Macrophages in inflammatory skin diseases and skin tumors DOI Creative Commons
Sihan Liu, Jie Zhang, Ya‐Gang Zuo

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 5, 2024

Macrophages, as specialized, long-lasting phagocytic cells of the innate immune system, have garnered increasing attention due to their wide distribution and various functions. The skin, being largest organ in human body, presents an intriguing landscape for macrophage research, particularly regarding roles inflammatory skin diseases tumors. In this review, we compile latest research on macrophages conditions such atopic dermatitis, psoriasis, systemic sclerosis, lupus erythematosus, rosacea, bullous pemphigoid, melanoma cutaneous T-cell lymphoma. We aim contribute illustrating pathogenesis potential new therapies tumors from perspective macrophages.

Language: Английский

S100A8/A9 Promotes Dendritic Cell–Mediated Th17 Cell Response in Sjögren's Dry Eye Disease by Regulating the Acod1/STAT3 Pathway DOI Creative Commons
Yankai Wei, Mei Sun, Xinyu Zhang

et al.

Investigative Ophthalmology & Visual Science, Journal Year: 2025, Volume and Issue: 66(1), P. 35 - 35

Published: Jan. 14, 2025

Purpose: To investigate the role of S100A8/A9 in pathogenesis Sjögren's dry eye disease (SjDED) and explore its potential mechanism action. Methods: expression was determined by western blot quantitative real-time polymerase chain reaction (qRT-PCR). Tear secretion, corneal fluorescein staining, hematoxylin eosin staining were used to evaluate effect paquinimod, a inhibitor, on nonobese diabetic (NOD) mice. Immune cell infiltration percentage assessed immunofluorescence flow cytometry. Proinflammatory cytokine levels examined qRT-PCR or ELISA. The action analyzed using blot, immunofluorescence, chromatin immunoprecipitation. Results: upregulated peripheral blood mononuclear cells patients with SjDED lacrimal glands (LGs) upregulation correlated severity inflammatory LGs. Administration paquinimod ameliorated clinical histopathological phenotypes mice reduced proportion Th17 LGs, lymph nodes, spleens. Further experiments revealed that did not directly affect generation function but major histocompatibility complex Ⅱ (MHC Ⅱ) Th17-polarizing cytokines dendritic (DCs) augment response. Mechanistically, induced Acod1 thereby promoted activation nuclear translocation signal transducer activator transcription 3 (STAT3), resulting increased Il23a transcription. STAT3 reversed therapeutic Conclusions: activated Acod1/STAT3 pathway promote DC-driven responses SjDED. S100A8/A9/Acod1/STAT3 may represent promising target for

Language: Английский

Citations

1
The role of multiomics in revealing the mechanism of skin repair and regeneration DOI Creative Commons
Shaoyan Shi, Xuehai Ou,

JeffreyR. Long

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 17, 2025

Skin repair and regeneration are crucial processes in restoring the integrity of skin after injury, with significant implications for medical treatments plastic surgery. Multiomics, an integrated approach combining genomics, transcriptomics, proteomics, metabolomics, offers unprecedented insights into complex molecular cellular mechanisms involved healing. This review explores transformative role multiomics elucidating regeneration. While genomic studies identify genetic basis wound healing, transcriptomics proteomics uncover dynamic changes gene protein expression, metabolomics provides a snapshot metabolic alterations associated Integrative can also novel biomarkers therapeutic targets Despite technical biological challenges, future research holds great promise advancing personalized medicine improving healing strategies. Through interdisciplinary collaboration, has potential to revolutionize our understanding repair, paving way innovative surgery beyond.

Language: Английский

Citations

0
Nano-Azurin Peptide as an Inducer of Innate Immune Responses DOI
Nawal E. Al-Hazmi,

Hussam A. Althagafi,

Fahad A. Alharthi

et al.

Enzyme and Microbial Technology, Journal Year: 2025, Volume and Issue: unknown, P. 110675 - 110675

Published: May 1, 2025

Language: Английский

Citations

0
Alarming and Calming: dual functions of S100A9 on Mycoplasma gallisepticun infection in avian cells DOI
Yingjie Wang,

Mengyun Zou,

Jin Liu

et al.

Veterinary Microbiology, Journal Year: 2024, Volume and Issue: 296, P. 110175 - 110175

Published: July 15, 2024

Language: Английский

Citations

0
FASN contributes to the pathogenesis of lupus by promoting TLR-mediated activation of macrophages and dendritic cells DOI
Y Xiao,

Yangzhe Gao,

Yuxin Hu

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113136 - 113136

Published: Sept. 17, 2024

Language: Английский

Citations

0
Cryptotanshinone Alleviates Immunosuppression in Endometriosis by Targeting MDSCs through JAK2/STAT3 Pathway DOI

Linling Xie,

Yu Zhong,

Yi Chen

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 136, P. 156227 - 156227

Published: Nov. 14, 2024

Language: Английский

Citations

0
Macrophages in inflammatory skin diseases and skin tumors DOI Creative Commons
Sihan Liu, Jie Zhang, Ya‐Gang Zuo

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 5, 2024

Macrophages, as specialized, long-lasting phagocytic cells of the innate immune system, have garnered increasing attention due to their wide distribution and various functions. The skin, being largest organ in human body, presents an intriguing landscape for macrophage research, particularly regarding roles inflammatory skin diseases tumors. In this review, we compile latest research on macrophages conditions such atopic dermatitis, psoriasis, systemic sclerosis, lupus erythematosus, rosacea, bullous pemphigoid, melanoma cutaneous T-cell lymphoma. We aim contribute illustrating pathogenesis potential new therapies tumors from perspective macrophages.

Language: Английский

Citations

0