Tackling exosome and nuclear receptor interaction: an emerging paradigm in the treatment of chronic diseases

Military Medical Research, Journal Year: 2024, Volume and Issue: 11(1)

Published: Sept. 26, 2024

Abstract Nuclear receptors (NRs) function as crucial transcription factors in orchestrating essential functions within the realms of development, host defense, and homeostasis body. NRs have garnered increased attention due to their potential therapeutic targets, with drugs directed at demonstrating significant efficacy impeding chronic disease progression. Consequently, these pharmacological agents hold promise for treatment management various diseases. Accumulating evidence emphasizes regulatory role exosome-derived microRNAs (miRNAs) inflammation, progression, therapy resistance, primarily by modulating factors, particularly NRs. By exploiting inflammatory pathways such protein kinase B (Akt)/mammalian target rapamycin (mTOR), nuclear factor kappa-B (NF-κB), signal transducer activator 3 (STAT3), Wnt/β-catenin signaling, exosomes play a pivotal panorama physiology, pathology. The internalization modulates initiates diverse autocrine or paracrine signaling cascades, influencing processes recipient cells survival, proliferation, differentiation, metabolism, cellular defense mechanisms. This comprehensive review meticulously examines involvement exosome-mediated NR regulation pathogenesis ailments, including atherosclerosis, cancer, diabetes, liver diseases, respiratory conditions. Additionally, it elucidates molecular intricacies communication between via NRs, leading immunomodulation. Furthermore, outlines implications exosome-modulated prophylaxis delineates current limitations, provides insights into future perspectives. also presents existing on components emergence resistance.

Language: Английский

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Dynamic interplay of nuclear receptors in tumor cell plasticity and drug resistance: Shifting gears in malignant transformations and applications in cancer therapeutics

Cancer and Metastasis Reviews, Journal Year: 2024, Volume and Issue: 43(1), P. 321 - 362

Published: March 1, 2024

Language: Английский

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Green synthesis, in silico modeling, and biological evaluation of N-substituted (Z)-5-arylidene imidazolidine/thiazolidine-2,4-dione/4-thione derivatives catalyzed by Bu SO₃H core–shell nanostructures

RSC Advances, Journal Year: 2024, Volume and Issue: 14(32), P. 22916 - 22938

Published: Jan. 1, 2024

The newly designed magnetic nanocatalyst Fe 3 O 4 @CPTMS@guanidine–BuSO H in a one-pot multicomponent reaction is reported to obtain N -substituted ( Z )-5-arylidene imidazolidine/thiazolidine-2,4-dione/4-thione as highly selective antiproliferation agent.

Language: Английский

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Restoring FXR expression as a novel treatment strategy in liver cancer and other liver disorders

Expert Opinion on Therapeutic Targets, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Liver cancer is a leading cause of cancer-associated mortality and often linked to preexisting liver conditions. Emerging research demonstrates FXR dysregulation, particularly its reduced expression, in the pathogenesis diseases, including inflammation, fibrosis, cholestatic disorders, metabolic cancer. Therefore, this review explores role agonists mitigating these This article summarizes FXR's involvement primarily emphasizing on hepatic neoplasms, examines potential restoring activity thereby preventing their progression The information presented drawn from existing preclinical clinical studies specific each disorder, sourced PubMed. It well established that expression downregulated contributing disease progression. Notably, have demonstrated therapeutic ameliorating hepatocellular carcinoma. We believe activating or with offers significant promise for treatment other modulation by agonists, combination agents, could lead more targeted treatments, improving efficacy while reducing side effects.

Language: Английский

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Nuclear receptors in ovarian cancer: changing paradigms in cancer therapeutics

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: July 15, 2024

Ovarian cancer (OVC) is one of the most common causes cancer-related deaths in women worldwide. Despite advancements detection and therapy, prognosis OVC remains poor due to late diagnosis lack effective therapeutic options at advanced stages. Therefore, a better understanding biology underlying essential for development strategies early targeted therapies. Nuclear receptors (NRs) are superfamily 48 transcription factors that, upon binding their specific ligand, play vital role regulating various cellular processes such as growth, development, metabolism, homeostasis. Accumulating evidence from several studies has shown that aberrant expression associated with multiple human diseases. Numerous NRs have significant effects cancers, including OVC. This review summarizes recent findings on OVC, well potential prognostic markers. Further, basic structure signaling mechanism also been discussed briefly. Moreover, this highlights molecular mechanisms chemoresistance chemosensitization. clinical trials targeting treatment discussed.

Language: Английский

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Synergistic enhancement: Exploring the potential of piperine in cancer therapeutics through chemosensitization and combination therapies

Life Sciences, Journal Year: 2024, Volume and Issue: 354, P. 122943 - 122943

Published: Aug. 6, 2024

Language: Английский

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