The protective effect of astaxanthin on fetal alcohol spectrum disorder in mice

Neuropharmacology, Journal Year: 2014, Volume and Issue: 84, P. 13 - 18

Published: April 26, 2014

Language: Английский

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Effects of maternal drinking patterns and epigallocatechin-3-gallate treatment on behavioural and molecular outcomes in a mouse model of fetal alcohol spectrum disorders

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 187, P. 118138 - 118138

Published: May 10, 2025

Language: Английский

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Validity of the T-ACE in pregnancy in predicting child outcome and risk drinking

Alcohol, Journal Year: 2010, Volume and Issue: 44(7-8), P. 595 - 603

Published: Jan. 7, 2010

Language: Английский

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Effects of ethanol and ipsapirone on the expression of genes encoding anti-apoptotic proteins and an antioxidant enzyme in ethanol-treated neurons

Brain Research, Journal Year: 2008, Volume and Issue: 1249, P. 54 - 60

Published: Nov. 26, 2008

Language: Английский

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Development and validation of an infant morbidity index using latent variable models

Statistics in Medicine, Journal Year: 2007, Volume and Issue: 27(7), P. 971 - 989

Published: June 15, 2007

Abstract Birth defect, abnormal condition of the newborn, developmental delay or disability and low birth weight are four major infant morbidity outcomes. Most studies have focused on assessment effects risk factors each these outcomes relationship among both. Little attention has been paid to development a composite index, which is summary construct In this paper, we develop extended latent variable (LV) models modified Gauss–Newton algorithms for multiple multinomial with complete responses. By assuming marginal distribution LV be log‐normal, model conditional probability outcome as nonlinear function LV, properties similar logistic function. The estimated generalized least‐square method used solve equations parameters interest. applied an data set. A new single variable, called index (IMI) that functions represents propensity morbidity, developed. validity then assessed in detail. It shown IMI correlated individual outcomes, mortality face‐valid can future research measure morbidity. Copyright © 2007 John Wiley & Sons, Ltd.

Language: Английский

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A exposição ao enriquecimento ambiental durante a gestação reduz os prejuízos causados pelo etanol no comportamento materno e no desenvolvimento da prole em camundongos.

Published: March 10, 2023

O consumo de álcool durante a gestação constitui um grave problema saúde pública, uma vez que ele ultrapassa barreira placentária e afeta o desenvolvimento embrio-fetal.Além dos efeitos diretos da exposição ao no feto, também pode interferir cuidado mãe expressa com filhote, já droga parece interromper interação entre eles, reduzir liberação materna ocitocina (OT).Já enriquecimento ambiental (EA) aumentar os comportamentos direcionados aos filhotes tem se mostrado capaz modular sistema ocitocinérgico.O objetivo do estudo foi avaliar EA (24h ou 3h por dia), gestação, sobre comportamento materno, prole.Para isso, camundongos Swiss fêmeas foram divididas em quatro grupos: alojadas gaiolapadrão tratadas água (CT-NE); gaiola-padrão etanol (3 g/kg; EtOH-NE); (CT-EA); (EtOH-EA).As introduzidas tratamento realizado gavagem dia (GD) 15 pós-natal (PND) 10. materno avaliado PND3

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Influencia de fatores ambientais e geneticos relacionados com a agenesia dental e microdontia

Published: Dec. 13, 2007

The term hypodontia can be defined as a congenital absence of one or more teeth and microdontia with alterations dimensional.The most affected are the third molars, seconds premolars lateral incisors.Genetic environmental factors such PAX9 MSX1 genes malnutrition alcohol directly affect odontogenesis.The objective this study was to analyze influence gene regions chronic intake during pregnancy in odontogenesis, through analysis genetic polymorphism morphology rats molars.In first analyzed genomic DNA 130 individuals agenesis 110 controls.After obtaining extraction DNA, region.After extraction, region G/C-915 (NCBI ref SNP ID: rs 2073247) amplyfied by polymerase chain reaction (PCR).The polymorphic sites were two different primers sequences.The gel bands stained silver nitrate.Data Monte Carlo simulations (Clump software) Chi-squared test (x 2)with significance level 5%.The showed that promoter had high frequency molars hypodontia.In second studied and, though, there no relationship introns agenesis, C-160T (www.ncbi.nlm.nih.gov/ between agenesis.About factors, thesis assessing effects administered lactation lowers rats.There reduction size Knoop microhardness these dental elements.

Language: Английский

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Manifestações oculares do transtorno do espectro alcoólico fetal: revisão bibliográfica / Ocular manifestations of fetal alcohol spectrum disorders: a bibliographic review

Arquivos Médicos dos Hospitais e da Faculdade de Ciências Médicas da Santa Casa de São Paulo, Journal Year: 2020, Volume and Issue: 65(1), P. 1 - 1

Published: July 2, 2020

Introdução: O consumo de álcool por gestantes é reconhecidamente teratogênico, levando aos Transtornos do Espectro Alcoólico Fetal (TEAF). Indivíduos com esse espectro apresentam alterações em características faciais nariz, lábios e orelhas, além das oculares. Objetivo: Realizar um levantamento literatura científica para verificar as manifestações oculares presentes pacientes diagnosticados TEAF. Método: Foram pesquisados nos bancos dados: Pubmed, Scielo, Cochrane Lilacs artigos que trouxessem o tema descrito acima. Os dados obtidos da consulta foram tabulados os seguintes parâmetros: estudo/ano, tipo estudo/nível evidencia, amostra resultados. Resultados Conclusão: De total 71 trabalhos, após análises acordo critérios inclusão exclusão, selecionados 8. As principais relacionadas à TEAF foram, ordem decrescente: hipoplasia nervo óptico, ambliopia, estrabismo, configuração anormal dos vasos retinianos, deficiência função oculomotora, tamanho reduzido órbita ocular, anormalidade na percepção profundidade, displasia septo-óptica, astigmatismo anisometropia. No tocante às externas, foram: blefarofimose, epicanto telecanto.Palavras chave: alcoólico fetal, Oftalmopatias, Revisão ABSTRACTIntroduction: Alcohol consumption by pregnant women is knowned to be teratogenic, leading Spectrum Disorders (FASD). Individuals with this spectrum show changes in facial features of the nose, lips and ears, addition ocular ones. Objective: Perform a survey scientific literature verify manifestations present patients diagnosed FASD. Method: databases were searched for articles that presented theme described above. The data obtained from consultation tabulated following parameters: study / year, type study/evidence level, sample results. Results Conclusion: From studies, after analysis according inclusion exclusion criteria, 8 selected. main related FASD were, decreasing order: optic nerve hypoplasia, amblyopia, strabismus, configuration abnormal retinal vessels, impaired oculomotor function, reduced size eye socket, depth perception, septo-optic dysplasia, astigmatism With regard external manifestations, ones were: blepharophimosis, epicanthus telecanto.Key words: alcohol disorders, Eye diseases, Review

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