Improving Biomedical Science Literacy and Patient-Directed Knowledge of Tuberculosis (TB): A Cross-Sectional Infodemiology Study Examining Readability of Patient-Facing TB Information DOI Creative Commons

Caoimhe Shannon,

B. Cherie Millar, John E. Moore

et al.

British Journal of Biomedical Science, Journal Year: 2024, Volume and Issue: 81

Published: Oct. 22, 2024

Background Tuberculosis (TB) continues be the leading cause of death globally due to an infectious agent. There is a paucity data describing readability patient-facing TB information for service users. The aim this study was calculate multiple global sources. Methods Information on tuberculosis (n = 150 sources) included nine categories, Patient-facing information: WHO publications 17), International governments 19), Hospitals 10), Non-government organisations (NGOs)/charities 20), Cochrane Plain Language Summaries 20); LabTestsOnlineUK 4) and Scientific-facing Clinical trials abstracts Scientific 20). Readability calculated using Readable software, defined by (i) Flesch Reading Ease (FRE), (ii) Flesch-Kincaid Grade Level (FKGL), (iii) Gunning Fog Index (iv) SMOG two text metrics [words/sentence, syllables/word]. Results Mean values FRE FKGL were 35.6 ± 1.6 (standard error mean (SEM)) (US Target ≥60; UK ≥90) 12.3 0.3 ≤8; ≤6), respectively, with words per sentence syllables word 17.2 1.8, respectively. had similar scores their matching scientific abstract (p 0.15). yielded score 51.5 1.2, 10.2 0.5 metric 16.7 2.3 1.6, word, In descending order, from international governments, hospitals most readable (FRE 57.9, 54.1 51.5, respectively), whereas difficult read (13.0 30.2, respectively). Conclusion analysed poor readability. Effective communication biomedical science concepts relating vital users enhance health literacy tuberculosis, thereby promoting better clinical outcomes. Biomedical scientists are important custodians user populations, including other healthcare professionals within multidisciplinary (MDT) team patient When preparing information, should checked modified in real time employing calculators, align targets.

Language: Английский

The Clinical and Laboratory Landscape of COVID-19 During the Initial Period of the Pandemic and at the Beginning of the Omicron Era DOI Creative Commons
Yulia Desheva, Tamara Shvedova, Olga Kopteva

et al.

Viruses, Journal Year: 2025, Volume and Issue: 17(4), P. 481 - 481

Published: March 27, 2025

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underwent significant mutations, resulting in the Omicron variant. Methods: In this study, we analyzed blood samples from 98 patients with disease 19 (COVID-19) hospitalized during initial SARS-CoV-2 wave and onset of 2021. High-resolution melting (HRM) analysis PCR products was used to analyze RNA extracted clinical collected July November 2021 infected SARS-CoV-2. Results: HRM revealed a characteristic deletion N protein virus isolated 2021, associated Elevated levels inflammatory markers interleukin-6 (IL-6) were observed both waves COVID-19. Complement IgG IgM antibodies detected more often second wave. An increase hemagglutinin-inhibiting (HI) against influenza viruses paired specimens moderate severe COVID-19 outbreaks. Conclusions: Patients admitted showed rise markers, suggesting that triggers responses. The rapid formation may indicate faster immune response. Seasonal flu negatively impact course infections.

Language: Английский

Citations

0
Expanded Spectrum and Increased Incidence of Adverse Events Linked to COVID-19 Genetic Vaccines: New Concepts on Prophylactic Immuno-Gene Therapy, Iatrogenic Orphan Disease, and Platform-Inherent Challenges DOI Creative Commons
János Szebeni

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 450 - 450

Published: March 31, 2025

The mRNA- and DNA-based “genetic” COVID-19 vaccines can induce a broad range of adverse events (AEs), with statistics showing significant variation depending on the timing data analysis methods used. Focusing only lipid nanoparticle-enclosed mRNA (mRNA-LNP) vaccines, this review traces evolution statistical conclusions prevalence AEs incidents associated these from initial underestimation atypical, severe toxicities to recent claims suggesting possible contribution vaccinations excess deaths observed in many countries over past few years. Among hundreds different listed Pfizer’s pharmacovigilance survey, present categorizes main symptoms according organ systems, nearly all them being affected. Using US Vaccine Adverse Event Reporting System global vaccination dataset, comparison incidence rates induced by genetic versus flu revealed an average 26-fold increase use vaccines. difference is especially pronounced case ‘Brighton-listed’ AEs, which are also post-COVID conditions. these, increases relative given as x-fold rises, were 1152x, 455x, 226x, 218x, 162x, 152x, 131x for myocarditis, thrombosis, death, myocardial infarction, tachycardia, dyspnea, hypertension, respectively. delineates concept that be regarded prophylactic immuno-gene therapies chronic disabling might categorized iatrogenic orphan diseases. It examines unique vaccine characteristics could causally related abnormal immune responses potentially lead complications. These new insights may contribute improving safety platform technology assessing risk/benefit balance various products.

Language: Английский

Citations

0
Proteomic Profiling of Endothelial Cell Secretomes After Exposure to Calciprotein Particles Reveals Downregulation of Basement Membrane Assembly and Increased Release of Soluble CD59 DOI Open Access
Alexander D. Stepanov, Д. К. Шишкова, Victoria Markova

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11382 - 11382

Published: Oct. 23, 2024

Calciprotein particles (CPPs) are essential circulating scavengers of excessive Ca

Language: Английский

Citations

3
Improving Biomedical Science Literacy and Patient-Directed Knowledge of Tuberculosis (TB): A Cross-Sectional Infodemiology Study Examining Readability of Patient-Facing TB Information DOI Creative Commons

Caoimhe Shannon,

B. Cherie Millar, John E. Moore

et al.

British Journal of Biomedical Science, Journal Year: 2024, Volume and Issue: 81

Published: Oct. 22, 2024

Background Tuberculosis (TB) continues be the leading cause of death globally due to an infectious agent. There is a paucity data describing readability patient-facing TB information for service users. The aim this study was calculate multiple global sources. Methods Information on tuberculosis (n = 150 sources) included nine categories, Patient-facing information: WHO publications 17), International governments 19), Hospitals 10), Non-government organisations (NGOs)/charities 20), Cochrane Plain Language Summaries 20); LabTestsOnlineUK 4) and Scientific-facing Clinical trials abstracts Scientific 20). Readability calculated using Readable software, defined by (i) Flesch Reading Ease (FRE), (ii) Flesch-Kincaid Grade Level (FKGL), (iii) Gunning Fog Index (iv) SMOG two text metrics [words/sentence, syllables/word]. Results Mean values FRE FKGL were 35.6 ± 1.6 (standard error mean (SEM)) (US Target ≥60; UK ≥90) 12.3 0.3 ≤8; ≤6), respectively, with words per sentence syllables word 17.2 1.8, respectively. had similar scores their matching scientific abstract (p 0.15). yielded score 51.5 1.2, 10.2 0.5 metric 16.7 2.3 1.6, word, In descending order, from international governments, hospitals most readable (FRE 57.9, 54.1 51.5, respectively), whereas difficult read (13.0 30.2, respectively). Conclusion analysed poor readability. Effective communication biomedical science concepts relating vital users enhance health literacy tuberculosis, thereby promoting better clinical outcomes. Biomedical scientists are important custodians user populations, including other healthcare professionals within multidisciplinary (MDT) team patient When preparing information, should checked modified in real time employing calculators, align targets.

Language: Английский

Citations

0