Current Diabetes Reports, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 2, 2024
Language: Английский
Atherosclerosis, Journal Year: 2024, Volume and Issue: 394, P. 117545 - 117545
Published: April 17, 2024
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease, characterized by raised blood glucose levels and impaired lipid metabolism resulting from insulin resistance relative deficiency. In diabetes, the peculiar plasma lipoprotein phenotype, consisting in higher of apolipoprotein B-containing lipoproteins, hypertriglyceridemia, low HDL cholesterol, elevated number small, dense LDL, increased non-HDL results an synthesis clearance triglyceride rich lipoproteins. This condition accelerates development atherosclerotic cardiovascular disease (ASCVD), most common cause death T2DM patients. Here we review alteration structure, functions, distribution circulating lipoproteins pathophysiological mechanisms that induce these modifications T2DM. The analyzes influence diabetes-associated imbalances throughout entire process plaque formation, to potential destabilization. Addressing different mechanisms, suggest improved approaches for assessing risk adverse events clinical strategies reduce cardiometabolic diseases.
Language: Английский
Citations
18
Journal of the American College of Cardiology, Journal Year: 2024, Volume and Issue: 84(14), P. 1328 - 1338
Published: Sept. 23, 2024
Language: Английский
Citations
12
Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Abstract Background and Aims Adequate lipid control has emerged as a key factor in the prevention management of chronic kidney disease (CKD). Remnant cholesterol (RC), lipoprotein with an established association cardiovascular risk, been investigated context CKD. Given conflicting results from recent studies, we performed this meta‐analysis to summarize existing evidence on between RC Methods Medline, Cochrane Library Scopus were searched until 16 September 2024. Double‐independent study selection, data extraction quality assessment performed. Evidence was pooled using random‐effects meta‐analyses. We set primary end‐point interest Results Twelve studies (4 139 674 participants) included. Participants values highest quantile had significantly greater odds CKD compared those lowest (Odds Ratio [OR] = 1.46, 95% confidence interval [CI] 1.26–1.68). In sensitivity analysis confined subjects type 2 diabetes (T2D), higher also exhibited increased (OR CI 1.20–1.78). A significant inverse observed estimated glomerular filtration rate (Mean Difference [MD] −1.43 mL/min/1.73 m for each 1 mmol/L increase RC, [−2.67, −0.19]). Additionally, individuals T2D‐related 24% risk progression end‐stage renal standard deviation (Hazard [HR] 1.24, 1.04–1.47). Conclusions is directly associated Beyond traditional markers, emphasis should be placed levels or at
Language: Английский
Citations
1
Pharmacological Research, Journal Year: 2025, Volume and Issue: 214, P. 107694 - 107694
Published: March 10, 2025
Language: Английский
Citations
1
Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2023, Volume and Issue: 27(2), P. 125 - 135
Published: Nov. 21, 2023
Purpose of review Atherosclerotic cardiovascular disease (ASCVD) is the leading cause death despite development effective treatments. Recently, elevated remnant cholesterol and low-grade inflammation have emerged as factors explaining part residual ASCVD risk. Interestingly, coexistence both high can further increase risk ASCVD. The aim this to describe role inflammation, separately combined, in Recent findings Results from recently published studies, including observational genetic Mendelian randomization support a causal relationship between on primary secondary prevention settings. In addition, current evidence studies suggests that increases Summary suggest combined with may confer particular for Attention dual threat necessary, research field warranted. effect cholesterol-lowering drugs anti-inflammatory alone remains be elucidated. Video abstract http://links.lww.com/COCN/A20
Language: Английский
Citations
15
Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)
Published: Jan. 19, 2024
