Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11
Published: Dec. 9, 2024
Heart failure is a complex syndrome characterized by impaired cardiac function. Despite improvements in treatment, the prevalence of heart continues to rise. The Cardiometabolic Index (CMI), novel measure combining abdominal obesity and lipid levels, has emerged as potential predictor metabolic risk.
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 577 - 577
Published: Jan. 11, 2025
Melatonin is involved in various functions such as the timing of circadian rhythms, energy metabolism, and body mass gain experimental animals. However, its effects on adipose tissue lipid metabolism are still unclear. This study analyzes melatonin relative gene expression lipolytic proteins rat mesenteric free fatty acid (FFA) glycerol plasma levels male Wistar rats fed a high-fat (HFD) or maintenance diet. Four groups were established: control, obese, control obese plus 2.3 mg/kg/day tap water. After 11 weeks, animals sacrificed at different times throughout 24 h cycle, samples collected analyzed. Cgi58, Perilipin, Dgat1 expression, well FFA concentrations, showed rhythm patterns group. HFD disrupted those increased concentrations during dark photoperiod. In both melatonin-treated groups, almost all analyzed genes patterns. Notably, significantly prevented increase photoperiod (obese group: ~1100 mM vs. + ~600 μM, similar to levels). rhythmic pattern observed was not sustained. According our results, could regulate transcription lipolysis proteins. The effect preventing elevated associated with diet intake warrants further investigation.
Language: Английский
Citations
0
Indian Journal of Clinical Biochemistry, Journal Year: 2025, Volume and Issue: unknown
Published: April 11, 2025
Language: Английский
Citations
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Molecules, Journal Year: 2025, Volume and Issue: 30(9), P. 1888 - 1888
Published: April 23, 2025
Circadian rhythms are molecular oscillations governed by transcriptional–translational feedback loops (TTFLs) operating in nearly all cell types and fundamental to physiological homeostasis. Key circadian regulators, such as locomotor output cycles kaput (CLOCK), brain muscle ARNT-like 1 (BMAL1), period (PER), cryptochrome (CRY) gene families, regulate intracellular metabolism, oxidative balance, mitochondrial function, synaptic plasticity. disruption is known a central contributor the pathophysiology of neurodegenerative disorders. Disease-specific disruptions clock expression melatoninergic signaling potential early-stage biomarkers. Melatonin, neurohormone secreted pineal gland, modulates expression, stability, inflammatory responses. It also regulates epigenetic metabolic processes through nuclear receptors regulators involved cellular stress pathways, thereby exerting neuroprotective effects maintaining neuronal integrity. This review provides recent findings from past five years, highlighting how dysregulation mediates key disturbances translational circadian-based therapies diseases.
Language: Английский
Citations
0
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 28, 2024
Background: Shift work is essential in health care because of the need for 24-hour services but it associated with adverse outcomes, including disrupted circadian rhythms, poor sleep, unhealthy dietary habits, and increased stress. These effects may differ across job categories, such as nursing officers hospital support staff, owing to varying physical psychological demands. Limited research exists on how shift impacts these groups differently, particularly regarding readiness change lifestyle behaviors. Objectives: This study aims assess compare factors six domains - nutrition, activity, stress, social relationships, addictions between staff rotating shifts versus fixed daytime duties. It also evaluate association patterns type determine influence category parameters after adjusting confounders demographics body composition. Methodology: A case-control was conducted at All India Institute Medical Sciences (AIIMS) Nagpur from December 2023 June 2024. The involved 327 participants (165 cases 162 controls) comprising nurses aged 21-45 years. case group included 83 84 working least three years, while control consisted 81 members schedules. General assessments, demographics, composition (InBody 770), assessments sleep (Pittsburgh Sleep Quality Index; PSQI), stress (Perceived Stress Scale; PSS-10), connectivity (Social Support Questionnaire), alcohol use (a modified version 10-item Alcohol Use Disorders Identification Test (AUDIT-C)) were performed. Readiness behaviors assessed using stages model. Results: workers had a significantly higher weight (p = 0.030), larger waist circumference 0.029), calorie intake 0.043) than non-shift workers. They exhibited lower cardiovascular fitness 0.021) reduced water 0.043). Among officers, poorer quality 0.003) 0.046). levels paradoxically among 0.025) not staff. did all domains. Logistic regression showed that (odds ratio (OR): 6.503, p 0.038), no significant associations found other parameters. Conclusion: highlights composition, intake, fitness, workers, officers. Despite risks, similar suggesting directly motivation changes. findings underscore tailored interventions targeting specific challenges improve their overall well-being productivity.
Language: Английский
Citations
0
Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11
Published: Dec. 9, 2024
Heart failure is a complex syndrome characterized by impaired cardiac function. Despite improvements in treatment, the prevalence of heart continues to rise. The Cardiometabolic Index (CMI), novel measure combining abdominal obesity and lipid levels, has emerged as potential predictor metabolic risk.
Language: Английский
Citations
0