Therapeutic functions of medical implants from various material categories with integrated biomacromolecular systems DOI Creative Commons
Guilherme Bedeschi Calais,

Guillermina Garcia,

Celso Fidelis de Moura Júnior

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 10, 2025

Medical implants are designed to replace missing parts or improve body functions and must be capable of providing structural support therapeutic intervention for a medical condition. Advances in materials science have enabled the development devices made from metals, polymers, bioceramics, composites, each with its specific advantages limitations. This review analyzes incorporation biopolymers, proteins, other biomacromolecules into implants, focusing on their role biological integration functions. It synthesizes advancements surface modification, discusses as carriers controlled drug release, explores application nanoceramics composites osseointegration tissue regeneration. Biomacromolecule systems interacting device components agents - such growth factors (GFs), antibiotics, allowing control over substance release. Incorporating these enables localized treatments regeneration, osseointegration, post-surgery infection control, disease pre-existing conditions. The highlights materials' customization opportunities, by covering mechanical perspectives. Developing hybrid delivery align recent efforts interdisciplinary personalized medicine implant innovations. For instance, trend was observed integrating inorganic (especially nanoceramics, e.g., hydroxyapatite) organic phases better interaction tissues faster recovery. article supports understanding how can create more personalized, functional, durable, biocompatible devices.

Language: Английский

Therapeutic functions of medical implants from various material categories with integrated biomacromolecular systems DOI Creative Commons
Guilherme Bedeschi Calais,

Guillermina Garcia,

Celso Fidelis de Moura Júnior

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 10, 2025

Medical implants are designed to replace missing parts or improve body functions and must be capable of providing structural support therapeutic intervention for a medical condition. Advances in materials science have enabled the development devices made from metals, polymers, bioceramics, composites, each with its specific advantages limitations. This review analyzes incorporation biopolymers, proteins, other biomacromolecules into implants, focusing on their role biological integration functions. It synthesizes advancements surface modification, discusses as carriers controlled drug release, explores application nanoceramics composites osseointegration tissue regeneration. Biomacromolecule systems interacting device components agents - such growth factors (GFs), antibiotics, allowing control over substance release. Incorporating these enables localized treatments regeneration, osseointegration, post-surgery infection control, disease pre-existing conditions. The highlights materials' customization opportunities, by covering mechanical perspectives. Developing hybrid delivery align recent efforts interdisciplinary personalized medicine implant innovations. For instance, trend was observed integrating inorganic (especially nanoceramics, e.g., hydroxyapatite) organic phases better interaction tissues faster recovery. article supports understanding how can create more personalized, functional, durable, biocompatible devices.

Language: Английский

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