Respiratory Physiology & Neurobiology, Journal Year: 2024, Volume and Issue: 331, P. 104346 - 104346
Published: Sept. 11, 2024
Language: Английский
International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(6), P. 1992 - 2007
Published: Jan. 1, 2024
Objective: Osteoarthritis (OA) is the most prominent chronic arthritic disease, affecting over 3 billion people globally.Synovial macrophages, as immune cells, play an essential role in cartilage damage OA.Therefore, regulating macrophages crucial for controlling pathological changes OA.Triggering receptor expressed on myeloid cells 2 (TREM2), cell surfaces, such and dendritic has suppressed inflammation regulated M2 macrophage polarization but demonstrated unknown synovial OA.This study aimed to investigate TREM2 expression downregulation OA mice macrophages.Furthermore, trend of was associated with polarization-related molecule mice.Results: We used knockout (TREM2-KO) observe that deficiency significantly exacerbated joint response mice, thereby accelerating disease progression.Separating chondrocytes from TREM2-KO co-cultivating them increased chondrocyte apoptosis inhibited proliferation.Further, also enhanced phosphatidylinositol 3-kinase(PI3K)/AKT signaling pathway activation, increasing nuclear factor kappa light chain enhancer activated B (NF-κB) C-X-C Motif Chemokine Ligand (CXCL3) expression.Furthermore, NF-κB inhibition arthritis effectively alleviating deficiency-related adverse effects chondrocytes.Notably, knocking down CXCL3 inhibits inflammatory promotes proliferation.Intravenous recombinant protein (soluble TREM2, sTREM2) injection markedly M1 improves tissue pathology OA.Conclusion: Our reveals during by NF-κB/CXCL3 axis regulation, improving state OA.
Language: Английский
Citations
24
Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 192 - 192
Published: Jan. 29, 2025
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a pulmonary disease with high mortality associated inflammation. During the development of ALI/ARDS, macrophages usually polarize toward M1 pro-inflammatory macrophages, promoting inflammatory response in ALI/ARDS and aggravating tissue damage. Natural compounds anti-inflammatory activity have achieved excellent results treatment through different regulatory modes, including macrophage polarization. Of note, flavonoid, brevilin A, tetrahydropalmatine play an important role by modulating phenotypic polarization their cytokine expression innate immune cells lung. Flavonoids are kind naturally occurring polyphenol compound, which has antioxidant activities. Studies found that some flavonoids can alleviate inhibiting cytokines macrophages. Among them, 5-methoxyflavone, acacetin, grape seed proanthocyanidins, luteolin also regulate Therefore, in-depth exploration mechanism lay foundation for application alleviating inflammation-related injury. This review focuses on effects natural potential mechanisms ALI/ARDS.
Language: Английский
Citations
0
Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1395 - 1412
Published: Jan. 1, 2025
Explore the therapeutic effect and molecular mechanism of rhein on severe acute pancreatitis associated lung injury (SAP-ALI). The SAP-ALI rat model was constructed by retrograde injection 5% sodium taurocholate into pancreaticobiliary duct, pulmonary microvascular endothelial cell (PMVEC) induced LPS. potential effects appropriate dosages PMVEC were investigated in both vivo vitro experiments. Furthermore, regulatory role MARK4 related pathological process confirmed some experimental methods. RNA sequencing analysis performed to explore downstream genes MARK4. Moreover, validated through docking rescue Rhein intervention had triggered SAP may contribute modulation microtubule structure. Compared with LPS stimulation, a total 2081 differentially expressed identified after knockdown. results experiments indicated that exert its protective targeting regulate structure MARK4, thereby alleviating LPS-induced injury.
Language: Английский
Citations
0
Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)
Published: Feb. 5, 2025
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 150, P. 114247 - 114247
Published: Feb. 12, 2025
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 2, 2025
Triggering receptors expressed on myeloid cells 2 (TREM2), an immune receptor cells, has garnered considerable attention in recent years due to its role unique signaling pathways and diverse biological functions, including phagocytosis, lipid metabolism, cell survival, inflammatory responses. Although TREM2 is various types, such as macrophages, dendritic (DCs), osteoclasts, others, where it exhibits context-dependent functional characteristics, mainly macrophages. Notably, implicated the development progression of multiple diseases, playing dual often opposing roles noncancerous diseases cancers. This review aims highlight pivotal macrophages immune-related elucidate underlying mechanisms action, explore potential a clinical diagnostic prognostic marker, propose therapeutic strategies targeting based current trial data, providing comprehensive guidance references for practice.
Language: Английский
Citations
0
Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 319, P. 117227 - 117227
Published: Sept. 24, 2023
Language: Английский
Citations
7
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1665 - 1665
Published: Dec. 10, 2024
Rhein is a natural active ingredient in traditional Chinese medicine that has attracted much attention due to its wide range of pharmacological activities. However, clinical application limited by low water solubility, poor oral absorption, and potential toxicity the liver kidneys. Recently, advanced extraction synthesis techniques have made it possible develop derivatives rhein, which better properties lower toxicity. This article comprehensively summarizes biological activity action mechanism rhein. Notably, we found TGF-
Language: Английский
Citations
2
Bioorganic & Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 117895 - 117895
Published: Sept. 1, 2024
Language: Английский
Citations
1
Clinical and Experimental Pharmacology and Physiology, Journal Year: 2024, Volume and Issue: 51(11)
Published: Oct. 3, 2024
Abstract Sepsis‐induced acute lung injury (ALI) is characterized by inflammatory damage to pulmonary endothelial and epithelial cells. The aim of this study probe the significance mechanism tripartite motif‐containing protein 21 ( TRIM21 ) in sepsis‐induced ALI. ALI mouse model was established cecum ligation puncture. mice were infected with lentivirus treated proteasome inhibitor MG132. respiratory damage, levels interleukin‐6 (IL‐6), tumour necrosis factor α (TNF‐α), IL‐10 pathological changes observed. expression , interferon regulatory factors 1 IRF1 triggering receptor expressed on myeloid cells 2 TREM2 measured their interactions analysed. ubiquitination level detected. downregulated upregulated mice. overexpression eased inflammation injury. promoted degradation via modification. bonded promoter inhibit its transcription. Overexpression or silencing reversed improvement In conclusion, reduced improve ameliorate
Language: Английский
Citations
1