S1-Leitlinie Long-/Post-COVID

Pneumologie, Journal Year: 2022, Volume and Issue: 76(12), P. 855 - 907

Published: Dec. 1, 2022

The German Society of Pneumology initiated 2021 the AWMF S1 guideline Long COVID/Post-COVID. In a broad interdisciplinary approach, this was designed based on current state knowledge.The clinical recommendations describe COVID/Post-COVID symptoms, diagnostic approaches, and therapies.In addition to general consensus introduction, subject-specific approach taken summarize has an explicit practical claim will be developed adapted by author team increase in knowledge.Die Deutsche Gesellschaft für Pneumologie hat die S1-Leitlinie Long-/Post-COVID initiiert. einem breiten interdisziplinären Ansatz wurde diese basierend auf dem aktuellen Wissensstand gestaltet.Die klinische Empfehlung beschreibt Long- bzw. Post-COVID-Symptome, diagnostische Ansätze und Therapien.Neben der allgemeinen konsentierten Einführung ein fachspezifischer Zugang gewählt, den zusammenfasst.Die Leitlinie einen explizit praktischen Anspruch wird Wissenszugewinn vom Autorenteam weiterentwickelt adaptiert.

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Post-COVID syndrome

Deutsches Ärzteblatt international, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 10, 2023

As defined by the WHO, term post-COVID syndrome (PCS) embraces a group of symptoms that can occur following acute phase SARS-CoV-2 infection and as consequence thereof. PCS is found mainly in adults, less frequently children adolescents. It develop both patients who initially had only mild or none at all those severe course coronavirus disease 2019 (COVID-19).The data presented here were derived from systematic literature review.PCS occurs up to 15% unvaccinated adults infected with SARS-CoV-2. The prevalence has decreased most recent pandemic lower after vaccination. pathogenesis not yet been fully elucidated. Virustriggered inflammation, autoimmunity, endothelial damage (to blood vessels), persistence virus are thought be causative. Owing broad viral tropism, different organs involved vary. To date, there hardly any evidence-based recommendations for definitive diagnosis its treatment.The gaps our knowledge mean better documentation necessary compile on which early detection, diagnosis, treatment based. ensure best possible care PCS, regional centers networks embracing existing structures healthcare system sectors providers should set structured algorithms established. Given sometimes serious consequences affected, it seems advisable keep number infections low protective measures tailored prevailing situation.

Language: Английский

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Long COVID in pediatrics—epidemiology, diagnosis, and management

European Journal of Pediatrics, Journal Year: 2024, Volume and Issue: 183(4), P. 1543 - 1553

Published: Jan. 27, 2024

Abstract This review summarizes current knowledge on post-acute sequelae of COVID-19 (PASC) and post-COVID-19 condition (PCC) in children adolescents. A literature was performed to synthesize information from clinical studies, expert opinions, guidelines. PASC also termed Long COVID — at any age comprise a plethora unspecific symptoms present later than 4 weeks after confirmed or probable infection with severe respiratory syndrome corona virus type 2 (SARS-CoV-2), without another medical explanation. PCC adolescents defined by the WHO as occurring within 3 months acute coronavirus disease 2019 (COVID-19), lasting least months, limiting daily activities. Pediatric mostly manifest mild courses majority cases remit few months. However, can last for more 1 year may result significant disability. Frequent include fatigue, exertion intolerance, anxiety. Some patients postural tachycardia (PoTS), small number fulfill criteria myalgic encephalomyelitis/chronic fatigue (ME/CFS). To date, no diagnostic marker has been established, differential diagnostics remains challenging. Therapeutic approaches appropriate self-management well palliation non-pharmaceutical pharmaceutical strategies. Conclusion : pediatrics heterogenous severity duration. stepped, interdisciplinary, individualized approach is essential management. Current health care structures have be adapted, research extended meet psychosocial needs young people similar conditions. What Known: • Post-acute (COVID-19) lead activity limitation reduced quality life. belongs large group syndromes (PAIS). Specific biomarkers causal treatment options are not yet available. New: In February 2023, case definition post provided World Health Organization (WHO), indicating duration Interdisciplinary collaborations necessary established worldwide offer harmonized, multimodal diagnosis management PASC/PCC

Language: Английский

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S1 guidelines for the management of postviral conditions using the example of post-COVID-19

Wiener klinische Wochenschrift, Journal Year: 2023, Volume and Issue: 135(S4), P. 525 - 598

Published: July 1, 2023

Zusammenfassung Die vorliegende Leitlinie S1 ist die Aktualisierung und Weiterentwicklung der Long COVID: Differenzialdiagnostik Behandlungsstrategien. Sie fasst den Stand Kenntnis zu postviralen Zuständen anhand des Beispiels Long/Post COVID zum Zeitpunkt Redaktionsschlusses zusammen. Aufgrund starken Dynamik Wissensentwicklung versteht sie sich als „living guideline“. Der Schwerpunkt liegt auf praktischen Anwendbarkeit Ebene hausärztlichen Primärversorgung, geeignete Stelle für Erstzutritt primäre Betreuung Behandlung verstanden wird. gibt Empfehlungen Versorgungsgang, häufigsten Symptome, in Folge einer Infektion wie mit SARS-CoV‑2 auftreten können, therapeutischen Optionen, Patient:innenführung -betreuung sowie zur Wiedereingliederung Alltag Rehabilitation. Entsprechend Krankheitsbildes einem interdisziplinären interprofessionellen Prozess entstanden Schnittstellen Kooperationsmöglichkeiten.

