The protective effect of astaxanthin on fetal alcohol spectrum disorder in mice
Zheng Dong,
No information about this author
Yi Li,
No information about this author
Lei He
No information about this author
et al.
Neuropharmacology,
Journal Year:
2014,
Volume and Issue:
84, P. 13 - 18
Published: April 26, 2014
Language: Английский
Effects of maternal drinking patterns and epigallocatechin-3-gallate treatment on behavioural and molecular outcomes in a mouse model of fetal alcohol spectrum disorders
Melina Vieiros,
No information about this author
Laura Almeida-Toledano,
No information about this author
Mariona Serra-Delgado
No information about this author
et al.
Biomedicine & Pharmacotherapy,
Journal Year:
2025,
Volume and Issue:
187, P. 118138 - 118138
Published: May 10, 2025
Language: Английский
Validity of the T-ACE in pregnancy in predicting child outcome and risk drinking
Lisa M. Chiodo,
No information about this author
Robert J. Sokol,
No information about this author
Virginia Delaney‐Black
No information about this author
et al.
Alcohol,
Journal Year:
2010,
Volume and Issue:
44(7-8), P. 595 - 603
Published: Jan. 7, 2010
Language: Английский
Effects of ethanol and ipsapirone on the expression of genes encoding anti-apoptotic proteins and an antioxidant enzyme in ethanol-treated neurons
Jong-Ho Lee,
No information about this author
Nuzhath F. Tajuddin,
No information about this author
Mary J. Druse
No information about this author
et al.
Brain Research,
Journal Year:
2008,
Volume and Issue:
1249, P. 54 - 60
Published: Nov. 26, 2008
Language: Английский
Development and validation of an infant morbidity index using latent variable models
Statistics in Medicine,
Journal Year:
2007,
Volume and Issue:
27(7), P. 971 - 989
Published: June 15, 2007
Abstract
Birth
defect,
abnormal
condition
of
the
newborn,
developmental
delay
or
disability
and
low
birth
weight
are
four
major
infant
morbidity
outcomes.
Most
studies
have
focused
on
assessment
effects
risk
factors
each
these
outcomes
relationship
among
both.
Little
attention
has
been
paid
to
development
a
composite
index,
which
is
summary
construct
In
this
paper,
we
develop
extended
latent
variable
(LV)
models
modified
Gauss–Newton
algorithms
for
multiple
multinomial
with
complete
responses.
By
assuming
marginal
distribution
LV
be
log‐normal,
model
conditional
probability
outcome
as
nonlinear
function
LV,
properties
similar
logistic
function.
The
estimated
generalized
least‐square
method
used
solve
equations
parameters
interest.
applied
an
data
set.
A
new
single
variable,
called
index
(IMI)
that
functions
represents
propensity
morbidity,
developed.
validity
then
assessed
in
detail.
It
shown
IMI
correlated
individual
outcomes,
mortality
face‐valid
can
future
research
measure
morbidity.
Copyright
©
2007
John
Wiley
&
Sons,
Ltd.
Language: Английский
A exposição ao enriquecimento ambiental durante a gestação reduz os prejuízos causados pelo etanol no comportamento materno e no desenvolvimento da prole em camundongos.
Published: March 10, 2023
O
consumo
de
álcool
durante
a
gestação
constitui
um
grave
problema
saúde
pública,
uma
vez
que
ele
ultrapassa
barreira
placentária
e
afeta
o
desenvolvimento
embrio-fetal.Além
dos
efeitos
diretos
da
exposição
ao
no
feto,
também
pode
interferir
cuidado
mãe
expressa
com
filhote,
já
droga
parece
interromper
interação
entre
eles,
reduzir
liberação
materna
ocitocina
(OT).Já
enriquecimento
ambiental
(EA)
aumentar
os
comportamentos
direcionados
aos
filhotes
tem
se
mostrado
capaz
modular
sistema
ocitocinérgico.O
objetivo
do
estudo
foi
avaliar
EA
(24h
ou
3h
por
dia),
gestação,
sobre
comportamento
materno,
prole.Para
isso,
camundongos
Swiss
fêmeas
foram
divididas
em
quatro
grupos:
alojadas
gaiolapadrão
tratadas
água
(CT-NE);
gaiola-padrão
etanol
(3
g/kg;
EtOH-NE);
(CT-EA);
(EtOH-EA).As
introduzidas
tratamento
realizado
gavagem
dia
(GD)
15
pós-natal
(PND)
10.
