Steroid-hormone receptors in breast cancer

Cancer, Journal Year: 1984, Volume and Issue: 53(S3), P. 630 - 643

Published: Feb. 1, 1984

An obvious problem for the surgeon or oncologist treating breast cancer has been to identify patients likely respond endocrine manipulation. Until recently, clinical factors such as previous response hormone therapy, disease-free interval, age and menopausal status, location of dominant metastatic lesion were principal criteria selecting therapeutic regimens these women. Recently, measurement steroid receptors become an important laboratory test. Progress during last decade shown that: most reliable methods determining estrogen (ER) progestin (PR) are multipoint titration analysis using dextran-coated charcoal, sucrose density gradient centrifugation; 55% 65% primary tumors contain more than 10 femtomole/mg cytosol protein ER; 45% fmol/mg ER present often in postmenopausal women compared with those premenopausal women; benign lesions fibrocystic disease fibroadenomas usually less 90% male carcinomas approximately containing objectively either additive ablative; 3% lacking therapy. In addition, it suggested that absence a tumor correlates well increased cytotoxic chemotherapy; 60% PR. Also, presence both PR indicates 75% 80% likelihood patient will manipulation, 8 Svedberg form (as detected by centrifugation) improves accuracy therapy; there appears be relationship between quantity patient's The incidence therapy increases increasing levels.

Language: Английский

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Reliability of steroid hormone receptor assays: an international study

European Journal of Cancer and Clinical Oncology, Journal Year: 1983, Volume and Issue: 19(3), P. 357 - 363

Published: March 1, 1983

Language: Английский

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Radioimmunodetection of colorectal cancer

Cancer, Journal Year: 1980, Volume and Issue: 45(S5), P. 1243 - 1247

Published: March 15, 1980

This study examines the accuracy of colorectal cancer radioimmunodetection. Twenty-seven patients with a history histologically-confirmed colonic or rectal carcinoma received high-titer, purified goat anti-CEA IgG labelled 131-I at total dose least 1.0 muCi. Various body views were scanned 24 and 48 hours after administration radioantibody. Three additional cases evaluated; one had villous adenoma in rectum 131-I-labelled IgG, while two normal 131-I. All 7 primary showed true-positive tumor localization, 20 25 sites metastatic detected by immune scintigraphy corroborated other detection measures. The sensitivity radioimmunodetection cancers (primary metastatic) was found to be 90% (true-positive rate), putative specificity (true-negative rate) 94%, appraent overall technique 93%. Neither case receiving nor radiolocalization. Very high circulating CEA titers did not appear hinder successful These findings suggest that method may value preoperatively determining location extent disease, assessing possible recurrence spread postoperatively, localizing source production rising elevated titers. An ancilliary benefit could more tumor-specific test for confirming other, conventional diagnostic

Language: Английский

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IN VIVO‐IN VITRO RAT LIVER CARCINOGENESIS: MODIFICATIONS IN PROTEIN SYNTHESIS AND ULTRASTRUCTURE*

Annals of the New York Academy of Sciences, Journal Year: 1980, Volume and Issue: 349(1), P. 357 - 372

Published: Sept. 1, 1980

Language: Английский

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Steroid receptor interactions in human breast carcinoma

Cancer, Journal Year: 1980, Volume and Issue: 46(S12), P. 2953 - 2960

Published: Dec. 15, 1980

Sucrose gradient centrifugation of estrogen and progestin receptors in cytosol preparations revealed that the majority human breast tumors contained two molecular forms sedimenting at either 8S or 4S. Few exhibited profiles containing predominately form 4S alone. Molecular heterogeneity was demonstrated with regard to surface charge using ion-exchange chromatography isoelectric focusing. The properties tumor biopsy specimens appear be related clinical responsiveness patients given hormonal manipulations. These data other findings utility steroid receptor quantification impose a requirement for rigid quality control analyses by laboratory. composition, evaluation, distribution tissue reference powders establishing uniformity used cooperative trials cancer treatment are described. This approach ensures meaningful correlations between laboratory results response.

Language: Английский

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Tumor Radioimmunolocalization in a Murine System using Monoclonal Antibodies

Tumori Journal, Journal Year: 1983, Volume and Issue: 69(3), P. 185 - 190

Published: June 1, 1983

Tumor localization was obtained in a murine system by use of 131 I-labeled monoclonal antibodies, both IgG and IgM class. The A6 2 antibody (which recognizes the gp70 MuLV) B3 proteic structure widely exposed on chemically induced tumors), which manifest an vitro cytotoxic activity for various types lymphomas, were injected tumor-bearing (B6 × BALB/c)F 1 mice B6 mice, respectively, at dose μg per mouse. radioactivity count demonstrated optimal tumor accumulation radiolabeled antibodies 96 h after iodine injection, although initial already present 48 injection. scanning detection less sensitive, since no possible. In experiments with antibody, presence circulating form, immunocomplexes kidney spleen A6, did not prevent tumor. This found to increase size only up g weight, then decreased binding index observed, whereas progressive paralleled weight.

Language: Английский

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Roles of nutrition, obesity, and estrogens in diabetes mellitus: Human leads to an experimental approach to prevention

Preventive Medicine, Journal Year: 1981, Volume and Issue: 10(5), P. 577 - 589

Published: Sept. 1, 1981

Language: Английский

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Metallo-Organic Complexes and Carcinogenesis

Topics in molecular organization and engineering, Journal Year: 1989, Volume and Issue: unknown, P. 87 - 108

Published: Jan. 1, 1989

Language: Английский

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Certain Trace Metal Disorders in Urinary Bladder of Bilharzial Patients suffering Bladder Carcinoma

Isotopenpraxis Isotopes in Environmental and Health Studies, Journal Year: 1991, Volume and Issue: 27(7), P. 328 - 331

Published: Jan. 1, 1991

The objective of the present work is to investigate any possible role which could have been played by long-term treatment with antimony as an antibilharzial drug, and development urinary bladder carcinoma in patients suffering bilharzial complications. has planned concentration levels copper, zinc tissues sampled from normal, cancer subjected surgical intervention. Both atomic absorption spectrophotometry neutron activation analysis utilized for elemental estimations. data obtained showed significant increase three investigated metals tumours compared their control under either normal or cancer-free results statistically evaluated discussed view relevant literature. It concluded that contributing antimonial cases cannot be overlooked awaits further investigation.

Language: Английский

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