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Post-COVID-19 Syndrome: Retinal Microcirculation as a Potential Marker for Chronic Fatigue

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(22), P. 13683 - 13683

Published: Nov. 8, 2022

Post-COVID-19 syndrome (PCS) is characterized by persisting sequelae after infection with severe acute respiratory coronavirus 2 (SARS-CoV-2). PCS can affect patients all COVID-19 disease severities. As previous studies have revealed impaired blood flow as a provoking factor triggering PCS, it was the aim of present study to investigate potential association between self-reported chronic fatigue and retinal microcirculation in potentially indicating an objective biomarker. A prospective performed, including 201 subjects: 173 28 controls. Retinal visualized OCT angiography (OCT-A) quantified using Erlangen-Angio-Tool macula peripapillary vessel density (VD). Chronic (CF) assessed according variables Bell’s score, age gender. VDs superficial vascular plexus (SVP), intermediate capillary (ICP) deep (DCP) were analyzed, considering repetitions (12 times). Seropositivity for autoantibodies targeting G protein-coupled receptors (GPCR-AAbs) determined established cardiomyocyte bioassay. Taking account repetitions, mixed model performed detect possible differences least square means different groups included analysis. An effect relation VD observed controls (p < 0.0001). Gender analysis showed that women lower levels SVP compared male = 0.0015). The significantly ICP 0.0001 (CI: 0.32; 1)). Moreover, patients, significant difference those without CF respect 0.0033 −4.5; −0.92)). age, gender representing subjective marker CF. Consequently, might serve biomarker subjectively reported PCS.

Language: Английский

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High Prevalence of Alternative Diagnoses in Children and Adolescents with Suspected Long COVID—A Single Center Cohort Study

Viruses, Journal Year: 2023, Volume and Issue: 15(2), P. 579 - 579

Published: Feb. 20, 2023

Long COVID (LC) is a diagnosis that requires exclusion of alternative somatic and mental diseases. The aim this study was to examine the prevalence differential diagnoses in suspected pediatric LC patients assess whether adult symptom clusters are applicable patients.Pediatric presentations at Pediatric Infectious Diseases Department University Hospital Essen (Germany) were assessed retrospectively. correlation initial symptoms final (LC versus other diseases or unclarified) assessed. sensitivity, specificity, negative positive predictive values calculated.Of 110 patients, 32 (29%) suffered from LC, 52 (47%) diagnosed with somatic/mental diseases, 26 (23%) remained unclarified. Combined neurological respiratory displayed sensitivity 0.97 (95% CI 0.91-1.00) value (0.92-1.00) for LC.The high. range underlying wide, including chronic potentially life-threatening conditions. Neurological may help identify unlikely be suffering LC.

Language: Английский

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Post-COVID bei jungen Menschen

Nervenheilkunde, Journal Year: 2025, Volume and Issue: 44(01/02), P. 16 - 23

Published: Feb. 1, 2025

Zusammenfassung Nach aktuellen Schätzungen leiden ca. 5–10 % aller symptomatisch Infizierten nach Abklingen der akuten COVID-19-Erkrankung unter länger anhaltenden gesundheitlichen Beeinträchtigungen. Psychische Symptome und kognitive Beeinträchtigungen zählen zu häufigen Symptomen von Long- insbesondere Post-COVID. Während sich für Erwachsene zahlreiche Publikationen Post-COVID finden, ist die Datenlage Kinder Adoleszente verhältnismäßig dünn uneinheitlich. Angesichts weniger dramatischer Akutverläufe in dieser Gruppe Assoziation Schwere des Akutverlaufs zur Wahrscheinlichkeit Auftretens war nicht mit einem bedeutsamen Auftreten gerechnet worden. Insbesondere hinsichtlich ihrer psychischen kognitiven Entwicklungen sind aber besonders durch störende Einflüsse gefährdet. Diese Gefährdungen können Coronavirus-Erkrankung direkt ausgehen. Auch Maßnahmen Eindämmung Pandemie haben wesentlich Entwicklung Kindern Adoleszenten eingegriffen. Für das Verständnis bei Therapieansätzen Kenntnis vorliegenden Forschungsergebnisse relevant. Dieser Artikel fasst daher aktuelle Wissen um Long-COVID psychischer kognitiver zusammen.

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Chronisches Fatigue Syndrom ME/CFS und Komorbiditäten

Springer Reference Medizin, Journal Year: 2025, Volume and Issue: unknown, P. 553 - 558

Published: Jan. 1, 2025

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Long Covid / Post-COVID-19-Syndrom bei Kindern und Jugendlichen

Pädiatrie, Journal Year: 2022, Volume and Issue: 34(3), P. 20 - 25

Published: June 1, 2022

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The CSHQ-DE Questionnaire Uncovers Relevant Sleep Disorders in Children and Adolescents with Long COVID

Children, Journal Year: 2022, Volume and Issue: 9(9), P. 1419 - 1419

Published: Sept. 19, 2022

Acute SARS-CoV-2 infections in children and adolescents are usually mild. However, they can suffer from ongoing symptoms, generally referred to as long COVID. Sleep disorders one of the most frequent complaints COVID although precise data missing. We assessed sleep behavior who presented at our outpatient clinic between January 2021 May 2022 with Children's Habits Questionnaire (CSHQ-DE). compared three different time points: pre-COVID-19; post-COVID-19 initial presentation; re-presentation. Data 45 patients were analyzed. Of those, 64% female median age was 10 years (range: 0-18 years). Asymptomatic or mild COVID-19 disease experienced 89% patients; 11% moderate disease. The presentation occurred a 20.4 weeks (6 weeks-14 months) after infection. CSHQ-DE score increased significantly pre-COVID-19 (45.82 ± 8.7 points) (49.40 8.3 points; p ≤ 0.01). then normalized re-presentation (46.98 7.8; = 0.1). greatest changes seen subscale "daytime sleepiness". Our showed that often disturbances. For adolescents, these decreased over without any further medical intervention aside basic consultation.

Language: Английский

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