Epigenetic Landscapes of Aging in Breast Cancer Survivors: Unraveling the Impact of Therapeutic Interventions—A Scoping Review

Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 866 - 866

Published: March 3, 2025

Breast cancer therapies have dramatically improved survival rates, but their long-term effects, especially on aging survivors, need careful consideration. This review delves into how breast treatments and intersect, focusing the epigenetic changes triggered by chemotherapy, radiation, hormonal treatments, targeted therapies. Treatments can speed up biological altering DNA methylation, histone modifications, chromatin remodeling, affecting gene expression without changing sequence itself. The explains double-edged sword effect of therapy-induced which help fight also accelerate aging. Chemotherapy therapies, in particular, impact methylation promoting chronic inflammation shortening telomeres. These increase age, as seen clocks biomarkers like p21, play roles drug resistance therapeutic decisions. Chronic inflammation, driven higher levels inflammatory cytokines such TNF-α IL-6 well telomere shortening, significantly contributes to characteristics survivors. Non-coding RNAs, including microRNAs long non-coding are crucial regulating pathways altered these treatments. explores new targeting changes, inhibitors, deacetylase microRNA-based reduce effects therapy. Non-drug approaches, dietary lifestyle show promise combating It highlights clinical signs aging-related side heart lung problems, endocrine reproductive issues, reduced quality life. development comprehensive methods CHEMO-RADIAT score predict major cardiovascular events after therapy is discussed. Understanding caused offers valuable insights for creating interventions enhance health span life Continued research fully understand alterations impacts.

Language: Английский

---

Obesity, overweight and breast cancer: new clinical data and implications for practice

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 27, 2025

Excess bodyweight has negative consequences in breast cancer (BC) patients, significantly increasing the incidence of BC and adversely affecting clinical outcomes most subtypes. This article overviews recent evidence relating to excess (particularly obesity) its effect on treatment women with BC, focusing latest evidence, including findings from recently introduced new therapeutic entities. There is an inverse relationship between obesity premenopausal highlighting a complex interplay involving tumor microenvironment cells, patient factors such as hormonal/metabolic/inflammatory status. Advancements targeted- immune-therapy have brought renewed optimism for BC. Ultimately, better understanding mechanistic link adipogenicity tumorigenicity tissues, well how adipose tissue inflammation interact female sex hormones, may prove be important area further refinements our quest develop truly personalized approach this setting.

Language: Английский

---

Regulatory Roles of miR-155-5p, miR-21-5p, miR-93-5p, and miR-140-5p in Breast Cancer Progression

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(5), P. 377 - 377

Published: May 20, 2025

Breast cancer (BC) remains the leading cause of cancer-related morbidity and mortality worldwide, necessitating innovative approaches to improve diagnosis, prognosis, treatment. This case-control study, aimed evaluate expression profiles specific microRNAs (miRNAs)—miR-155-5p, miR-21-5p, miR-93-5p, miR-140-5p—in 50 female BC patients treated with paclitaxel (PTX) compared healthy controls. miRNA was analyzed using qPCR. The study revealed significant up regulation these miRNAs in patients, miR-155-5p miR-21-5p demonstrating highest diagnostic accuracy (AUC = 0.890 0.863, respectively). These are implicated key oncogenic processes, including tumor growth, angiogenesis, metastasis, chemoresistance, highlighting their potential as non-invasive biomarkers for diagnosis prognosis. Additionally, identified differences demographic biochemical parameters between controls, such lower hemoglobin RBC counts indicative anemia, elevated AST levels. findings underscore importance biology guide personalized therapeutic strategies. Validation larger cohorts is recommending exploring miRNA-based interventions patient outcomes overcome chemoresistance BC.

Language: Английский

---

Obesity and Risk of Pre- and Postmenopausal Breast Cancer in Africa: A Systematic Review

Current Oncology, Journal Year: 2025, Volume and Issue: 32(3), P. 167 - 167

Published: March 14, 2025

Background and Aims: Several epidemiological studies have investigated the relationship between anthropometric factors breast cancer (BC), but results, particularly for premenopausal BC, remain inconsistent contradictory. The aim of this systematic review is to present an overview examining association obesity BC risk in African women, by menopausal status. Methods: PubMed, Scopus, Web Science, Google Scholar were searched until 17 February 2025 identify published articles. included original studies, with no restrictions on publication date or language. exposures studied height, weight, body mass index (BMI), waist circumference (WC), hip (HC), waist-to-hip ratio (WHR). quality was assessed using National Institute Health (NIH). Study selection data extraction carried out two authors separately. Results: A total fifteen case–control review, comprising 45,056 subjects (7221 cases 37,835 controls). Among them, fourteen reported stratified results pre- postmenopausal one findings only BC. We found that BMI associated increased both though associations varied across studies. Height WHR positively while WC showed a positive Finally, higher HC Conclusions: developing obese women. protective role has not been demonstrated factor There need study influence stages overweight large sample women in-depth.

Language: Английский

---

Weight-adjusted-waist index: an innovative indicator of breast cancer hazard

BMC Women s Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 21, 2024

Central obesity and breast cancer (BC) have been identified as relevant by empirical research. The weight-adjusted-waist index (WWI) is a novel methodology for quantifying central obesity. Inspection of the association between WWI BC in American adult women was primary goal current investigation. Cross-sectional assessments were conducted on information gathered from 10,193 National Health Nutrition Examination Survey (NHANES) participants 2011 to 2018. waist circumference divided square root body's mass compute WWI. Data assessed via descriptive statistics present data distributions according grouping grouping, receiver operating characteristic curves (ROCs) evaluate indicators' applied value, logistic regression reflect associations prevalence, restricted cubic splines (RCSs) subgroup analysis forest plots visualise complement relationships. This study enrolled whose ranged 8.38 14.41, 259 whom diagnosed with BC, results revealed significant differences baseline characteristics groups. With an area under curve (AUC) value (95% confidence interval) (CI)of 0.611 (0.577–0.644), promising indicator good application rather than (WC), body (BMI), or waist-height ratio (WHtR). laid out substantial relationship, yielding odds (OR) 1.54 95% CI (1.34, 1.79), which remained at 1.19 (1.00, 1.42) after considerable adjustments made, analysis. Compared lowest quartile WWI, highest had 62% greater probability suffering BC. RCS's inverted U-shape highlighting importance considering nonlinear nature relationship analyses reflecting variations among populations, all demonstrated that well-suggestive hazard. investigation meaningful prevalence superior other indicators, albeit one more complex positive initially derived. There existed turning point approximately 12 cm/√kg. Nevertheless, maintaining lower range critical preventing administering minimizing disease risk.

Language: Английский

---