Cathodal Transcranial Direct Current Stimulation Does Not Change Implicit Associations Against Alcohol in Alcohol Use Disorder: A Preregistered Clinical Trial DOI Creative Commons
Tobias Schwippel, Philipp A. Schroeder,

Janik Philipp

et al.

Addiction Biology, Journal Year: 2025, Volume and Issue: 30(3)

Published: March 1, 2025

ABSTRACT Addictive behaviour is shaped by the dynamic interaction of implicit, bottom‐up and explicit, top‐down cognitive processes. In alcohol use disorder (AUD), implicit alcohol‐related associations have been shown to predict increased subsequent consumption are linked risk relapse. Explicit processes, exerting prefrontal control, particularly significant during critical period following decision abstain. This study aims map explicit processes in recently abstinent individuals with AUD explore effect cathodal transcranial direct current stimulation (tDCS) on modulating control. this preregistered, double‐blind, sham‐controlled clinical trial, 30 participated two experimental sessions. They received either 2 mA tDCS left dorsolateral cortex (dlPFC) or sham a crossover design. During tDCS, participants completed approach association test (IAT) drinking identity IAT, along control tasks. Additionally, we collected ratings IAT stimuli assessed craving before after each session. Preregistered ANOVAs revealed alcohol–avoidance non–drinking biases. Cathodal did not modulate scores. showed preference for non‐alcoholic drinks non‐drinking identity, correlating moderately Exploratory analyses indicated that mitigated increase nicotine preregistered trial provides robust evidence single‐session does AUD, Bayesian corroborating absence effects. Our results emphasize impact contextual factors interplay between underscore importance investigating multisession paradigms future research.

Language: Английский

Cathodal Transcranial Direct Current Stimulation Does Not Change Implicit Associations Against Alcohol in Alcohol Use Disorder: A Preregistered Clinical Trial DOI Creative Commons
Tobias Schwippel, Philipp A. Schroeder,

Janik Philipp

et al.

Addiction Biology, Journal Year: 2025, Volume and Issue: 30(3)

Published: March 1, 2025

ABSTRACT Addictive behaviour is shaped by the dynamic interaction of implicit, bottom‐up and explicit, top‐down cognitive processes. In alcohol use disorder (AUD), implicit alcohol‐related associations have been shown to predict increased subsequent consumption are linked risk relapse. Explicit processes, exerting prefrontal control, particularly significant during critical period following decision abstain. This study aims map explicit processes in recently abstinent individuals with AUD explore effect cathodal transcranial direct current stimulation (tDCS) on modulating control. this preregistered, double‐blind, sham‐controlled clinical trial, 30 participated two experimental sessions. They received either 2 mA tDCS left dorsolateral cortex (dlPFC) or sham a crossover design. During tDCS, participants completed approach association test (IAT) drinking identity IAT, along control tasks. Additionally, we collected ratings IAT stimuli assessed craving before after each session. Preregistered ANOVAs revealed alcohol–avoidance non–drinking biases. Cathodal did not modulate scores. showed preference for non‐alcoholic drinks non‐drinking identity, correlating moderately Exploratory analyses indicated that mitigated increase nicotine preregistered trial provides robust evidence single‐session does AUD, Bayesian corroborating absence effects. Our results emphasize impact contextual factors interplay between underscore importance investigating multisession paradigms future research.

Language: Английский

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