Treating Metabolic Dysregulation and Senescence by Caloric Restriction: Killing Two Birds with One Stone?

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 99 - 99

Published: Jan. 16, 2025

Cellular senescence is a state of permanent cell cycle arrest accompanied by metabolic activity and characteristic phenotypic changes. This process crucial for developing age-related diseases, where excessive calorie intake accelerates dysfunction aging. Overnutrition disturbs key pathways, including insulin/insulin-like growth factor signaling (IIS), the mammalian target rapamycin (mTOR), AMP-activated protein kinase. The dysregulation these pathways contributes to insulin resistance, impaired autophagy, exacerbated oxidative stress, mitochondrial dysfunction, further enhancing cellular systemic derangements. On other hand, dysfunctional endothelial cells adipocytes contribute inflammation, reduced nitric oxide production, altered lipid metabolism. Numerous factors, extracellular vesicles, mediate pathological communication between vascular system adipose tissue, amplifying imbalances. Meanwhile, caloric restriction (CR) emerges as potent intervention counteract overnutrition effects, improve function, reduce restore balance. CR modulates such IIS, mTOR, sirtuins, glucose metabolism, reducing promoting autophagy. can extend health span mitigate diseases delaying improving healthy endothelial-adipocyte interactions. review highlights crosstalk adipocytes, emphasizing potential in counteracting overnutrition-induced restoring homeostasis.

Language: Английский

Comorbidity results of an obesity center

The European Research Journal, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: Feb. 19, 2025

Objectives: Obesity is linked to numerous severe health conditions, including type 2 diabetes mellitus, heart disease, hypertension, and stroke. This study aimed compare metabolic parameters anthropometric measurements between male female patients with obesity identify gender-based differences in obesity-related markers. Methods: prospective enrolled 393 obese (52 male, 341 female) from an outpatient clinic. After overnight fast (8-10 hours), blood samples were collected assess a range of parameters: complete count, fasting glucose, insulin, Hemoglobin A1c (HbA1c), Aspartate aminotransferase (AST), Alanine (ALT), Thyroid-stimulating hormone (TSH), total cholesterol, triglycerides, Low-density lipoprotein (LDL), High-density (HDL), 25-hydroxy vitamin D3 (25OHD3), ferritin, iron, B12. Homeostatic Model Assessment Insulin Resistance (HOMA-IR) Body Mass Index (BMI) calculated, while soft lean mass (SLM) percent body fat (PBF) also analyzed. Results: Males had significantly higher levels HOMA-IR, 25OHD3, hemoglobin, hematocrit, urea, ALT compared females (P<0.05 for all). Conversely, males lower HDL platelet (P<0.05). The prevalence thyroid disease was (P=0.027). Conclusions: Thyroid males. Additionally, such as urea elevated females,

Language: Английский