Bone, Journal Year: 2025, Volume and Issue: unknown, P. 117485 - 117485
Published: April 1, 2025
Language: Английский
Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2023, Volume and Issue: 33(7), P. 1437 - 1443
Published: April 23, 2023
Language: Английский
Citations
55
Cell & Bioscience, Journal Year: 2022, Volume and Issue: 12(1)
Published: May 31, 2022
Abstract Background The global population of older individuals is growing, and ageing a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation senescent cells can cause potentially deleterious effects on the organism with age. As vital marker cellular senescence, senescence-associated secretory phenotype (SASP) novel mechanism to link senescence atherosclerosis. Main body In this review, we concretely describe characteristics SASP its regulation mechanisms. Importantly, provide perspectives how promote from different types have roles in atherosclerosis progression. significant mediator harmful cells, it play pro-atherogenic role by producing inflammation immune dysfunction. Furthermore, deliver signals surrounding vascular gradually contributing development Finally, focus variety therapeutic strategies aimed reduce burden elderly targeting inhibiting regulatory mechanisms SASP. Conclusion This review systematically summarizes multiple contribute exploration new opportunities.
Language: Английский
Citations
60
Frontiers in Cardiovascular Medicine, Journal Year: 2022, Volume and Issue: 8
Published: Jan. 27, 2022
Cardiovascular diseases (CVDs) are still the main cause of morbidity and mortality worldwide include a group disorders varying from vasculature, myocardium, arrhythmias cardiac development. MicroRNAs (miRs) endogenous non-coding RNAs with 18-23 nucleotides that regulate gene expression. The miR-34 family, including miR-34a/b/c, plays vital role in regulation myocardial physiology pathophysiological processes. Recently, miR-34a has been implicated cardiovascular fibrosis, dysfunction related as an essential regulator. Interestingly, there is pivotal link among miR-34a, Smad4/TGF-β1 signaling. Notably, both loss-of-function gain-of-function approaches identified critical roles apoptosis, autophagy, inflammation, senescence remodeling by modulating multifunctional signaling pathways. In this article, we focus on current understanding biogenesis, its biological effects implications for pathologies infarction, heart failure, ischaemia reperfusion injury, cardiomyopathy, atherosclerosis, hypertension atrial fibrillation. Thus, further will aid development effective interventions. Targeting emerged potential therapeutic target diseases.
Language: Английский
Citations
58
Current Atherosclerosis Reports, Journal Year: 2022, Volume and Issue: 24(6), P. 483 - 492
Published: April 11, 2022
Abstract Purpose of the Review In this review, we summarize current insights into versatile roles endothelial cells in atherogenesis. Recent Findings The vascular endothelium represents first barrier that prevents entry lipoproteins and leukocytes vessel wall, thereby controlling two key events pathogenesis atherosclerosis. Disturbance homeostasis increases permeability, inflammation, cellular trans-differentiation, which not only promotes build-up atherosclerotic plaques but is also involved life-threatening thromboembolic complications such as plaque rupture erosion. focus on recent findings lipoprotein transport, transitions, function. Summary By using cutting-edge technologies single-cell sequencing, epigenetics, cell fate mapping, novel regulatory mechanisms phenotypes have been discovered, challenged established concepts activation, led to a different view disease.
Language: Английский
Citations
53
Life Medicine, Journal Year: 2023, Volume and Issue: 2(4)
Published: Aug. 30, 2023
Aging of the vasculature, which is integral to functioning literally all human organs, serves as a fundamental physiological basis for age-related alterations well shared etiological mechanism various chronic diseases prevalent in elderly population. China, home world's largest aging population, faces an escalating challenge addressing prevention and management these conditions. To meet this challenge, Biomarker Consortium China has developed expert consensus on biomarkers vascular (VA) by synthesizing literature insights from scientists clinicians. This provides comprehensive assessment associated with VA presents systemic framework classify them into three dimensions: functional, structural, humoral. Within each dimension, panel recommends most clinically relevant biomarkers. For functional domain, reflecting stiffness endothelial function are highlighted. The structural dimension encompasses metrics structure, microvascular distribution. Additionally, proinflammatory factors emphasized humoral dimension. aim establish foundation assessing extent conducting research related VA, ultimate goal improving health globally.
Language: Английский
Citations
26
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2023, Volume and Issue: 1869(4), P. 166642 - 166642
Published: Jan. 18, 2023
Language: Английский
Citations
25
Journal of Orthopaedic Surgery and Research, Journal Year: 2023, Volume and Issue: 18(1)
Published: March 13, 2023
Osteoarthritis (OA) is the most common degenerative disease in joints among elderly patients. Senescence deeply involved pathogenesis of osteoarthritis. Metformin widely used as first-line drug for Type 2 diabetes mellitus (T2DM), and has great potential treatment other aging-related disorders, including OA. However, role metformin OA not fully elucidated. Therefore, our aim here was to investigate effects on human chondrocytes.After treatment, expression level microRNA-34a SIRT1 chondrocyte were detected with quantitative real-time PCR immunofluorescence staining. Then, mimic small interfering RNA (siRNA) against (siRNA-SIRT1) transfected into chondrocyte. Senescence-associated β-galactosidase (SA-β-gal) staining performed assess senescence. Chondrocyte viability illustrated MTT colony formation assays. Western blot conducted detect P16, IL-6, matrix metalloproteinase-13 (MMP-13), Collagen type II (COL2A1) Aggrecan (ACAN).We found that (1 mM) inhibited while promoted chondrocytes. Both miR-34a mimics siRNA SA-β-gal assay confirmed reduced SA-β-gal-positive rate chondrocytes, transfection or siRNA-SIRT1 reversed it. showed accelerated proliferation, weakened this effect. Furthermore, results from western demonstrated suppressed senescence-associated protein proinflammatory cytokine IL-6 catabolic gene MMP-13 elevated anabolic proteins such Aggrecan, which could be attenuated by mimics.Overall, data suggest regulates senescence proliferation through microRNA-34a/SIRT1 pathway, indicating it a novel strategy treatment.
Language: Английский
Citations
18
Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(4), P. 1105 - 1120
Published: Jan. 30, 2024
Language: Английский
Citations
9
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 370, P. 798 - 810
Published: May 18, 2024
Language: Английский
Citations
7
Genes and Immunity, Journal Year: 2024, Volume and Issue: 25(4), P. 277 - 296
Published: June 22, 2024
Abstract MicroRNAs play a crucial role in regulating the immune responses induced by ischemia/reperfusion injury. Through their ability to modulate gene expression, microRNAs adjust targeting specific genes and signaling pathways. This review focuses on impact of inflammatory pathways triggered during injury highlights inflammation, playing critical pathophysiology Dysregulated expression contributes pathogenesis injury, therefore offers an opportunity restore homeostasis improve patient outcomes. Understanding complex network immunoregulatory could provide novel therapeutic interventions aimed at attenuating excessive inflammation preserving tissue integrity.
Language: Английский
Citations
7