Design of therapeutic biomaterials to control inflammation

Nature Reviews Materials, Journal Year: 2022, Volume and Issue: 7(7), P. 557 - 574

Published: Feb. 28, 2022

Language: Английский

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Neuronal regulation of the blood–brain barrier and neurovascular coupling

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(8), P. 416 - 432

Published: July 7, 2020

Language: Английский

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Targeting the transferrin receptor for brain drug delivery

Progress in Neurobiology, Journal Year: 2019, Volume and Issue: 181, P. 101665 - 101665

Published: July 31, 2019

Language: Английский

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The blood–tumour barrier in cancer biology and therapy

Nature Reviews Clinical Oncology, Journal Year: 2021, Volume and Issue: 18(11), P. 696 - 714

Published: July 12, 2021

Language: Английский

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Key for crossing the BBB with nanoparticles: the rational design

Beilstein Journal of Nanotechnology, Journal Year: 2020, Volume and Issue: 11, P. 866 - 883

Published: June 4, 2020

Central nervous system diseases are a heavy burden on society and health care systems. Hence, the delivery of drugs to brain has gained more interest. The is protected by blood–brain barrier (BBB), selective formed endothelial cells cerebral microvessels, which at same time acts as bottleneck for drug preventing vast majority reach brain. To overcome this obstacle, can be loaded inside nanoparticles that carry through BBB. However, not all particles able cross BBB multitude factors needs taken into account when developing carrier purpose. Depending chosen pathway BBB, nanoparticle material, size surface properties such functionalization charge should tailored fit specific route crossing.

Language: Английский

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Solid Lipid Nanoparticles (SLNs): An Advanced Drug Delivery System Targeting Brain through BBB

Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(8), P. 1183 - 1183

Published: July 31, 2021

The blood–brain barrier (BBB) plays a vital role in the protection and maintenance of homeostasis brain. In this way, it is an interesting target as interface for various types drug delivery, specifically context treatment several neuropathological conditions where therapeutic agents cannot cross BBB. Drug toxicity on-target specificity are among some limitations associated with current neurotherapeutics. recent years, advances nanodrug delivery have enabled carrier system containing active to signaling pathways pathophysiology that closely linked central nervous (CNS) disorders such Alzheimer’s disease (AD), Parkinson’s (PD), Huntington’s (HD), multiple sclerosis (MS), brain tumor, epilepsy, ischemic stroke, neurodegeneration. At present, nano formulations, solid lipid nanoparticles (SLNs) emerged putative can deliver therapeutics (drug-loaded SLNs) across BBB at site brain, offering novel approach controlled longer circulation time, specificity, higher efficacy, more importantly, reducing biomimetic way. This paper highlights synthesis application SLNs nontoxic formulation strategy carry CNS drugs improve use treating major neurological future clinics.

Language: Английский

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Advances in nanomaterial-based targeted drug delivery systems

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: April 13, 2023

Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety and therapeutic efficacy of encapsulated drugs due their unique physicochemical biological properties. By combining with nanoparticles using rational targeting pathways, nano-targeted were created overcome main drawbacks conventional treatment, including insufficient stability solubility, lack transmembrane transport, short circulation time, undesirable toxic effects. Herein, we reviewed recent developments in different design strategies approaches employing various nanomaterial-based systems. We also discussed challenges perspectives smart precisely intravascular extravascular diseases.

Language: Английский

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Rethinking CRITID Procedure of Brain Targeting Drug Delivery: Circulation, Blood Brain Barrier Recognition, Intracellular Transport, Diseased Cell Targeting, Internalization, and Drug Release

Advanced Science, Journal Year: 2021, Volume and Issue: 8(9)

Published: Feb. 24, 2021

Abstract The past decades have witnessed great progress in nanoparticle (NP)‐based brain‐targeting drug delivery systems, while their therapeutic potentials are yet to be fully exploited given that the majority of them lost during process. Rational design systems requires a deep understanding entire process along with issues they may encounter. Herein, this review first analyzes typical systemically administrated NPs‐based system and proposes six‐step CRITID cascade: circulation systemic blood, recognizing receptor on blood‐brain barrier (BBB), intracellular transport, diseased cell targeting after entering into parenchyma, internalization by cells, finally release. By dissecting six steps, seeks provide restrict efficiency as well specific requirements guarantee minimal loss at each step. Currently developed strategies used for troubleshooting these reviewed some state‐of‐the‐art features meeting highlighted. cascade can serve guideline designing more efficient systems.

Language: Английский

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The “Neuro-Glial-Vascular” Unit: The Role of Glia in Neurovascular Unit Formation and Dysfunction

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 9

Published: Sept. 27, 2021

The neurovascular unit (NVU) is a complex multi-cellular structure consisting of endothelial cells (ECs), neurons, glia, smooth muscle (SMCs), and pericytes. Each component closely linked to each other, establishing structural functional unit, regulating central nervous system (CNS) blood flow energy metabolism as well forming the blood-brain barrier (BBB) inner blood-retina (BRB). As name suggests, "neuro" "vascular" components NVU are recognized coupling key function NVU. However, consists multiple cell types its functionality goes beyond resulting coupling, with cross-component links signaling, metabolism, homeostasis. Within NVU, glia have gained increased attention it increasingly clear that they fulfill various multi-level functions in Glial dysfunctions were shown precede neuronal vascular pathologies suggesting roles for pathogenesis disease. In this review, we take "glio-centric" view on development retina brain, how these change disease, advancing experimental techniques will help us address unanswered questions.

Language: Английский

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Exosomal delivery of therapeutic modulators through the blood–brain barrier; promise and pitfalls

Cell & Bioscience, Journal Year: 2021, Volume and Issue: 11(1)

Published: July 22, 2021

Abstract Nowadays, a large population around the world, especially elderly, suffers from neurological inflammatory and degenerative disorders/diseases. Current drug delivery strategies are facing different challenges because of presence BBB, which limits transport various substances cells to brain parenchyma. Additionally, low rate successful cell transplantation injury sites leads efforts find alternative therapies. Stem byproducts such as exosomes touted natural nano-drug carriers with 50–100 nm in diameter. These nano-sized particles could harbor transfer plethora therapeutic agents biological cargos brain. nanoparticles would offer solution maintain paracrine cell-to-cell communications under healthy conditions. The main question is that existence intact BBB limit exosomal trafficking. Does possess some molecular mechanisms facilitate compared circulating cell? Although preliminary studies have shown cross exact mechanism(s) beyond this phenomenon remains unclear. In review, we tried compile facts about exosome through propose regulate pathological physiological

Language: Английский

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