Prevalence and correlates of suicide attempts in working-age, first-episode, drug-naïve major depressive disorder patients DOI

Liyan Wang,

Qinfeng Xiao,

Changwei Hu

et al.

Published: May 7, 2025

Abstract Suicide attempts are a critical concern among first-episode, drug-naïve (FEDN) patients with major depressive disorder (MDD). This cross-sectional study investigated the prevalence and predictors of suicide in 1701 working-age Chinese adults (18–59 years) FEDN MDD. Sociodemographic data, clinical assessments, biochemical data were obtained. Overall, 20.2% participants reported lifetime history attempts. Multiple logistic regression identified four independent attempts: Hamilton Anxiety Scale (HAMA), global impression severity scale (CGI-s), systolic blood pressure, thyroid peroxidase antibody levels. Receiver operating characteristic curve analysis further highlighted high discriminative ability HAMA CGI-s for predicting Taken together, these findings underscore importance integrating psychological biological markers routine risk evaluation MDD patients. Incorporating assessment anxiety, autoantibody may enhance early detection high-risk individuals inform targeted intervention strategies.

Language: Английский

Prevalence and correlates of suicide attempts in working-age, first-episode, drug-naïve major depressive disorder patients DOI

Liyan Wang,

Qinfeng Xiao,

Changwei Hu

et al.

Published: May 7, 2025

Abstract Suicide attempts are a critical concern among first-episode, drug-naïve (FEDN) patients with major depressive disorder (MDD). This cross-sectional study investigated the prevalence and predictors of suicide in 1701 working-age Chinese adults (18–59 years) FEDN MDD. Sociodemographic data, clinical assessments, biochemical data were obtained. Overall, 20.2% participants reported lifetime history attempts. Multiple logistic regression identified four independent attempts: Hamilton Anxiety Scale (HAMA), global impression severity scale (CGI-s), systolic blood pressure, thyroid peroxidase antibody levels. Receiver operating characteristic curve analysis further highlighted high discriminative ability HAMA CGI-s for predicting Taken together, these findings underscore importance integrating psychological biological markers routine risk evaluation MDD patients. Incorporating assessment anxiety, autoantibody may enhance early detection high-risk individuals inform targeted intervention strategies.

Language: Английский

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