The roles of LncRNA CARMN in cancers: biomarker potential, therapeutic targeting, and immune response DOI Creative Commons
Huafeng Liu, Xuewen Liu, Yanjun Lu

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 18, 2024

Long non-coding RNAs (LncRNAs) are crucial regulators of gene expression and cellular processes, with significant implications for cancer research. This review focuses on the role LncRNA CARMN (Cardiac Arrest Regulated Myocyte Nuclear Protein) in various cancers. CARMN, originally identified its function cardiac tissues, has shown dysregulated several tumor types, including cervical, breast, colorectal, esophageal Its altered often correlates progression, metastasis, patient prognosis, suggesting potential as both a biomarker therapeutic target. In cervical cancer, CARMN's suppressor is highlighted by ability to inhibit cell proliferation, migration, invasion through interaction miR-92a-3p/BTG2 axis modulation Wnt/β-catenin signaling pathway. breast acts an enhancer RNA, affecting epithelial-mesenchymal transition metastasis regulating MMP2 via DHX9. The downregulation triple-negative associated enhanced sensitivity chemotherapy. colorectal regulated m6A methylation mutant p53, influencing growth miR-5683 FGF2. Lastly, genetic variations affect susceptibility, certain SNPs haplotypes either increased or decreased risk. Additionally, relationship between immune dynamics highlights surveillance therapy. Finally, we found that may regulate exhaustion microenvironment recruitment activation NK cells T cells, well modulating macrophage polarization. emphasizes diverse roles across different cancers diagnostic tool. Future research should address mechanistic details involvement validate clinical utility, explore combination existing treatments.

Language: Английский

Emerging Roles of Long Non‐Coding RNAs in Cardiovascular Diseases DOI Creative Commons

Xiangyue Kong,

Fengjuan Li, Yuan Wang

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(5)

Published: March 1, 2025

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Over past decade, studies have demonstrated that circulating long non-coding RNAs (lncRNAs)-recognised for their stability ease detection-serve as crucial regulators potential biomarkers in multiple diseases. LncRNAs regulate key processes, including endothelial function, vascular remodelling, myocardial hypertrophy, all which influence CVD progression. Additionally, lncRNAs display cell-, tissue-, disease-specific expression patterns, making them ideal therapeutic targets or tools. This review presents a comprehensive overview current understanding CVDs, examining mechanisms action recent research advances. It also addresses use diagnostic prognostic markers, well applications RNA therapeutics novel treatment strategies.

Language: Английский

Citations

0
SAMD4A inhibits abdominal aortic aneurysm development and VSMC phenotypic transformation through targeting KDM2B DOI Creative Commons
Qing Chen,

Shenrong Liu,

Haobin Zhou

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Abdominal aortic aneurysm (AAA) is a fatal vascular disease without effective drug treatments. Pathological smooth muscle cell (VSMC) phenotypic transformation the underlying cause of AAA. However, mechanism has not been fully elucidated. We aimed to determine whether RNA binding protein SAMD4A suppresses VSMC phenotype and inhibits AAA formation. Single-cell sequencing (scRNA-seq) was conducted reveal heterogeneity RNA-binding dysregulation during A pancreatic elastase (PPE)-induced mouse model generated confirm function in vivo. RNA-seq combined with immunoprecipitation (RIP) chromatin (ChIP)-qPCR used for mechanistic exploration. identified 3 subtypes, demonstrated their from contractile inflammatory-like VSMCs expression increased significantly reduced AAAs. The results functional experiments revealed that VSMC-specific knockout exacerbated PPE-induced formation, whereas knock-in attenuated regulated contraction by KDM2B. Further vivo studies overexpression KDM2B abolished protective effect ChIP-qPCR suppressed transcription markers promoters reducing H3K4me3 H3K36me2 levels. development targeting This work highlights potential as new therapeutic option prevent

Language: Английский

Citations

0
Role of long noncoding RNAs in diabetes-associated peripheral arterial disease DOI Creative Commons
Alonso Tapia, Xuejing Liu, Naseeb Kaur Malhi

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: July 24, 2024

Abstract Diabetes mellitus (DM) is a metabolic disease that heightens the risks of many vascular complications, including peripheral arterial (PAD). Various types cells, but not limited to endothelial cells (ECs), smooth muscle (VSMCs), and macrophages (MΦs), play crucial roles in pathogenesis DM-PAD. Long non-coding RNAs (lncRNAs) are epigenetic regulators important cellular function, their dysregulation DM can contribute PAD. This review focuses on developing field lncRNAs emerging linking We studies investigating role processes contributing DM-PAD, those ECs, VSMCs, MΦ. By examining intricate molecular landscape governed by these relevant cell types, we hope shed light EC dysfunction, inflammatory responses, remodeling Additionally, provide an overview research approach methodologies, from identifying disease-relevant characterizing functions context also discuss potential leveraging diagnosis therapeutics for Collectively, this provides summary lncRNA-regulated DM-PAD highlights translational lncRNA biology tackle increasingly prevalent complex disease. Graphical