materno
avaliado
PND3
Influencia de fatores ambientais e geneticos relacionados com a agenesia dental e microdontia
Published: Dec. 13, 2007
The
term
hypodontia
can
be
defined
as
a
congenital
absence
of
one
or
more
teeth
and
microdontia
with
alterations
dimensional.The
most
affected
are
the
third
molars,
seconds
premolars
lateral
incisors.Genetic
environmental
factors
such
PAX9
MSX1
genes
malnutrition
alcohol
directly
affect
odontogenesis.The
objective
this
study
was
to
analyze
influence
gene
regions
chronic
intake
during
pregnancy
in
odontogenesis,
through
analysis
genetic
polymorphism
morphology
rats
molars.In
first
analyzed
genomic
DNA
130
individuals
agenesis
110
controls.After
obtaining
extraction
DNA,
region.After
extraction,
region
G/C-915
(NCBI
ref
SNP
ID:
rs
2073247)
amplyfied
by
polymerase
chain
reaction
(PCR).The
polymorphic
sites
were
two
different
primers
sequences.The
gel
bands
stained
silver
nitrate.Data
Monte
Carlo
simulations
(Clump
software)
Chi-squared
test
(x
2)with
significance
level
5%.The
showed
that
promoter
had
high
frequency
molars
hypodontia.In
second
studied
and,
though,
there
no
relationship
introns
agenesis,
C-160T
(www.ncbi.nlm.nih.gov/
between
agenesis.About
factors,
thesis
assessing
effects
administered
lactation
lowers
rats.There
reduction
size
Knoop
microhardness
these
dental
elements.
Language: Английский
Manifestações oculares do transtorno do espectro alcoólico fetal: revisão bibliográfica / Ocular manifestations of fetal alcohol spectrum disorders: a bibliographic review
Arquivos Médicos dos Hospitais e da Faculdade de Ciências Médicas da Santa Casa de São Paulo,
Journal Year:
2020,
Volume and Issue:
65(1), P. 1 - 1
Published: July 2, 2020
Introdução:
O
consumo
de
álcool
por
gestantes
é
reconhecidamente
teratogênico,
levando
aos
Transtornos
do
Espectro
Alcoólico
Fetal
(TEAF).
Indivíduos
com
esse
espectro
apresentam
alterações
em
características
faciais
nariz,
lábios
e
orelhas,
além
das
oculares.
Objetivo:
Realizar
um
levantamento
literatura
científica
para
verificar
as
manifestações
oculares
presentes
pacientes
diagnosticados
TEAF.
Método:
Foram
pesquisados
nos
bancos
dados:
Pubmed,
Scielo,
Cochrane
Lilacs
artigos
que
trouxessem
o
tema
descrito
acima.
Os
dados
obtidos
da
consulta
foram
tabulados
os
seguintes
parâmetros:
estudo/ano,
tipo
estudo/nível
evidencia,
amostra
resultados.
Resultados
Conclusão:
De
total
71
trabalhos,
após
análises
acordo
critérios
inclusão
exclusão,
selecionados
8.
As
principais
relacionadas
à
TEAF
foram,
ordem
decrescente:
hipoplasia
nervo
óptico,
ambliopia,
estrabismo,
configuração
anormal
dos
vasos
retinianos,
deficiência
função
oculomotora,
tamanho
reduzido
órbita
ocular,
anormalidade
na
percepção
profundidade,
displasia
septo-óptica,
astigmatismo
anisometropia.
No
tocante
às
externas,
foram:
blefarofimose,
epicanto
telecanto.Palavras
chave:
alcoólico
fetal,
Oftalmopatias,
Revisão
ABSTRACTIntroduction:
Alcohol
consumption
by
pregnant
women
is
knowned
to
be
teratogenic,
leading
Spectrum
Disorders
(FASD).
Individuals
with
this
spectrum
show
changes
in
facial
features
of
the
nose,
lips
and
ears,
addition
ocular
ones.
Objective:
Perform
a
survey
scientific
literature
verify
manifestations
present
patients
diagnosed
FASD.
Method:
databases
were
searched
for
articles
that
presented
theme
described
above.
The
data
obtained
from
consultation
tabulated
following
parameters:
study
/
year,
type
study/evidence
level,
sample
results.
Results
Conclusion:
From
studies,
after
analysis
according
inclusion
exclusion
criteria,
8
selected.
main
related
FASD
were,
decreasing
order:
optic
nerve
hypoplasia,
amblyopia,
strabismus,
configuration
abnormal
retinal
vessels,
impaired
oculomotor
function,
reduced
size
eye
socket,
depth
perception,
septo-optic
dysplasia,
astigmatism
With
regard
external
manifestations,
ones
were:
blepharophimosis,
epicanthus
telecanto.Key
words:
alcohol
disorders,
Eye
diseases,
Review