Use of Caenorhabditis elegans to Unravel the Tripartite Interaction of Kynurenine Pathway, UPRmt and Microbiome in Parkinson’s Disease DOI Creative Commons

Charles Viau,

Alyssa Nouar,

Jianguo Xia

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1370 - 1370

Published: Oct. 28, 2024

The model organism Caenorhabditis elegans and its relationship with the gut microbiome are gaining traction, especially for study of neurodegenerative diseases such as Parkinson’s Disease (PD). Gut microbes known to be able alter kynurenine metabolites in host, directly influencing innate immunity C. elegans. While mitochondrial unfolded protein response (UPRmt) was first characterized 2007, relevance host–microbiome interactions has only become apparent recent years. In this review, we provide novel insights into current understanding microbiome–gut–brain axis a focus on tripartite between UPRmt, pathway, elegans, explore their relationships PD remediations.

Language: Английский

Protective effects of Abrus cantoniensis Hance against liver injury through modulation of intestinal microbiota and liver metabolites DOI Creative Commons
Chang Xu, Munwar Ali,

Jingyi Sun

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 279, P. 116495 - 116495

Published: May 30, 2024

Abrus cantoniensis Hance (ACH) is an ancient Chinese medicine herb known for its therapeutic effects. This study investigated the potential protective effect of ACH against carbon tetrachloride (CCl

Language: Английский

Citations

6
Exercise-induced adaptations in the kynurenine pathway: implications for health and disease management DOI Creative Commons
Marcus Vinícius dos Santos Rangel, Karynne Grutter Lopes, Xuebin Qin

et al.

Frontiers in Sports and Active Living, Journal Year: 2025, Volume and Issue: 7

Published: March 6, 2025

Background Tryptophan (TRP) metabolism through the kynurenine (KYN) pathway is influenced by inflammatory mediators, generating metabolites that regulate immune and responses. Exercise has been proposed as a modulator of this pathway, but its role in health benefits chronic disease management remains unclear. Objective This systematic review examines exercise-induced adaptations KYN their potential implications for management. Additionally, we identify key methodological considerations future research. Methods A structured search PubMed/Medline, Web Science, Scopus was conducted up to October 2024 clinical trials investigating effects exercise training on pathway. Results Of 2,795 articles initially found, 13 involving 592 participants met inclusion criteria. Most studies reported particularly cancer survivors. These appeared be intensity duration. However, several limitations were noted, no included patients with metabolic or cardiovascular diseases. Conclusions Here, show modulates both healthy diseased populations, highlighting prevention further randomized-controlled are needed clarify mechanisms applications, Systematic Review Registration https://www.crd.york.ac.uk/PROSPERO/view/CRD42022351481 , PROSPERO (CRD42022351481).

Language: Английский

Citations

0
Therapeutic Mechanism of Kynurenine, a Metabolite of Probiotics, on Atopic Dermatitis in Mice DOI Creative Commons
Yixuan Li, Mingxin Li, Qingyu Ren

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(10), P. 1816 - 1816

Published: May 20, 2025

Atopic Dermatitis (AD) is a common inflammatory skin disease characterized primarily by its chronic and recurrent nature. This has significant impact on productivity human longevity. Dysbiosis of gut flora been demonstrated to be significantly associated with the progression AD. In our previous research, it was shown that Lactobacillus rhamnosus RL5-H3-005 (RL) Pediococcus acidilactici RP-H3-006 (RP) have ability reduce risk in AD mice through gut–mammary axis. Based work, this study aims further investigate effects kynurenine (KYN), metabolite RL RP, induced 2, 4-dinitrofluorobenzene (DNFB). study, we found supplementing KYN effectively alleviates pathological symptoms atopic dermatitis improves levels SCFAs their intestines. Further research indicates KYN’s therapeutic are manifested reduction secretory immunoglobulin A (sIgA), E (IgE), interleukin-4 (IL-4), IL-5, IL-13, thymic stromal lymphopoietin (TSLP) mice, while also repairing intestinal barrier function mice. Overall, metabolites probiotics RP can regulate potentially improving gut–skin

Language: Английский

Citations

0
Kynurenine Pathway after Kidney Transplantation: Friend or Foe? DOI Open Access
Izabela Zakrocka, Ewa M. Urbańska, Wojciech Załuska

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9940 - 9940

Published: Sept. 14, 2024

Kidney transplantation significantly improves the survival of patients with end-stage kidney disease (ESKD) compared to other forms replacement therapy. However, transplant recipients’ outcomes are not fully satisfactory due increased risk cardiovascular diseases, infections, and malignancies. Immune-related complications remain biggest challenge in management graft recipients. Despite broad spectrum immunosuppressive agents available more detailed methods used monitor their effectiveness, chronic allograft nephropathy remains most common cause rejection. The kynurenine (KYN) pathway is main route tryptophan (Trp) degradation, resulting production a plethora substances ambiguous properties. Conversion Trp KYN by enzyme indoleamine 2,3-dioxygenase (IDO) rate-limiting step determining formation next from pathway. IDO activity, as well subsequent metabolites pathway, highly dependent on balance between pro- anti-inflammatory conditions. Moreover, products themselves possess immunomodulating properties, e.g., modify activity control immune-related processes. were widely studied neurological disorders but recently gained attention researchers context immune-mediated diseases. Evidence that this degradation may represent peripheral tolerogenic significant implications for further fueled interest. Our review aimed present recent knowledge about role pathogenesis, diagnosis, monitoring, treatment complications.

Language: Английский

Citations

2
Use of Caenorhabditis elegans to Unravel the Tripartite Interaction of Kynurenine Pathway, UPRmt and Microbiome in Parkinson’s Disease DOI Creative Commons

Charles Viau,

Alyssa Nouar,

Jianguo Xia

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1370 - 1370

Published: Oct. 28, 2024

The model organism Caenorhabditis elegans and its relationship with the gut microbiome are gaining traction, especially for study of neurodegenerative diseases such as Parkinson’s Disease (PD). Gut microbes known to be able alter kynurenine metabolites in host, directly influencing innate immunity C. elegans. While mitochondrial unfolded protein response (UPRmt) was first characterized 2007, relevance host–microbiome interactions has only become apparent recent years. In this review, we provide novel insights into current understanding microbiome–gut–brain axis a focus on tripartite between UPRmt, pathway, elegans, explore their relationships PD remediations.

Language: Английский

Citations

0