The Features of the Genetically-Encoded Biosensor to PIP3 Influence on Insulin Signaling in MSCs DOI

A. P. Fedorovsky,

Maxim Karagyaur, Nikita Voloshin

et al.

Biochemistry (Moscow) Supplement Series B Biomedical Chemistry, Journal Year: 2024, Volume and Issue: 18(S1), P. S91 - S98

Published: Dec. 1, 2024

Language: Английский

Cellular mechanical memory: a potential tool for mesenchymal stem cell-based therapy DOI Creative Commons
Sanjay Kumar Kureel,

Rosario Maroto,

Kristen C. Davis

et al.

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 31, 2025

Abstract Recent studies have shown that mechanical properties such as extracellular matrix stiffness, fluid flow, weight loading, compression, and stretching can affect cellular functions. Some examples of cell responses to could be the migration cancer cells from rigid soft surfaces or differentiation fibroblasts into myofibroblasts. Cellular changes modify insertion proteins in (ECM), causing an increase tissue stiffness with functional consequences. In general, physical factors any kind phenotype culture conditions vivo tissues. Cells sense stimuli by applying force restructuring their shape functions response resistance stimuli. Furthermore, triggers develop a “memory” for altering plasticity adaptation. This phenomenon is called memory (CMM), singular feature mesenchymal stem (MSCs). Controlled targeting CMM may resolve scarcity viable needed based therapy (CBT) implement concerning research, fibrosis, senescence. review focusses on mesodermal lineage, MSCs, chondrocytes, role potential target CBT.

Language: Английский

Citations

1
Visualization of H3K9me3 in Embryoid Bodies Using Genetically Encoded Fluorescent Sensor MPP8-Green DOI

А. И. Степанов,

Elena B. Zhigmitova, Э. Б. Дашинимаев

et al.

Russian Journal of Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 51(1), P. 229 - 234

Published: Feb. 1, 2025

Language: Английский

Citations

0
Live-Cell Visualization of Histone Modification Using Bimolecular Complementation DOI

A. I. Stepanov,

Lidia V. Putlyaeva, Alexandra A. Shuvaeva

et al.

Russian Journal of Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 51(1), P. 320 - 329

Published: Feb. 1, 2025

Language: Английский

Citations

0
Genetically encoded epigenetic sensors for visualization of H3K9me3, H3K9ac and H3K4me1 histone modifications in living cells DOI

Afanasii I. Stepanov,

Lidia V. Putlyaeva,

Zlata Besedovskaya

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 733, P. 150715 - 150715

Published: Sept. 20, 2024

Language: Английский

Citations

0
The Features of the Genetically-Encoded Biosensor to PIP3 Influence on Insulin Signaling in MSCs DOI

A. P. Fedorovsky,

Maxim Karagyaur, Nikita Voloshin

et al.

Biochemistry (Moscow) Supplement Series B Biomedical Chemistry, Journal Year: 2024, Volume and Issue: 18(S1), P. S91 - S98

Published: Dec. 1, 2024

Language: Английский

Citations

0