Abstract Background Numerous studies have affirmed a robust correlation between residual cholesterol (RC) and the occurrence of cardiovascular disease (CVD). However, current body literature fails to adequately address link alterations in RC CVD. Existing focused mainly on individual values. Hence, primary objective this study is elucidate association cumulative (Cum-RC) morbidity Methods The changes were categorized into high-level fast-growth group (Class 1) low-level slow-growth 2) by K-means cluster analysis. To investigate relationship combined exposure multiple lipids CVD risk, weighted quantile sum (WQS) regression analysis was employed. This involved calculation weights for total (TC), low-density lipoprotein (LDL), high-density (HDL), which used effectively RC. Results Among cohort 5,372 research participants, considerable proportion 45.94% consisted males, with median age 58. In three years follow-up, 669 participants (12.45%) had Logistic revealed that Class 2 individuals significantly reduced risk developing compared 1. probability having increased 13% every 1-unit increase Cum-RC according continuous variables. restricted cubic spline (RCS) showed linearly related ( P nonlinearity = 0.679). WQS results nonsignificant trend toward an index incidence but overall positive trend, greatest contribution from TC (weight 0.652), followed LDL 0.348). Conclusion positively strongly suggesting addition focusing traditional lipid markers, early intervention patients may further reduce
Language: Английский
Citations
5
Diabetes Research and Clinical Practice, Journal Year: 2024, Volume and Issue: 210, P. 111639 - 111639
Published: March 26, 2024
Language: Английский
Citations
5
Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)
Published: May 25, 2024
Remnant cholesterol (RC) has been known as an important factor for the assessment of metabolic syndrome (Mets) risk. However, correlation between RC and hyperuricemia (HUA) in type 2 diabetes mellitus (T2DM) remains unclear. This study aims to explore HUA patients with T2DM.
Language: Английский
Citations
5
Arteriosclerosis Thrombosis and Vascular Biology, Journal Year: 2024, Volume and Issue: 44(10), P. 2244 - 2251
Published: Aug. 15, 2024
BACKGROUND: Recent observational and Mendelian randomization analyses have reported significant effects of VLDL-C (very-low density lipoprotein cholesterol) on risk that is independent ApoB (apolipoprotein B). We aim to determine the association with new onset cardiovascular events in UK Biobank Framingham Heart Study cohorts. METHODS: included 294 289 participants a median age 56 years, 42% men, 2865 (median age, 53 years; 47% men). The residual resulting from regressing expresses portion not explained by ApoB, while VLDL-C. Cox proportional hazards models for atherosclerotic disease incidence were created ApoB. Models analyzed without high-density cholesterol (HDL-C). Furthermore, we investigated after accounting HDL-C RESULTS: In Biobank, was highly correlated (r=0.70; P <0.001) but weakly negatively (r=−0.11; <0.001). significantly associated new-onset (hazard ratio [HR], 1.08 1.05, respectively; After adjusting HDL-C, remained similar magnitude (HR, 1.10; <0.001), whereas effect size reduced 1.02; =0.029). (after VLDL-C) robust 0.86; <0.0001), HDL-C) modest All results consistent cohort. CONCLUSIONS: When adjusted no longer clinically meaningful. Our discordance analysis suggests adjustment cannot be ignored.
Language: Английский
Citations
5
European Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 54(8)
Published: April 13, 2024
The burden of cardiovascular disease is particularly high among individuals with diabetes, even when LDL cholesterol normal or within the therapeutic target. Despite this, accumulates in their arteries, part, due to persistent atherogenic dyslipidaemia characterized by elevated triglycerides, remnant cholesterol, smaller particles and reduced HDL cholesterol. causal link between atherosclerosis T2DM complex, our contention that a deeper understanding lipoprotein composition functionality, vehicle delivers artery, will provide insight for improving hidden risk diabetes. This narrative review covers three levels complexity characterization: 1-the information provided routine clinical biochemistry, 2-advanced nuclear magnetic resonance (NMR)-based profiling 3-the identification minor components physical properties lipoproteins can help explain arterial accumulation LDLc levels, which typically case T2DM. document highlights importance incorporating these layers lipoprotein-related into population-based studies on ASCVD Such an attempt should inevitably run parallel biotechnological solutions allow large-scale determination sets methodologically diverse parameters.
Language: Английский
Citations
4