Thermoradiotherapy optimization strategies accounting for hyperthermia delivery uncertainties DOI Creative Commons
Timoteo D. Herrera, Jakob Ödén,

Andrea Lorenzo Polo

et al.

International Journal of Radiation Oncology*Biology*Physics, Journal Year: 2024, Volume and Issue: 120(5), P. 1435 - 1447

Published: July 15, 2024

IntroductionThe combined effect of hyperthermia and radiotherapy can be quantified by an enhanced equivalent radiation dose (EQDRT). Uncertainties in treatment planning adjustments during impact achieved EQDRT. We developed compared strategies for EQDRT optimization plans, focusing on robustness against common adjustments.MethodsUsing Plan2Heat, we computed pre-planning plans adjustment scenarios three cervical cancer patients. imported these into RayStation 12A with four different strategies: (1) Conventional prescribing 46 Gy to the target volume (PTV), (2) Nominal using scenario, targeting uniform 58 gross tumor (GTV), keeping organs at risk (OAR) doses as plan (1), (3) Robust optimization, but adding adjusted (4) Library Plans (four plans), strategy criteria optimizing one scenario per plan. calculated each distributions scenarios, evaluating combination GTV coverage homogeneity objectives.ResultsEQDRT95% increased from 49.9-50.9 56.1-57.4 improving ∼10%. Strategy demonstrated best overall robustness, 62% all objectives within tolerance. had higher percentage tolerance than (68% vs 54%), lower uniformity (44% 71%). showed similar EQDRT95% scenario. D0.1% OARs was (2-4) up ∼6 Gy.ConclusionsEQDRT enhances levels conventional optimization. Better is improves reduces homogeneity. A library ensures when dealing scenarios.

Language: Английский

Thermoradiotherapy optimization strategies accounting for hyperthermia delivery uncertainties DOI Creative Commons
Timoteo D. Herrera, Jakob Ödén,

Andrea Lorenzo Polo

et al.

International Journal of Radiation Oncology*Biology*Physics, Journal Year: 2024, Volume and Issue: 120(5), P. 1435 - 1447

Published: July 15, 2024

IntroductionThe combined effect of hyperthermia and radiotherapy can be quantified by an enhanced equivalent radiation dose (EQDRT). Uncertainties in treatment planning adjustments during impact achieved EQDRT. We developed compared strategies for EQDRT optimization plans, focusing on robustness against common adjustments.MethodsUsing Plan2Heat, we computed pre-planning plans adjustment scenarios three cervical cancer patients. imported these into RayStation 12A with four different strategies: (1) Conventional prescribing 46 Gy to the target volume (PTV), (2) Nominal using scenario, targeting uniform 58 gross tumor (GTV), keeping organs at risk (OAR) doses as plan (1), (3) Robust optimization, but adding adjusted (4) Library Plans (four plans), strategy criteria optimizing one scenario per plan. calculated each distributions scenarios, evaluating combination GTV coverage homogeneity objectives.ResultsEQDRT95% increased from 49.9-50.9 56.1-57.4 improving ∼10%. Strategy demonstrated best overall robustness, 62% all objectives within tolerance. had higher percentage tolerance than (68% vs 54%), lower uniformity (44% 71%). showed similar EQDRT95% scenario. D0.1% OARs was (2-4) up ∼6 Gy.ConclusionsEQDRT enhances levels conventional optimization. Better is improves reduces homogeneity. A library ensures when dealing scenarios.

Language: Английский

Citations

0