Frontiers in Physiology,
Journal Year:
2023,
Volume and Issue:
14
Published: May 30, 2023
Progressive
muscle
weakness
and
degeneration
characterize
Duchenne
muscular
dystrophy
(DMD),
a
lethal,
x-linked
neuromuscular
disorder
that
affects
1
in
5,000
boys.
Loss
of
dystrophin
protein
leads
to
recurrent
degeneration,
progressive
fibrosis,
chronic
inflammation,
dysfunction
skeletal
resident
stem
cells,
called
satellite
cells.
Unfortunately,
there
is
currently
no
cure
for
DMD.
In
this
mini
review,
we
discuss
how
cells
dystrophic
are
functionally
impaired,
contributes
the
DMD
pathology,
tremendous
potential
restoring
endogenous
cell
function
as
viable
treatment
strategy
treat
debilitating
fatal
disease.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(18), P. 6732 - 6732
Published: Sept. 14, 2020
Sarcopenia
refers
to
a
condition
of
progressive
loss
skeletal
muscle
mass
and
function
associated
with
higher
risk
falls
fractures
in
older
adults.
Musculoskeletal
aging
leads
reduced
strength,
affecting
the
quality
life
elderly
people.
In
recent
years,
several
studies
contributed
improve
knowledge
pathophysiological
alterations
that
lead
dysfunction;
however,
molecular
mechanisms
underlying
sarcopenia
are
still
not
fully
understood.
Muscle
development
homeostasis
require
fine
gene
expression
modulation
by
which
microRNAs
(miRNAs)
play
crucial
role.
miRNAs
modulate
key
steps
myogenesis
including
satellite
cells
renewal,
plasticity,
regeneration.
Here,
we
provide
an
overview
general
aspects
regeneration
role
plasticity
special
interest
their
adaptation
exercise
elderly.
Frontiers in Cell and Developmental Biology,
Journal Year:
2021,
Volume and Issue:
9
Published: Sept. 20, 2021
Embryonic
myogenesis
is
a
temporally
and
spatially
regulated
process
that
generates
skeletal
muscle
of
the
trunk
limbs.
During
this
process,
mononucleated
myoblasts
derived
from
myogenic
progenitor
cells
within
somites
undergo
proliferation,
migration
differentiation
to
elongate
fuse
into
multinucleated
functional
myofibers.
Skeletal
most
abundant
tissue
body
has
remarkable
ability
self-repair
by
re-activating
program
in
stem
cells,
known
as
satellite
cells.
Post-transcriptional
regulation
gene
expression
mediated
RNA-binding
proteins
critically
required
for
development
during
embryogenesis
homeostasis
adult.
Differential
subcellular
localization
activity
orchestrates
target
at
multiple
levels
regulate
different
steps
myogenesis.
Dysfunctions
these
post-transcriptional
regulators
impair
homeostasis,
but
also
cause
defects
motor
neurons
or
neuromuscular
junction,
resulting
degeneration
disease.
Many
proteins,
such
members
blind-like
(MBNL)
CUG-BP
ETR-3-like
factors
(CELF)
families,
display
both
overlapping
distinct
targets
Thus
they
function
either
cooperatively
antagonistically
coordinate
myoblast
proliferation
differentiation.
Evidence
accumulating
dynamic
interplay
their
regulatory
may
control
progression
well
cell
quiescence
activation.
Moreover,
role
modification
far
less
understood
compared
with
transcription
involved
specification
Here
we
review
past
achievements
recent
advances
understanding
functions
development,
regeneration
disease,
aim
identify
fundamental
questions
are
still
open
further
investigations.
Biofabrication,
Journal Year:
2021,
Volume and Issue:
14(1), P. 015009 - 015009
Published: Nov. 17, 2021
3D
printing
is
an
effective
technology
for
recreating
skeletal
muscle
tissuein
vitro.
To
achieve
clinical
injury
repair,
relatively
large
volumes
of
highly
aligned
cells
are
required;
obtaining
these
still
a
challenge.
It
currently
unclear
how
individual
and
their
neighbouring
components
co-ordinate
to
establish
anisotropic
architectures
in
homogeneous
orientations.
Here,
we
demonstrated
strategy
followed
by
sequential
culture
processes
engineer
tissue.
The
effects
confined
on
the
during
maturation,
which
impacted
myotube
alignment,
myogenic
gene
expression,
mechanical
forces,
were
observed.
Our
findings
demonstrate
dynamic
changes
tissue
duringin
vitro3D
construction
reveal
role
physical
factors
orientation
maturity
fibres.
Frontiers in Physiology,
Journal Year:
2023,
Volume and Issue:
14
Published: May 30, 2023
Progressive
muscle
weakness
and
degeneration
characterize
Duchenne
muscular
dystrophy
(DMD),
a
lethal,
x-linked
neuromuscular
disorder
that
affects
1
in
5,000
boys.
Loss
of
dystrophin
protein
leads
to
recurrent
degeneration,
progressive
fibrosis,
chronic
inflammation,
dysfunction
skeletal
resident
stem
cells,
called
satellite
cells.
Unfortunately,
there
is
currently
no
cure
for
DMD.
In
this
mini
review,
we
discuss
how
cells
dystrophic
are
functionally
impaired,
contributes
the
DMD
pathology,
tremendous
potential
restoring
endogenous
cell
function
as
viable
treatment
strategy
treat
debilitating
fatal
disease.