Language: Английский

Citations

1
Exploring the Spectrum of Long Non-Coding RNA CARMN in Physiological and Pathological Contexts DOI Creative Commons
Hui Li,

Chuannan Sun,

Bin Luo

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 954 - 954

Published: Aug. 6, 2024

Cardiac mesoderm enhancer-associated non-coding RNA (CARMN), an evolutionarily conserved long (lncRNA), serves as the host gene for miR143/145 cluster. It plays a crucial role in cardiovascular cell differentiation and maintenance of vascular smooth muscle (VSMC) homeostasis, which are vital normal physiological processes. Specifically, CARMN is associated with pathological progression diseases such atherosclerosis, abdominal aortic aneurysm, chronic heart failure. Moreover, it acts tumor suppressor various cancers, including hepatocellular carcinoma, bladder cancer, breast highlighting its potential beneficial biomarker therapeutic target. This review provides detailed examination roles CARMN, evolutionary conservation, expression patterns, regulatory mechanisms. also outlines significant implications diagnosis, prognosis, treatment these diseases, underscoring need further translational research to exploit clinical potential.

Language: Английский

Citations

1
Intrinsic GATA4 expression sensitizes the aortic root to dilation in a Loeys–Dietz syndrome mouse model DOI Creative Commons
Emily E. Bramel,

Wendy A. Espinoza Camejo,

Tyler J. Creamer

et al.

Nature Cardiovascular Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Loeys–Dietz syndrome (LDS) is a connective tissue disorder caused by mutations that decrease transforming growth factor-β signaling. LDS-causing increase the risk of aneurysm throughout arterial tree, yet aortic root site heightened susceptibility. Here we investigate heterogeneity vascular smooth muscle cells (VSMCs) in aorta Tgfbr1M318R/+ LDS mice single-cell transcriptomics to identify molecular determinants this vulnerability. Reduced expression components extracellular matrix–receptor apparatus and upregulation stress inflammatory pathways were observed all VSMCs. However, regardless genotype, subset Gata4-expressing VSMCs predominantly located intrinsically displayed less differentiated, proinflammatory profile. A similar population was also identified among human RNA sequencing dataset. Postnatal VSMC-specific Gata4 deletion reduced dilation mice, suggesting factor sensitizes effects impaired Bramel et al. GATA4+ enriched mouse more susceptible Loeys–Dietz-syndrome-causing demonstrate postnatal reduces model syndrome.

Language: Английский

Citations

0
New insights into the pharmacological inhibition of SRF activity: Key inhibitory targets and mechanisms DOI

Daniel M. Wong,

Hongyu Qiu

Vascular Pharmacology, Journal Year: 2024, Volume and Issue: 157, P. 107443 - 107443

Published: Nov. 23, 2024

Language: Английский

Citations

0
The roles of LncRNA CARMN in cancers: biomarker potential, therapeutic targeting, and immune response DOI Creative Commons
Huafeng Liu, Xuewen Liu, Yanjun Lu

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 18, 2024

Long non-coding RNAs (LncRNAs) are crucial regulators of gene expression and cellular processes, with significant implications for cancer research. This review focuses on the role LncRNA CARMN (Cardiac Arrest Regulated Myocyte Nuclear Protein) in various cancers. CARMN, originally identified its function cardiac tissues, has shown dysregulated several tumor types, including cervical, breast, colorectal, esophageal Its altered often correlates progression, metastasis, patient prognosis, suggesting potential as both a biomarker therapeutic target. In cervical cancer, CARMN's suppressor is highlighted by ability to inhibit cell proliferation, migration, invasion through interaction miR-92a-3p/BTG2 axis modulation Wnt/β-catenin signaling pathway. breast acts an enhancer RNA, affecting epithelial-mesenchymal transition metastasis regulating MMP2 via DHX9. The downregulation triple-negative associated enhanced sensitivity chemotherapy. colorectal regulated m6A methylation mutant p53, influencing growth miR-5683 FGF2. Lastly, genetic variations affect susceptibility, certain SNPs haplotypes either increased or decreased risk. Additionally, relationship between immune dynamics highlights surveillance therapy. Finally, we found that may regulate exhaustion microenvironment recruitment activation NK cells T cells, well modulating macrophage polarization. emphasizes diverse roles across different cancers diagnostic tool. Future research should address mechanistic details involvement validate clinical utility, explore combination existing treatments.

Language: Английский

Citations

0