Mechanism of PI3K/Akt‑mediated mitochondrial pathway in obesity‑induced apoptosis (Review) DOI Open Access
Jiarui Li,

Manyi Sun,

Ming Tang

et al.

Biomedical Reports, Journal Year: 2024, Volume and Issue: 22(3)

Published: Dec. 27, 2024

Obesity is a pervasive global health challenge that substantially reduces the quality of life millions individuals and impedes social economic advancement. an independent risk factor contributes to range chronic non‑communicable metabolic diseases, significantly affecting energy metabolism, mental health, cancer susceptibility, sleep quality, other physiological processes. The PI3K/AKT signaling pathway, significant glucose, lipid, protein metabolism regulator, integral cellular growth, survival, apoptosis. Apoptosis highly regulated form programmed cell death critical for immune maturation tissue repair. present review examines association between obesity, mitochondrial apoptosis elucidate potential mechanisms by which obesity may activate apoptotic pathways. These findings provide theoretical foundation mitigating obesity‑related complications targeting these

Language: Английский

Alzheimer’s, Parkinson’s, Frontotemporal Lobar Degeneration, and Amyotrophic Lateral Sclerosis Start in Pediatric Ages: Ultrafine Particulate Matter and Industrial Nanoparticles Are Key in the Early-Onset Neurodegeneration: Time to Invest in Preventive Medicine DOI Creative Commons
Lilian Calderón‐Garcidueñas, Angélica González-Maciel, Rafael Reynoso-Robles

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 178 - 178

Published: Feb. 28, 2025

Billions of people are exposed to fine particulate matter (PM2.5) levels above the USEPA’s annual standard 9 μg/m3. Common emission sources anthropogenic, producing complex aerosolized toxins. Ultrafine (UFPM) and industrial nanoparticles (NPs) have major detrimental effects on brain, but USA does not measure UFPM a routine basis. This review focuses development progression common neurodegenerative diseases, as diagnosed through neuropathology, among young residents in Metropolitan Mexico City (MMC). MMC is one most polluted megacities world, with population 22 million residents, many whom unaware brain caused by their atmosphere. Fatal diseases (such Alzheimer’s Parkinson’s) that begin childhood populations living air environments preventable. We conclude UFPM/NPs capable disrupting neural homeostasis give rise relentless processes throughout entire life highly MMC. The paradigm reaching old age neurodegeneration no longer supported. Neurodegenerative changes start early pediatric ages irreversible. It time invest preventive medicine.

Language: Английский

Citations

0
Pharmacological landscape of endoplasmic reticulum stress: uncovering therapeutic avenues for metabolic diseases DOI
Ghallab Alotaibi,

Abdullah Alkhammash

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177509 - 177509

Published: March 1, 2025

Language: Английский

Citations

0
Obesity: pathophysiology and therapeutic interventions DOI Creative Commons
Yue Kong, Hong Seuk Yang, Rong Nie

et al.

Molecular Biomedicine, Journal Year: 2025, Volume and Issue: 6(1)

Published: April 25, 2025

Abstract Over the past few decades, obesity has transitioned from a localized health concern to pressing global public crisis affecting over 650 million adults globally, as documented by WHO epidemiological surveys. As chronic metabolic disorder characterized pathological adipose tissue expansion, inflammation, and neuroendocrine dysregulation that disrupts systemic homeostasis impairs physiological functions, is rarely an isolated condition; rather, it frequently complicated severe comorbidities collectively elevate mortality risks. Despite advances in nutritional science initiatives, sustained weight management success rates prevention remain limited, underscoring its recognition multifactorial disease influenced genetic, environmental, behavioral determinants. Notably, escalating prevalence of earlier onset younger populations have intensified urgency develop novel therapeutic agents simultaneously ensure efficacy safety. This review aims elucidate pathophysiological mechanisms underlying obesity, analyze major complications—including type 2 diabetes mellitus (T2DM), cardiovascular diseases (CVD), non-alcoholic fatty liver (NAFLD), obesity-related respiratory disorders, nephropathy (ORN), musculoskeletal impairments, malignancies, psychological comorbidities—and critically evaluate current anti-obesity strategies. Particular emphasis placed on emerging pharmacological interventions, exemplified plant-derived natural compounds such berberine (BBR), with focus their molecular mechanisms, clinical efficacy, advantages. By integrating mechanistic insights evidence, this seeks provide innovative perspectives for developing safe, accessible, effective treatments.

Language: Английский

Citations

0
Mechanism of PI3K/Akt‑mediated mitochondrial pathway in obesity‑induced apoptosis (Review) DOI Open Access
Jiarui Li,

Manyi Sun,

Ming Tang

et al.

Biomedical Reports, Journal Year: 2024, Volume and Issue: 22(3)

Published: Dec. 27, 2024

Obesity is a pervasive global health challenge that substantially reduces the quality of life millions individuals and impedes social economic advancement. an independent risk factor contributes to range chronic non‑communicable metabolic diseases, significantly affecting energy metabolism, mental health, cancer susceptibility, sleep quality, other physiological processes. The PI3K/AKT signaling pathway, significant glucose, lipid, protein metabolism regulator, integral cellular growth, survival, apoptosis. Apoptosis highly regulated form programmed cell death critical for immune maturation tissue repair. present review examines association between obesity, mitochondrial apoptosis elucidate potential mechanisms by which obesity may activate apoptotic pathways. These findings provide theoretical foundation mitigating obesity‑related complications targeting these

Language: Английский

Citations

0