American Journal of Cardiovascular Drugs, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 20, 2024
Language: Английский
Heart Rhythm, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
BackgroundFriedreich's ataxia (FA) is a rare inherited neuromuscular disorder, where most patients die from lethal cardiomyopathy and arrhythmias. Mechanisms leading to arrhythmic events in FA are poorly understood.ObjectiveThis study aims examine cardiac electrical signal propagation mouse model of with severe evaluate effects omaveloxolone (OMAV), the first FDA-approved therapy.MethodsCardiac-specific MCK-Cre frataxin knockout (FXN-cKO) mice were used mimic cardiomyopathy. In vivo surface ECG recordings, western blotting, qPCR, histochemistry performed.ResultsCharacteristics like long QT syndrome, interatrial block, ST-segment abnormalities identified FXN-cKO mice. exhibited sexual dimorphism structural integrity. Untreated males showed increased ventricular intervals, while females delayed atrial propagation. OMAV no significant therapeutic effect on average time intervals but improved chamber-specific waveforms when aggregated frequency distributions analyzed. The J-wave was absent male reappeared treatment. Poincaré plots revealed disparate idiopathic arrhythmias multi-clustering individual high incidence males. treatment reduced single cluster; however, ANS dysfunction still remained.ConclusionOur disturbances irregularities heart rhythm dysfunction. function by stabilizing early repolarization reducing This work stresses sex-specific interpretations alternative mathematical approaches for drug testing models.Graphical abstract
Language: Английский
Citations
1
Molecules, Journal Year: 2023, Volume and Issue: 28(16), P. 6078 - 6078
Published: Aug. 15, 2023
Many studies have suggested that the oxidized form of nicotinamide adenine dinucleotide (NAD+) is involved in an extensive spectrum human pathologies, including neurodegenerative disorders, cardiomyopathy, obesity, and diabetes. Further, healthy aging longevity appear to be closely related NAD+ its metabolites, riboside (NR) mononucleotide (NMN). As a dietary supplement, NR appears well tolerated, having better pharmacodynamics greater potency. Unfortunately, reactive molecule, often unstable during manufacturing, transport, storage. Recently, work prebiotic chemistry discovered borate considerably more stable than itself. However, immediately upon consumption, dissociates from lost body through dilution binding other species, notably carbohydrates such as fructose glucose. The left behind expected behave pharmacologically ways identical This review provides comprehensive summary (through Q1 2023) literature makes case for consumption supplement. It then summarizes challenges delivering quality consumers using standard synthesis, manufacture, shipping, storage approaches. concludes by outlining advantages these processes.
Language: Английский
Citations
15
Journal of Molecular Medicine, Journal Year: 2023, Volume and Issue: 101(11), P. 1379 - 1396
Published: Sept. 14, 2023
Language: Английский
Citations
13
Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: 68(8)
Published: March 29, 2024
Abstract Cardiovascular diseases (CVDs) are a leading cause of global mortality and novel approaches for prevention management needed. The human gastrointestinal tract hosts diverse microbiota that is crucial in maintaining metabolic homeostasis. formulation effective probiotics, alone or combination, has been under discussion due to their impact on cardiovascular diseases. Probiotics have shown health positively. An imbalance the presence Firmicutes Bacteroidetes linked progression CVDs bile acid cholesterol metabolism. probiotics primarily help reduction plasma low‐density lipoprotein levels attenuation proinflammatory markers. These beneficial microorganisms contribute lowering produce essential short‐chain fatty acids. lipid‐regulating probiotic strains quite significant. However, only few tested potential efficacy, ambiguity exists regarding strain dosages, interactions with confounding factors, adverse effects. Hence, more comprehensive studies randomized trials needed understand mechanisms ensure health. This review assesses evidence highlights roles strain‐specific CVDs.
Language: Английский
Citations
4
Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 221, P. 235 - 244
Published: May 28, 2024
Language: Английский
Citations
2
Experimental Biology and Medicine, Journal Year: 2023, Volume and Issue: 248(16), P. 1383 - 1392
Published: Aug. 1, 2023
Increased vulnerability to physiologic stressors, termed frailty, is a common occurrence in patients with chronic heart failure (CHF). However, the definite biomarkers assess frailty CHF are not known. Here, we assessed phenotype and its potential association (HF) markers patients. We categorized controls ( n = 59) 80), participants, into robust, pre-frail, frail based on cardiovascular health study (CHS) index. The plasma levels of HF markers, including tumorigenicity 2 (s-ST2), galectin-3, heart-type fatty acid binding protein (H-FABP), were measured correlated cardiac function. s-ST2, H-FABP profoundly elevated Conversely, index scores significantly lower ischemic non-ischemic versus controls. Of only was positively r 0.07, P 0.02) score Collectively, these observations suggest that circulating may serve as biomarker
Language: Английский
Citations
2
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: May 27, 2024
Abstract Dysregulated autophagy/mitophagy is one of the major causes cardiac injury in ischemic conditions. Glycogen synthase kinase-3alpha (GSK-3α) has been shown to play a crucial role pathophysiology diseases. However, precise GSK-3α mitophagy remains unknown. Herein, we investigated by employing AC16 human cardiomyocytes under condition acute hypoxia. We observed that gain-of-GSK-3α function profoundly induced post-hypoxia. Moreover, overexpression led increased ROS generation and mitochondrial dysfunction cardiomyocytes, accompanied enhanced displayed mt-mKeima intensity Mechanistically, identified promotes through upregulation BNIP3, caused GSK-3α-mediated increase expression HIF-1α FOXO3a physical interaction with BNIP3 and, inhibited PINK1 Parkin recruitment mitochondria was specifically Taken together, novel mechanism cardiomyocytes. regulates -mediated facilitate following An between suggests membrane where it enhances stressed independent PINK1/Parkin.
Language: Английский
Citations
0
Polish Journal of Cardio-Thoracic Surgery, Journal Year: 2024, Volume and Issue: 21(2), P. 86 - 95
Published: Jan. 1, 2024
AMA Kibria F, Das S, Arefin M. The role of nicotinamide adenine dinucleotide salvage enzymes in cardioprotection. Kardiochirurgia i Torakochirurgia Polska/Polish Journal Thoracic and Cardiovascular Surgery. 2024;21(2):86-95. doi:10.5114/kitp.2024.141145. APA Kibria, F., Das, S., & Arefin, (2024). Surgery, 21(2), 86-95. https://doi.org/10.5114/kitp.2024.141145 Chicago Fazle, Sudip Kumar Md Sahidul Arefin. 2024. "The cardioprotection". Surgery 21 (2): Harvard pp.86-95. MLA Fazle et al. cardioprotection." vol. 21, no. 2, 2024, pp. Vancouver
Language: Английский
Citations
0
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1870(8), P. 167487 - 167487
Published: Aug. 30, 2024
Language: Английский
Citations
0
American Journal of Cardiovascular Drugs, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 20, 2024
Language: Английский
Citations
0