and microenvironmental factors. Recent studies highlight the significant role membrane potential (Vm) alterations in this transformation. Cancer typically exhibit depolarized resting (RMP) compared to cells, which correlates with increased cellular activity more aggressive cancer behavior. These RMP Vm changes are associated altered ion channel activity, calcium dynamics, mitochondrial dysfunction, modified gap junction communication, disrupted signaling pathways. Such fluctuations influence key processes progression, including cell proliferation, migration, invasion. Notably, subtypes display frequent pronounced fluctuations. Understanding electrical properties provides new insights their behavior offers therapeutic targets, such as channels regulation. This review synthesizes current research on how various factors modulate proposes an electrophysiological model based experimental clinical data from literature. findings may pave way for novel pharmacological targets clinicians, researchers, pharmacologists treating cancer.

Language: Английский

Review of electrophysiological models to study membrane potential changes in breast cancer cell transformation and tumor progression DOI Creative Commons
Chitaranjan Mahapatra,

A. Kishore,

Jineetkumar Gawad

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: March 5, 2025

The transformation of normal breast cells into cancerous is a complex process influenced by both genetic and microenvironmental factors. Recent studies highlight the significant role membrane potential (Vm) alterations in this transformation. Cancer typically exhibit depolarized resting (RMP) compared to cells, which correlates with increased cellular activity more aggressive cancer behavior. These RMP Vm changes are associated altered ion channel activity, calcium dynamics, mitochondrial dysfunction, modified gap junction communication, disrupted signaling pathways. Such fluctuations influence key processes progression, including cell proliferation, migration, invasion. Notably, subtypes display frequent pronounced fluctuations. Understanding electrical properties provides new insights their behavior offers therapeutic targets, such as channels regulation. This review synthesizes current research on how various factors modulate proposes an electrophysiological model based experimental clinical data from literature. findings may pave way for novel pharmacological targets clinicians, researchers, pharmacologists treating cancer.

Language: Английский

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