Cited by Novel reduced heteropolyacid nanoparticles for effective treatment of drug-induced liver injury by manipulating reactive oxygen and nitrogen species and inflammatory signals

A new perspective on liver diseases: focusing on the mitochondria-associated endoplasmic reticulum membranes DOI

Mengyu Guo, Runping Liu,

Fukun Zhang

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: unknown, P. 107409 - 107409

Published: Sept. 1, 2024

Language: Английский

Citations

Clothianidin Exposure Induces Cell Apoptosis via Mitochondrial Oxidative Damage DOI

Wei‐long Cheng,

Zhi‐Hui Zhang, Zhibin Zhang

et al.

Environmental Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

ABSTRACT Clothianidin (CLO) is a high‐frequently detected neonicotinoid pesticide in fruits and vegetables, whose exposure security deserves attention. This study evaluated the apoptotic toxicity of CLO on Caco‐2 cells at doses 100 nM, 10 μM, 1 mM. After exposure, induced to remarkable change signaling proteins that participated process cell apoptosis, including caspase 3, cleaved‐caspase 9. treatment further decrease mitochondrial membrane potential increased protein level cytochrome C. Reactive oxygen species (ROS) intracellular Ca 2+ were also found elevated, indicating an oxidative damage caused by treatment. Moreover, production ROS occurred advance elevation, since inhibiting could recover elevation exposure. The metabolic enzyme P450 3A4 (CYP3A4) was downregulated after CLO. Molecular docking simulation indicated had good binding characteristics with CYP3A4. Amino acid sites Arg105, Arg130, Leu373 CYP3A4, nitro group chlorothiazole structure might be action target. These results induce effect cells, possibly acting through combining its then leading stress damage. Thus, risk factor for human intestinal health.

Language: Английский

Citations

Combined hepatoprotective therapy for experimental alcoholic liver damage DOI

G. A. Ermakova, К. В. Попов, И. М. Быков

et al.

Medical news of the North Caucasus, Journal Year: 2024, Volume and Issue: 19(2)

Published: Jan. 1, 2024

This paper offers a view at an experimental assessment of the effectiveness combined hepatoprotective therapy employed for alcoholic liver damage treatment using sulfur-containing drugs.The study involved five groups rats: Group 1 -intact rats; 2 -animals subjected to alcoholism two months, with no correction carried out; Groups 3, 4 and 5 were rats that given ademetionine (10 mg/100 g/day), lipoic acid g/day) combined, respectively.The studies showed AST LDH activity in animals' blood plasma was 16 % 42 below similar indicators only, yet also statistically reliably lower than values animals 3 4. Combined use came along relatively low total antioxidant activity, which 32-40 control.Yet, it allowed weakest levels product accumulation be arrived through oxidative modifications biomolecules.The level thiobarbituric reactive substances (TBA-reactive substances) measured 46 corresponding marker value 36-40 belonging The obtained data proved higher efficiency involving monotherapy respective drugs.

Language: Английский

Citations

Advances in Mesenchymal Stem Cell Therapy and Natural Antioxidants for Hepatic Fibrosis: A Comprehensive Review DOI

Abeer Kazmi, Tahira Sultana

Deleted Journal, Journal Year: 2024, Volume and Issue: 2, P. 100016 - 100016

Published: March 1, 2024

Liver damage resulting from the administration of various allopathic drugs and their associated toxicity has become a major health problem, leading to hepatic fibrosis, cirrhosis, metabolic disorders. This epidemic condition liver disease represents global cause death morbidity. Although orthotopic transplantation remains vital treatment option for fibrotic conditions, its efficacy is limited by organ scarcity risk immunological rejection. Consequently, alternative therapeutic approaches are urgently needed. Cell-based therapy utilizing mesenchymal stem cells (MSCs) garnered considerable interest as promising modality. MSCs exhibit immunomodulatory properties can differentiate into hepatocytes, thus facilitating regeneration damaged hepatocytes increasing residual hepatocyte proliferation while inhibiting activation or apoptosis stellate cells. However, despite potential benefits, transplanted often low survival rates due inadequate oxidative inflammatory stress resistance. Plants harbor diverse array bioactive compounds known possess hepatoprotective antioxidant properties. Nanomaterials play crucial role in regenerative medicine providing targeted delivery agents scaffolds tissue engineering. In treating liver, nanomaterials help mitigate fibrosis progression promote through controlled release anti-fibrotic growth factors. review highlights synergistic cell-based therapy, natural antioxidants, differentiation factors, nanotechnology combating advancing medicine. These combined offer avenues effectively conditions promoting regeneration.

Language: Английский

Citations

Novel reduced heteropolyacid nanoparticles for effective treatment of drug-induced liver injury by manipulating reactive oxygen and nitrogen species and inflammatory signals DOI

Yongqi Yang,

Qiaohui Chen,

Zerun Liu

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 678, P. 174 - 187

Published: Sept. 1, 2024

Language: Английский

Citations