Therapeutic effectiveness of different schemes for the associated form of mycosis in dogs DOI Open Access
M. I. Chupryna

VETERINARY SCIENCE TECHNOLOGIES OF ANIMAL HUSBANDRY AND NATURE MANAGEMENT, Journal Year: 2024, Volume and Issue: 10, P. 152 - 158

Published: Oct. 26, 2024

Fungal infections are quite common among dogs, and the development of a generalized form disease causes severe secondary infections. Today in Ukraine, most dogs companions that constantly with owner, therefore, some cases, from sick animals malassezia alternariosis, spreads to owners, causing allergic conditions skin respiratory system. The aim work was develop an effective treatment scheme for canine mycosis associated form. For this, two therapy schemes have been developed, which involve complex use etiotropic, symptomatic pathogenetic drugs. object study were 38 confirmed diagnosis Alternaria Malassezia disseminated Animals clinical signs dermatitis came clinic examined by cytological cultural methods identify causative agent establish final diagnosis. Later, groups formed according principle analogues, each had its own scheme. second more successful: 1) using etiotropic agents Vetbio Dr.Pets shampoo chlorhexidine ketoconazole every three days, SkinGuard spray twice day; 2) Apoquel relieve symptoms itching during first week therapy; 3) anti-inflammatory bioregulatory drug Traumel; 4) balanced dietary nutrition Specific CDD-HY feed; 5) elimination mechanical irritants avoiding walking on dusty places grass maintaining hygiene thoroughly washing drying paws after going outside. Successful considered disappearance negative repeated examination. Itching did not return stopping Apoquel, complete recovery occurred 3 weeks.

Language: Английский

Application of Artificial Gastrointestinal Tract Models in Veterinary Medicine DOI Creative Commons
С. К. Шебеко,

Heorhii Yurievich Drobot,

Andrey Koshchaev

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(9), P. 1222 - 1222

Published: April 26, 2025

Artificial gastrointestinal tract models have become essential tools in veterinary medicine, providing alternatives to vivo studies, which are labor-intensive, costly, and under certain circumstances even ethically challenging. These vitro facilitate the study of digestion, enable disease host-pathogen interaction modeling, allow for investigation nutrient absorption, microbiota, pharmacokinetics. Considering One Health concept, application systems investigations animals can clearly reflect human health, thus, it is pointing relevance adaptation already existing development new meet needs animal farming practices. This review explores compares various types models, including static dynamic systems, their applications across different species. Specific technical methodological considerations discussed core animal-developed -tested artificial integration with common 'omics' techniques. Dynamic such as RUSITEC PolyFermS, more accurately simulate processes, peristalsis, enzymatic activity, microbial fermentation. The studies employing approaches been conducted understanding analysis comprehensive discussion results.

Language: Английский

Citations

0
Dietary Supplementation with Methylsulfonylmethane and Myo-Inosito Supports Hair Quality and Fecal Microbiome in Poodles DOI Creative Commons
Jie Zhang, Dan Guo, Limeng Zhang

et al.

Animals, Journal Year: 2024, Volume and Issue: 14(24), P. 3643 - 3643

Published: Dec. 17, 2024

This study aimed to investigate the effects of dietary supplementation with methylsulfonylmethane (MSM) and myo-inositol (MI) on hair quality, fecal microbiota, metabolome in poodles. Thirty-two adult poodles categorized based initial body weight sex were randomly assigned four groups. These groups (designated CON, MSM, MI, MSM + MI groups) received a basal diet, same diet supplemented 0.2% 0% or respectively. The lasted for 65 days. During entire period, weight, average daily gain, feed intake, energy output normal all animals did not differ significantly among treatment Hair scale thickness was lower than CON group Day (p < 0.05). An amino acid analysis revealed higher sulfur content 0 Moreover, presented levels Proteobacteria_unclassified Candidatus Phytoplasma those group. relative abundance Gammaproteobacteria_unclassified greater Glucerabacter Compared groups, abundances Paramuribaculum Hafnia Enterobacter Kineothrix 0.05) Bacteroidales_unclassified, Halanaerobium, Mycobacterium, Erysipelotrichaceae_unclassified Fecal metabolomics that markedly affected carbohydrate metabolism. also influenced lipid findings suggest can improve quality

Language: Английский

Citations

2
Stress and the domestic cat: have humans accidentally created an animal mimic of neurodegeneration? DOI Creative Commons
Ingrid R. Niesman

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: July 19, 2024

Many neurodegenerative diseases (NDD) appear to share commonality of origin, chronic ER stress. The endoplasmic reticulum (ER) is a dynamic organelle, functioning as major site protein synthesis and posttranslational modifications, required for proper folding. stress can occur because external stimuli, such oxidative or neuroinflammatory cytokines, creating the luminal environment permissive accumulation aggregated misfolded proteins. Unresolvable upregulates highly conserved pathway, unfolded response (UPR). Maladaptive activation UPR components leads apoptotic neuronal death. In addition other factors, physiological responses stressors are emerging significant risk factor in etiology pathogenesis NDD. Owned cats common with people, being exposed many same people additional pressures due their “quasi” domesticated status. Feline Cognitive Dysfunction Syndrome (fCDS) presents disease hallmarks human prevalence fCDS rapidly increasing more welcome companions. Barely recognized 20 years ago, veterinarians scientists infancy stages understanding what very complex disease. This review will describe how may represent an unexplored animal mimetic phenotype NDD potential triggering mechanisms. We consider multiple variations stressful events over short-life span cat could affect loss glial dysfunction ultimately tip balance towards dementia.

Language: Английский

Citations

0
Therapeutic effectiveness of different schemes for the associated form of mycosis in dogs DOI Open Access
M. I. Chupryna

VETERINARY SCIENCE TECHNOLOGIES OF ANIMAL HUSBANDRY AND NATURE MANAGEMENT, Journal Year: 2024, Volume and Issue: 10, P. 152 - 158

Published: Oct. 26, 2024

Fungal infections are quite common among dogs, and the development of a generalized form disease causes severe secondary infections. Today in Ukraine, most dogs companions that constantly with owner, therefore, some cases, from sick animals malassezia alternariosis, spreads to owners, causing allergic conditions skin respiratory system. The aim work was develop an effective treatment scheme for canine mycosis associated form. For this, two therapy schemes have been developed, which involve complex use etiotropic, symptomatic pathogenetic drugs. object study were 38 confirmed diagnosis Alternaria Malassezia disseminated Animals clinical signs dermatitis came clinic examined by cytological cultural methods identify causative agent establish final diagnosis. Later, groups formed according principle analogues, each had its own scheme. second more successful: 1) using etiotropic agents Vetbio Dr.Pets shampoo chlorhexidine ketoconazole every three days, SkinGuard spray twice day; 2) Apoquel relieve symptoms itching during first week therapy; 3) anti-inflammatory bioregulatory drug Traumel; 4) balanced dietary nutrition Specific CDD-HY feed; 5) elimination mechanical irritants avoiding walking on dusty places grass maintaining hygiene thoroughly washing drying paws after going outside. Successful considered disappearance negative repeated examination. Itching did not return stopping Apoquel, complete recovery occurred 3 weeks.

Language: Английский

Citations

0