Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 18, 2024
Ferroptosis
is
a
new
form
of
cell
death
that
differs
from
traditional
forms
death.
It
ferroptosis-dependent
lipid
peroxidation
Colorectal
cancer(CRC)
the
most
common
tumor
in
gastrointestinal
tract
with
long
occultation
period
and
poor
five-year
prognosis.
Exploring
effective
systemic
treatments
for
CRC
remains
great
challenge
worldwide.
Numerous
studies
have
demonstrated
ferroptosis
can
participate
biological
malignant
process
various
tumor,
including
CRC,
so
understanding
role
regulatory
mechanisms
plays
crucial
treatment
CRC.
In
this
paper,
we
reviews
associated
factors
their
interactions
immune
cells
microenvironment.
addition,
targeting
has
emerged
as
an
encouraging
strategy
treatment.
Finally,
to
inform
subsequent
research
clinical
diagnosis
treatment,
review
therapeutic
approaches
radiotherapy,
immunotherapy,
herbal
therapy
ferroptosis.
Frontiers in Genetics,
Journal Year:
2024,
Volume and Issue:
15
Published: July 26, 2024
Mitochondrial
dysfunction
has
been
shown
to
play
a
critical
role
in
cancer
biology.
However,
its
involvement
intrahepatic
cholangiocarcinoma
(iCCA)
remains
significantly
understudied.
