Vascular inflammation and biogenesis of lipid droplets; what is the link? DOI Creative Commons
Natalia Chorazy, Kamila Wojnar‐Lason, Magdalena Sternak

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1870(5), P. 167201 - 167201

Published: April 26, 2024

Endothelial lipid droplets (LDs) were previously understood to be harmful accumulations of lipids. However, a new perspective on endothelial LDs suggests that they are multifunctional organelles which protect the vasculature in response inflammatory insult or overload. Research summarised this review vascular pathophysiology associated with various diseases may linked altered dynamics LD formation and lipolysis. Thus, pharmacotherapy aimed at normalising number vasoprotective during inflammation post-prandial phase, as well other pathological conditions.

Language: Английский

Endothelial deletion of adipose triglyceride lipase protects against heart failure with preserved ejection fraction DOI Creative Commons
Juliane Schwanbeck,

Max Stahnke,

Anna Eberlein

et al.

JCI Insight, Journal Year: 2025, Volume and Issue: 10(5)

Published: March 9, 2025

Language: Английский

Citations

0
Sodium-glucose co-transporters (SGLT2) inhibitors prevent lipid droplets formation in vascular inflammation or lipid overload by SGLT2-independent mechanism DOI
Natalia Chorazy, Kamila Wojnar‐Lason, Anna M. Gdula

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 185, P. 117967 - 117967

Published: March 14, 2025

Language: Английский

Citations

0
Vascular inflammation and biogenesis of lipid droplets; what is the link? DOI Creative Commons
Natalia Chorazy, Kamila Wojnar‐Lason, Magdalena Sternak

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1870(5), P. 167201 - 167201

Published: April 26, 2024

Endothelial lipid droplets (LDs) were previously understood to be harmful accumulations of lipids. However, a new perspective on endothelial LDs suggests that they are multifunctional organelles which protect the vasculature in response inflammatory insult or overload. Research summarised this review vascular pathophysiology associated with various diseases may linked altered dynamics LD formation and lipolysis. Thus, pharmacotherapy aimed at normalising number vasoprotective during inflammation post-prandial phase, as well other pathological conditions.

Language: Английский

Citations

1