Redox Role of ROS and Inflammation in Pulmonary Diseases

Advances in experimental medicine and biology, Journal Year: 2021, Volume and Issue: unknown, P. 187 - 204

Published: Jan. 1, 2021

Language: Английский

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<p>4-Octyl Itaconate Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting Oxidative Stress and Inflammation</p>

Drug Design Development and Therapy, Journal Year: 2020, Volume and Issue: Volume 14, P. 5547 - 5558

Published: Dec. 1, 2020

Acute lung injury (ALI) is a fatal disease in the absence of pharmacological treatment. Oxidative stress and inflammation are closely related to ALI. Innate immune cells main source reactive oxygen species (ROS). Macrophages play an extremely important role ALI through activation oxidative stress. Itaconate, metabolite tricarboxylic acid, has been reported have strong antioxidant anti-inflammatory effects. However, itaconate unclear. Herein, we use 4-octyl (OI), cellular permeable derivate itaconate, study effects vivo vitro.We used OI pretreat C57BL/6 mice LPS-induced models illustrate acute injury. The were randomly divided into four groups: control group, (100 mg/kg) Group, + (50 group. RAW264.7 further prove mechanism vitro.According H&E staining lung, was observed significantly reduce inflammation. active content tissues also reduced (P<0.05). accumulation neutrophils secretion inflammatory factors At level, Intervention with upregulate expression nuclear factor erythroid 2-related factor-2 (Nrf-2) Nrf-2 target genes tissue cells.OI alleviates Moreover, might depend on Nrf-2. Therefore, therapeutic potential for treatment

Language: Английский

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Luteolin activates Tregs to promote IL-10 expression and alleviating caspase-11-dependent pyroptosis in sepsis-induced lung injury

International Immunopharmacology, Journal Year: 2021, Volume and Issue: 99, P. 107914 - 107914

Published: July 8, 2021

Language: Английский

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Severe COVID-19 Is Characterized by an Impaired Type I Interferon Response and Elevated Levels of Arginase Producing Granulocytic Myeloid Derived Suppressor Cells

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: July 14, 2021

COVID-19 ranges from asymptomatic in 35% of cases to severe 20% patients. Differences the type and degree inflammation appear determine severity disease. Recent reports show an increase circulating monocytic-myeloid-derived suppressor cells (M-MDSC) COVID 19 that deplete arginine but are not associated with respiratory complications. Our data shows differences type, function transcriptome granulocytic-MDSC (G-MDSC) may part explain COVID-19, particular association pulmonary Large infiltrates by Arginase 1 + G-MDSC (Arg G-MDSC), expressing NOX-1 NOX-2 (important for production reactive oxygen species) were found lungs patients who died Increased Arg depleted arginine, which impaired T cell receptor endothelial function. Transcriptomic signatures different stages revealed had increased expression pathways genes I interferon (IFN), while arginase production, granulocyte degranulation These results suggest develop a protective IFN response, have inflammatory response depletes impairs function, causes extensive damage. Therefore, inhibition arginase-1 and/or replenishment be important preventing/treating COVID-19.

Language: Английский

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Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG): A Time for a New Player in the Treatment of Respiratory Diseases?

Antioxidants, Journal Year: 2022, Volume and Issue: 11(8), P. 1566 - 1566

Published: Aug. 13, 2022

(-)-Epigallocatechin-3-gallate (EGCG) is a major polyphenol of green tea that possesses wide variety actions. EGCG acts as strong antioxidant which effectively scavenges reactive oxygen species (ROS), inhibits pro-oxidant enzymes including NADPH oxidase, activates systems superoxide dismutase, catalase, or glutathione, and reduces abundant production nitric oxide metabolites by inducible synthase. ECGC also exerts potent anti-inflammatory, anti-fibrotic, pro-apoptotic, anti-tumorous, metabolic effects via modulation intracellular signaling cascades. Based on this knowledge, the use could be benefit in respiratory diseases with acute chronic inflammatory, oxidative, fibrotizing processes their pathogenesis. This article reviews current information biological those animal models has been administered, i.e., distress syndrome, infections, COVID-19, bronchial asthma, obstructive pulmonary disease, lung fibrosis, silicosis, cancer, hypertension, embolism, critically discusses effectiveness administration these disorders. For review, articles English language from PubMed database were used.

Language: Английский

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