Long‐term cardiac outcomes in breast cancer patients treated with helical tomotherapy: Evaluating the applicability of 3D‐based dose constraints for intensity modulated radiation therapy DOI
Pierre Loap,

Abdelkarim Uakkas,

Jihane Bouziane

et al.

International Journal of Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: May 23, 2025

Abstract Adjuvant breast radiotherapy has been associated with cardiac toxicity due to older 2D and 3D techniques, a linear relationship between mean heart dose (MHD) ischemic events. Cardiac distribution differs modern techniques like intensity‐modulated (IMRT), potentially affecting this relationship. This study evaluates long‐term in cancer patients treated tomotherapy reassess 3D‐derived constraints. Breast at Institut Curie from August 2010 December 2015 were included. Patients had undergone breast‐conserving surgery or mastectomy, some receiving chemotherapy trastuzumab. Tomotherapy was used for anatomically challenging cases. The primary endpoint correlated MHD; secondary endpoints overall disease‐specific survival. Statistical analyses included logistic regression Cox models. Among 179 patients, the median MHD 7.04 Gy, 95.6% having an above 5 Gy. Sixty‐six cardiovascular risk factors, 28.5% obese. Over follow‐up of 9.1 years, eight (4.5%) experienced events—all pre‐existing risks obesity. No significant correlation found major coronary events ( p = 0.607) failure 0.800). mortality absent, 10‐year survival 88.0% 94.3%, respectively. rare driven by factors. MHD‐toxicity observed may not apply IMRT, leading overestimated risks. Long‐term studies are needed refine IMRT

Language: Английский

Long‐term cardiac outcomes in breast cancer patients treated with helical tomotherapy: Evaluating the applicability of 3D‐based dose constraints for intensity modulated radiation therapy DOI
Pierre Loap,

Abdelkarim Uakkas,

Jihane Bouziane

et al.

International Journal of Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: May 23, 2025

Abstract Adjuvant breast radiotherapy has been associated with cardiac toxicity due to older 2D and 3D techniques, a linear relationship between mean heart dose (MHD) ischemic events. Cardiac distribution differs modern techniques like intensity‐modulated (IMRT), potentially affecting this relationship. This study evaluates long‐term in cancer patients treated tomotherapy reassess 3D‐derived constraints. Breast at Institut Curie from August 2010 December 2015 were included. Patients had undergone breast‐conserving surgery or mastectomy, some receiving chemotherapy trastuzumab. Tomotherapy was used for anatomically challenging cases. The primary endpoint correlated MHD; secondary endpoints overall disease‐specific survival. Statistical analyses included logistic regression Cox models. Among 179 patients, the median MHD 7.04 Gy, 95.6% having an above 5 Gy. Sixty‐six cardiovascular risk factors, 28.5% obese. Over follow‐up of 9.1 years, eight (4.5%) experienced events—all pre‐existing risks obesity. No significant correlation found major coronary events ( p = 0.607) failure 0.800). mortality absent, 10‐year survival 88.0% 94.3%, respectively. rare driven by factors. MHD‐toxicity observed may not apply IMRT, leading overestimated risks. Long‐term studies are needed refine IMRT

Language: Английский

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