International Journal of Clinical and Experimental Pathology,
Journal Year:
2024,
Volume and Issue:
17(12), P. 458 - 468
Published: Jan. 1, 2024
B-cell
specific
Moloney
MLV
insertion
site-1
(Bmi-1)
belongs
to
the
polycomb
group
(PcG)
gene
and
is
a
transcriptional
suppressor
maintain
appropriate
expression
patterns
during
development.
To
investigate
whether
Bmi-1
has
corrective
effect
on
bone
senescence
induced
in
Littermate
heterozygous
male
female
mice
(Bmi-1
Our
results
indicated
that
could
proportionally
rescued
suffering
from
aging
by
defects.
plays
an
anti-aging
through
multiple
aspects,
such
as
increasing
osteoblast
formation
decreascing
osteoclast
absorption,
stimulating
proliferation,
reducing
apoptosis,
inhibiting
reactive
oxygen
species
(ROS)
delaying
DNA
damage.
suggested
may
play
fundamental
important
role
correcting
BKO
mice.
At
same
time,
it
provide
theoretical
basis
for
clinical
application
of
bone.
Cells,
Journal Year:
2024,
Volume and Issue:
13(24), P. 2052 - 2052
Published: Dec. 12, 2024
Cellular
rejuvenation
therapies
represent
a
transformative
frontier
in
addressing
age-related
decline
and
extending
human
health
span.
By
targeting
fundamental
hallmarks
of
aging—such
as
genomic
instability,
epigenetic
alterations,
mitochondrial
dysfunction,
cellular
senescence—these
aim
to
restore
youthful
functionality
cells
tissues,
offering
new
hope
for
treating
degenerative
diseases.
Recent
advancements
have
showcased
range
strategies,
including
reprogramming,
senolytic
interventions,
restoration,
stem
cell-based
approaches,
gene-editing
technologies
like
CRISPR.
Each
modality
has
demonstrated
substantial
potential
preclinical
models
is
now
being
cautiously
explored
early-stage
clinical
trials.
However,
translating
these
from
the
laboratory
practice
presents
unique
challenges:
safety
concerns,
delivery
precision,
complex
regulatory
requirements,
ethical
considerations,
high
costs
impede
widespread
adoption.
This
review
examines
current
landscape
rejuvenation,
highlighting
key
advancements,
risks,
strategies
needed
overcome
hurdles.
Next frontier.,
Journal Year:
2024,
Volume and Issue:
8(1), P. 199 - 199
Published: Nov. 28, 2024
Epigenetic
modifications
play
a
pivotal
role
in
cellular
differentiation
and
the
onset
of
complex
diseases
by
regulating
gene
expression
without
altering
underlying
DNA
sequence.
Mechanisms
such
as
methylation,
histone
modification,
chromatin
remodeling
orchestrate
transition
from
pluripotent
stem
cells
to
specialized
cell
types,
ensuring
tissue-specific
functionality.
This
research
delves
into
intricate
interplay
between
these
epigenetic
regulators
their
involvement
developmental
processes.
Moreover,
it
examines
how
aberrations
landscapes
contribute
pathogenesis
cancer,
neurodegenerative
disorders,
autoimmune
conditions.
By
employing
advanced
techniques
like
single-cell
epigenomics
CRISPR-based
editing,
this
study
aims
uncover
novel
biomarkers
therapeutic
targets.
The
findings
highlight
dynamic
reversible
nature
marks,
offering
promising
avenues
for
personalized
medicine.
Understanding
disease
development
is
essential
advancing
diagnostics,
therapeutics,
our
broader
understanding
human
biology.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13598 - 13598
Published: Dec. 19, 2024
Regenerative
medicine
and
tissue
engineering
aim
to
restore
or
replace
impaired
organs
tissues
using
cell
transplantation
supported
by
scaffolds.
Recently
scientists
are
focusing
on
developing
new
biomaterials
that
optimize
cellular
attachment,
migration,
proliferation,
differentiation.
Nanoparticles,
such
as
graphene
oxide
(GO),
have
emerged
versatile
materials
due
their
high
surface-to-volume
ratio
unique
chemical
properties,
electrical
conductivity
flexibility.
However,
GO
faces
challenges
cytotoxicity
at
concentrations,
a
negative
surface
charge,
potential
inflammatory
responses;
for
these
reasons,
variations
in
synthesis
been
studied.
A
derivative,
Graphene
Oxide-Polyethylenimine
(GO-PEI),
shows
controlled
porosity
structural
definition,
potentially
offering
better
support
growth.
Human
amniotic
fluid
stem
cells
(hAFSCs)
promising
candidate
regenerative
ability
differentiate
into
mesodermic
ectodermic
lineages,
non-immunogenic
nature,
ease
of
isolation.
This
study
investigates
the
effects
GO-PEI
hAFSCs,
adhesion,
metabolic
features.
Results
indicate
restores
proliferation
mitochondrial
activity
control
levels,
with
respect
appeared
less
biocompatible.
Both
also
influence
miRNA
cargo
hAFSC-derived
microvesicles,
influencing
cell-to-cell
communication.
International Journal of Clinical and Experimental Pathology,
Journal Year:
2024,
Volume and Issue:
17(12), P. 458 - 468
Published: Jan. 1, 2024
B-cell
specific
Moloney
MLV
insertion
site-1
(Bmi-1)
belongs
to
the
polycomb
group
(PcG)
gene
and
is
a
transcriptional
suppressor
maintain
appropriate
expression
patterns
during
development.
To
investigate
whether
Bmi-1
has
corrective
effect
on
bone
senescence
induced
in
Littermate
heterozygous
male
female
mice
(Bmi-1
Our
results
indicated
that
could
proportionally
rescued
suffering
from
aging
by
defects.
plays
an
anti-aging
through
multiple
aspects,
such
as
increasing
osteoblast
formation
decreascing
osteoclast
absorption,
stimulating
proliferation,
reducing
apoptosis,
inhibiting
reactive
oxygen
species
(ROS)
delaying
DNA
damage.
suggested
may
play
fundamental
important
role
correcting
BKO
mice.
At
same
time,
it
provide
theoretical
basis
for
clinical
application
of
bone.
