Synthesis and Characterization of New Schiff Base Derivatives from Quinazolinone Moiety and Studying Their Properties as Potential Corrosion Inhibitors DOI
Mohammed G. A. Al-Khuzaie,

Shahad F. Ali,

Saja Sabbood

et al.

Protection of Metals and Physical Chemistry of Surfaces, Journal Year: 2024, Volume and Issue: 60(6), P. 1173 - 1182

Published: Dec. 1, 2024

Language: Английский

Exploring Quinazoline as a Scaffold for Developing Novel Therapeutics in Alzheimer’s Disease DOI Creative Commons
Qais Abualassal, Zead Abudayeh,

Ala’ Yahya Sirhan

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 555 - 555

Published: Jan. 26, 2025

Quinazoline, a privileged scaffold in medicinal chemistry, offers promising potential the synthesis of anti-Alzheimer’s disease (AD) drugs. This heterocyclic compound, characterized by its fused benzene and pyrimidine rings, enables design multifunctional agents targeting AD pathology. The drug-like aspects pharmaceutical features quinazoline derivatives have to give rise various therapeutic is progressive neurodegenerative condition marked memory decline, cognitive deterioration, language disorders. Given complexity multifaceted nature, there pressing need discover multi-target drugs effectively address this debilitating disorder. A comprehensive literature review has demonstrated that exhibit wide range for AD. These compounds function as inhibitors cholinesterases, β-amyloid aggregation, oxidative stress, tau protein, among other protective effects. Here, we highlight most significant recent research on quinazoline-based anti-AD agents, aiming support development discovery novel treatments

Language: Английский

Citations

0
Recent advances on anticancer activity of benzodiazine heterocycles through kinase inhibition DOI Creative Commons
Mohamed S. Nafie, Sherif Ashraf Fahmy,

Shaima H. Kahwash

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(7), P. 5597 - 5638

Published: Jan. 1, 2025

This is an updated review for the anticancer activity of benzodiazine heterocyclic derivatives through kinase inhibition.

Language: Английский

Citations

0
The Aza-Diels-Alder Reaction Between Cyclic Imine and Aza-ortho-quinone Methide Precursor to Access Polycyclic-fused Tetrahydroquinazoline DOI
Xiaoke Zhang, Lu He, Xuan Zhang

et al.

Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134665 - 134665

Published: April 1, 2025

Language: Английский

Citations

0
Synthesis, antimicrobial, cytotoxic and in silico studies of pyridine-quinazolin-4(3H)-one hybrids DOI

Ibrahim A. Bala,

Abdelsattar M. Omar, Yosra A. Muhammad

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142275 - 142275

Published: April 1, 2025

Language: Английский

Citations

0
Synthesis and Characterization of New Schiff Base Derivatives from Quinazolinone Moiety and Studying Their Properties as Potential Corrosion Inhibitors DOI
Mohammed G. A. Al-Khuzaie,

Shahad F. Ali,

Saja Sabbood

et al.

Protection of Metals and Physical Chemistry of Surfaces, Journal Year: 2024, Volume and Issue: 60(6), P. 1173 - 1182

Published: Dec. 1, 2024

Language: Английский

Citations

0