Cancer-Associated Programmed Cell Death Mechanisms: Extended with Biochemical Markers and Experimental Approaches DOI
Goksemin Fatma Sengul,

Fatma Secer-Celik,

Gaye Pisiren

et al.

Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Anti-Inflammatory Role of the Klotho Protein and Relevance to Aging DOI Open Access
Gérald J. Prud’homme, Qinghua Wang

Published: Aug. 5, 2024

The α-Klotho protein (hereafter Klotho) is an obligate coreceptor for fibroblast growth factor 23 (FGF23). It produced in the kidneys, brain and other sites. Klotho insufficiency causes hyperphosphatemia anomalies. Importantly, it associated with chronic pathologies (often age-related) that have inflammatory component. This includes atherosclerosis, diabetes Alzheimer’s disease. Its mode of action these diseases not well understood, but inhibits or regulates multiple major pathways. has a membrane form, soluble form (s-Klotho). Cytosolic postulated characterized. s-Klotho endocrine properties are incompletely elucidated. binds to FGF receptor 1c (FGFR1c) widely expressed (including endothelial cells). also attaches FGF23, FGF23/Klotho FGFRs. Thus, might be roaming FGF23 coreceptor, functions. Notably, (cell-bound soluble) counteracts inflammation, appears mitigate related aging (inflammaging). NF-κB NLRP3 inflammasome. inflammasome requires priming by NF-κB, produces active IL-1β, pores cell death (pyroptosis). In accord, countered inflammation injury induced toxins, damage-associated molecular patterns (DAMPs), cytokines, reactive oxygen species (ROS). blocks TGF-β Wnt ligands, which lessens fibrotic Low loss muscle mass (sarcopenia), as occurs diseases. counters inhibitory effects myostatin on muscle, reduces improves repair following injury. Inhibition factors may protective diabetic retinopathy age-related macular degeneration (AMD). review examines functions especially potential applications.

Language: Английский

Citations

3
Copper induced cytosolic escape of mitochondrial DNA and activation of cGAS-STING-NLRP3 pathway-dependent pyroptosis in C8-D1A cells DOI Creative Commons
Wei Shi, Qian Zhou, Lu Lu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 285, P. 117085 - 117085

Published: Sept. 24, 2024

Language: Английский

Citations

3
HIF-1α facilitates glioma proliferation and invasion by activating pyroptosis signaling axis DOI Creative Commons
Xin Wei Wang, Hao Fu, Yamin Zhang

et al.

Chinese Neurosurgical Journal, Journal Year: 2024, Volume and Issue: 10(1)

Published: May 11, 2024

Abstract Background HIF-1α is thought to be a novel regulator which contributes carcinogenesis. However, the mechanism underlying effect of in gliomas remains largely unknown. Methods In research, we demonstrate that HIF-lα mRNA and protein levels are elevated glioma cells. The colony formation assays, transwell wound-healing assays showed overexpression promoted proliferation invasion Results Overexpression also increased expression inflammatory factors related pyrolysis (TNF-α, IL-10, IL-1β) signal pathway (NLRP3, ASC, caspase-1, GSDMD, GSDME). Conclusions Therefore, speculate promotes glial cells by regulating pathway. These results might provide strategy target for treatment glioma.

Language: Английский

Citations

1
Non-coding RNAs as a Critical Player in the Regulation of Inflammasome in Inflammatory Bowel Diseases; Emphasize on lncRNAs DOI

H. Abed,

Enwa Felix Oghenemaro,

Aziz Kubaev

et al.

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 19, 2024

Language: Английский

Citations

1
Cancer-Associated Programmed Cell Death Mechanisms: Extended with Biochemical Markers and Experimental Approaches DOI
Goksemin Fatma Sengul,

Fatma Secer-Celik,

Gaye Pisiren

et al.

Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

1