Clinical features, plasma neurotransmitter levels and plasma neurohormone levels among patients with early-stage Parkinson’s disease with sleep disorders

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 18, 2025

Sleep disorders occur frequently among patients with Parkinson's disease (PD). Neurotransmitters and neurosteroids are known to be involved in various neurophysiological processes, including sleep development. We aimed assess the associations of peripheral neurotransmitter neurosteroid levels early-stage PD. Fifty-nine PD 30 healthy controls were enrolled. Demographic clinical data collected, conditions comprehensively assessed questionnaires polysomnography. Blood samples obtained from all participants at 1:00 AM 9:00 AM. The concentrations plasma neurotransmitters neurohormones detected via high-performance liquid chromatography tandem mass spectrometry. common nonmotor symptoms (81.4%) coexisted approximately half patients. Dysautonomia was significantly associated presence multiple disorders. RBD dysautonomia negatively correlated melatonin concentration (r = − 0.40, p 0.002) RLS group had higher PSQI scores, 5-hydroxytryptamine glutamine 0.39, SDB cognitive impairment, a greater body index, lower acetylcholine Combined disturbances is closely related disorders, RBD, EDS, insomnia. Changes neurohormone may development Many people (PD) experience problems. Chemicals called play role regulation. This study looked how these chemicals blood might linked found that problems very (81.4%), about issues. REM behavior disorder (RBD) AM, restless legs syndrome (RLS) poorer quality serotonin different times. Sleep-disordered breathing (SDB) memory problems, weight, Understanding links could help improve treatments for

Language: Английский

Clinical features, plasma neurotransmitter levels and plasma neurohormone levels in sleep disorders among patients with early-stage Parkinson’s disease

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Background: Sleep disorders occur frequently in patients with Parkinson’s disease (PD). Neurotransmitters and neurosteroids are known to be involved various neurophysiological processes, including sleep development. Objective:We aimed assess the association between peripheral neurotransmitter neurosteroid levels early-stage PD. Methods: 59 PD 30 healthy controls were enrolled. Demographic clinical data collected conditions comprehensively assessed questionnaires polysomnography. Blood samples obtained at 1:00 AM 9:00 all participants. The concentrations of plasma neurotransmitters neurohormones detected using high-performance liquid chromatography tandem mass spectrometry. Results: common non-motor symptoms (81.4%) coexisted approximately half patients. Dysautonomia was significantly associated presence multiple disorders. RBD dysautonomia negatively correlated melatonin concentration (r = −0.40, p = 0.002) RLS group had higher PSQI score, 5-hydroxytryptamine glutamine −0.39, p AM. SDB cognitive impairment, body index, lower acetylcholine Conclusion: Combined sleep disturbances frequent closely related disorders, RBD, EDS, insomnia. Changes neurohormone may development

Language: Английский