systemic correlation between wound and diabetes DOI Open Access

Avijit Mazumdar,

Sanjana Sanjana,

Vikas Gupta

et al.

International Journal of Health Sciences, Journal Year: 2022, Volume and Issue: unknown, P. 8091 - 8115

Published: July 13, 2022

The current article provides complete information on the association between wounding and diabetes, as well a brief overview of Wound, Diabetic wounds treatment options. require special attention like major clinical societal challenge. need research is increased because delayed compromised healing. New techniques, Single growth factors, skin substitutes, interleukin stimulators, inhibitors, matrix metalloproteinase gene stem cell therapies, extracellular matrix, angiogenesis are only few examples. show that healing moving quickly. Despite fact multiple studies diabetes causes slowed wound healing, more precise mechanistic understanding into components involved, their parts still being played needed. This review focuses cytokine (with factors) other molecular cascades previously unknown cause pathways recent advancements in treatment. Clinicians academics working relevant fields were given briefing new innovative knowledge possible targets therapeutic including trials, this article.

Language: Английский

Opto-Laser-Responsive Smart NanoGel with Mild Hyperthermia, Vascularization, and Anti-Inflammatory Potential for Boosting Hard-to-Heal Wounds in a Diabetic Mice Model DOI

Bhakti Pawar,

Shivam Otavi,

Amrita Singh

et al.

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

It is well known that impaired wound healing associated with diabetes mellitus has led to a challenging problem as global economic healthcare burden. Conventional care therapies like films, gauze, and bandages fail cure diabetic wounds, thereby demanding synergistic promising therapy. This investigation aimed develop novel, greener synthesis of laser-responsive silver nanocolloid (LR-SNC) prepared using hyaluronic acid bioreductant. The LR-SNC was embedded into stimuli-responsive in situ gel (LR-SNC-in gel) for easy application the region. physicochemical characterization revealed nanometric hydrodynamic particle size 25.59 ± 0.72 nm an −31.8 0.7 mV surface ζ-potential. photothermal conversion efficiency observed up 62.9 0.1 °C. In vitro evaluation without NIR laser irradiation exhibited >70% cell viability, confirming its cytocompatibility human keratinocyte cells. scratch assay showed significant closure 75.50 0.02%. Further, addition cytocompatible followed by resulted substantial vivo (86.69 2.48%) wound-bearing mouse. Histological demonstrated salient features healed such increased neovascularization, collagen density, migration keratinocytes, growth hair follicles. Additionally, findings decrease levels pro-inflammatory cytokines (IL-6, IL-1β, TNF-α) enhanced angiogenesis gene expression (VEGF CD31), efficiently. present study confirmed potential role nanocolloids treating mouse models.

Language: Английский

Citations

0
A multi-targeted In Silico approach to select and rank regenerative drugs for managing diabetic wound inflammation signalling through IGFR, TNFR and PPAR -γ pathways DOI Creative Commons

Lakshmi Priyadarsini S,

L Sreelakshmi,

S. Adebisi S.

et al.

BIO Web of Conferences, Journal Year: 2025, Volume and Issue: 172, P. 02004 - 02004

Published: Jan. 1, 2025

The present research work explores the possibilities of molecular docking to predict and rank most suitable drugs for diabetic foot ulcer or any degenerate inflammatory wounds among ten different commonly used in wound regeneration. This is achieved by targeting multiple pathways simultaneously inflammation healing, Tumour necrosis factor Receptor pathway (TNFR) Peroxisome Proliferator-Activated -γ (PPAR-γ) macrophage polarization, management, collagen deposition etc., Insulin-like Growth Factor (IGFR) signalling Molecular studies were carried out using Swiss Dock which ranked natural Phyto estrogenic isoflavone Genistein as best having strong binding affinity all receptors TNFR, PPAR-γ, IGFR; highlighting its potential regulate inflammation, pro angiogenic properties thus

Language: Английский

Citations

0
Identification of antibiotic resistance profiles in diabetic foot infections: A machine learning proof-of-concept analysis DOI
Rodrigo M. Carrillo‐Larco,

Edmundo de Elvira Mori Orrillo,

Manuel Castillo-Cara

et al.

International Journal of Diabetes in Developing Countries, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Language: Английский

Citations

0
RESPONSIVE TO ADAPTIVE SUPRAMOLECULAR HYDROGELS FOR DIABETIC WOUND TREATMENT. DOI Creative Commons

Shalini Balakrishnan,

Revathy Remesh,

Kalathil K. Kartha

et al.

Supramolecular Materials, Journal Year: 2024, Volume and Issue: unknown, P. 100081 - 100081

Published: Nov. 1, 2024

Language: Английский

Citations

3
systemic correlation between wound and diabetes DOI Open Access

Avijit Mazumdar,

Sanjana Sanjana,

Vikas Gupta

et al.

International Journal of Health Sciences, Journal Year: 2022, Volume and Issue: unknown, P. 8091 - 8115

Published: July 13, 2022

The current article provides complete information on the association between wounding and diabetes, as well a brief overview of Wound, Diabetic wounds treatment options. require special attention like major clinical societal challenge. need research is increased because delayed compromised healing. New techniques, Single growth factors, skin substitutes, interleukin stimulators, inhibitors, matrix metalloproteinase gene stem cell therapies, extracellular matrix, angiogenesis are only few examples. show that healing moving quickly. Despite fact multiple studies diabetes causes slowed wound healing, more precise mechanistic understanding into components involved, their parts still being played needed. This review focuses cytokine (with factors) other molecular cascades previously unknown cause pathways recent advancements in treatment. Clinicians academics working relevant fields were given briefing new innovative knowledge possible targets therapeutic including trials, this article.

Language: Английский

Citations

0