Clinical Neurology and Neurosurgery, Journal Year: 2024, Volume and Issue: 246, P. 108541 - 108541
Published: Sept. 10, 2024
Language: Английский
Trends in Immunology, Journal Year: 2024, Volume and Issue: 45(10), P. 799 - 813
Published: Sept. 21, 2024
Language: Английский
Citations
4
Medical Hypotheses, Journal Year: 2025, Volume and Issue: 196, P. 111582 - 111582
Published: Jan. 31, 2025
Language: Английский
Citations
0
Current Opinion in Neurology, Journal Year: 2025, Volume and Issue: unknown
Published: March 19, 2025
Purpose of review To summarize recent advancements in understanding multiple sclerosis (MS) pathophysiology, predicting disease course, and monitoring treatment responses using MRI. Recent findings Paramagnetic rim lesions (PRLs) are highly specific to MS clinically relevant. Detected from the earliest phases, PRLs aid distinguishing other conditions, improving diagnostic accuracy. Moreover, associated with more severe disability measures brain damage may predict progression. Similarly, slowly expanding (SELs) a course. Disease-modifying therapies have limited effectiveness reducing or SELs. Choroid plexus (CP) enlargement is structural clinical predicts evolution. Enlarged perivascular spaces (ePVS) suggest microangiopathic changes rather than direct MS-related inflammation. Glymphatic dysfunction, evaluated diffusion tensor image analysis along space, emerges early correlates disability, cognitive impairment, damage. Aging comorbidities exacerbate damage, complicating diagnosis treatment. Emerging technologies, such as brain-age paradigms, aim disentangle aging MS-specific neurodegeneration. Summary Advances MRI highlighted significance chronic inflammation glymphatic dysfunction contributors progression well interplay between aging, MS.
Language: Английский
Citations
0
Multiple Sclerosis Journal, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 6, 2024
The pathophysiology of multiple sclerosis (MS) remains poorly understood despite decades tremendous research efforts. Advances in neuroradiography coupled with availability unbiased approaches including spatial transcriptomics, proteomics, metabolomics, and lipidomics that are compatible brain fluid specimens from patients raise hope discovery novel disease drivers is on the horizon. Once thought to be little more than salty bathwater, our modern understanding cerebrospinal (CSF) suggests CSF as a compelling, critical regulator function health disease. Recent studies field have reinvigorated interest medium better understand MS deliver disease-modifying therapies. In turn, choroid plexus, an epithelial tissue located within each ventricle regulates forms key blood-CSF barrier, uniquely positioned orchestrate neuroinflammation associated MS. this perspective review, we will discuss what known about plexus conductor immune responses how it may propagate via CSF.
Language: Английский
Citations
2
Current Opinion in Neurology, Journal Year: 2024, Volume and Issue: 38(1), P. 87 - 95
Published: Dec. 4, 2024
Spaceflight-associated neuro-ocular syndrome (SANS) encompasses a unique constellation of findings in astronauts, including optic disc edema (ODE), globe flattening, chorioretinal folds, and hyperopic refractive shift. Although there are numerous SANS, the purpose this review is to describe novel, emerging concepts pathogenesis for ODE specifically SANS.
Language: Английский
Citations
1
Lymphatic Research and Biology, Journal Year: 2024, Volume and Issue: 22(1), P. 66 - 88
Published: Feb. 1, 2024
Language: Английский
Citations
0
Clinical Neurology and Neurosurgery, Journal Year: 2024, Volume and Issue: 246, P. 108541 - 108541
Published: Sept. 10, 2024
Language: Английский
Citations
0