Light-eye-body axis: exploring the network from retinal illumination to systemic regulation DOI Creative Commons
Yi Zeng, Rong Rong,

Mengling You

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 15(4), P. 1496 - 1523

Published: Dec. 31, 2024

The human body is an intricate system, where diverse and complex signaling among different organs sustains physiological activities. eye, as a primary organ for information acquisition, not only plays crucial role in visual perception but also, increasing evidence suggests, exerts broad influence on the entire through circuits upon receiving light signals which called non-image-forming vision. However, extent mechanisms of light's impact eyes remain insufficiently explored. There also dearth comprehensive reviews elucidating interplay between light, systemic connections to body. Herein, we propose concept light-eye-body axis systematically encapsulate extensive effects received by retina We reviewed visual-neural structure basis axis, summarized mechanism regulate whole current research status challenges within pathological processes involved axis. Future should aim expand explore its deeper mechanisms. Understanding investigating will contribute improving lighting conditions optimize health guide establishment phototherapy standards clinical practice.

Language: Английский

The role of melatonin and circadian rhythms in the pathogenesis of diabetic retinopathy: a systematic review DOI Creative Commons
Mallika Prem Senthil,

Eilish Devlin,

A. Hassani

et al.

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2025, Volume and Issue: 19(2), P. 103202 - 103202

Published: Feb. 1, 2025

Language: Английский

Citations

1
Insufficient Plasma Melatonin and Its Association With Neuropsychiatric Impairments in Patients With T2DM DOI Creative Commons
Shuai He, Yue Yu,

Peng-quan Chen

et al.

Journal of Diabetes Research, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Purpose: Type 2 diabetes mellitus (T2DM) is associated with multiple neuropsychiatric impairments, including cognitive dysfunction, and melatonin (MLT) plays a crucial role in maintaining normal functions. This study aimed at investigating the change plasma MLT levels its association impairments T2DM patients. Methods: One hundred twenty‐six patients were recruited, their demographics clinical data collected. Apart from glycated hemoglobin (HbA1c) other routine metabolic indicators, concentrations of MLT, C‐reactive protein (CRP), Interleukin 6 (IL‐6), soluble myeloid triggered receptor 1 (sTREM 1), 2) measured. Moreover, executive function depressive tendency evaluated via Behavior Rating Inventory Executive Function‐Adult Version (BRIEF‐A) Epidemiological Research Center Depression Scale (CES‐D), respectively. Result: Compared low HbA1c group, high group presented lower but higher inflammatory biomarker levels, together scores BRIEF‐A CES‐D scales. results Pearson correlation test showed that negatively correlated scores, as well indications, indicating may mediate neuroinflammation impairments. Furthermore, ROC curve indicated have predictive effect on impairment status Conclusion: decreased status, might be developed therapeutic agent indicator for T2DM‐associated depression status.

Language: Английский

Citations

3
Sleep Disturbances in Type 1 Diabetes and Mitigating Cardiovascular Risk DOI Creative Commons
Ghada Abu Irsheed, Pamela Martyn‐Nemeth, Kelly Glazer Baron

et al.

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: 109(12), P. 3011 - 3026

Published: Aug. 6, 2024

Abstract Cardiovascular disease (CVD) is a major cause of morbidity and mortality in persons with type 1 diabetes (T1D). Despite control known cardiovascular (CV) risk factors better glycemic management, T1D still face heightened CVD risk, suggesting additional contributing factors. Sleep has recently been recognized as CV factor; however; the role sleep specifically population only started to emerge. Extensive evidence suggests that often encounter disturbances. This review aims comprehensively explore relationship between disturbances T1D, proposed possible mediators including control, which studied more extensively, less such blood pressure, lipid metabolism, weight management. Stress self-care behaviors likely also play CVD. The regarding interventions context mitigating these shown early, small-scale studies. assessments should be part standard care T1D. Further research focus on understanding impact mechanistic pathways developing T1D-specific reduce burden this population.

Language: Английский

Citations

2
Association between rest-activity rhythm and diabetic retinopathy among US middle-age and older diabetic adults DOI Creative Commons
Zhijie Wang, Mengai Wu, Haidong Li

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 16, 2024

Background The disruption of circadian rhythm has been reported to aggravate the progression diabetic retinopathy (DR). Rest-activity (RAR) is a widely used method for measuring individual time influencing behavior. In this study, we sought explore potential association between RAR and risk DR. Methods Diabetic participants aged over 40 from 2011-2014 National Health Nutrition Examination Survey (NHANES) were enrolled. Data wearable device ActiGraph GT3X was generate metrics, including interdaily stability (IS), intradaily variability (IV), most active 10-hour period (M10), least 5-hour (L5), Relative amplitude (RA). Weighted multivariable logistic regression analysis restricted cubic spline conducted examine metrics DR risk. Sensitivity also robustness findings. An unsupervised K-means clustering identify patterns in IV M10. Results A total 1,096 enrolled, with prevalence 20.53%. mean age 62.3 years, 49.57% being male. After adjusting covariates, positively associated (β: 3.527, 95%CI: 1.371-9.073). Compared lowest quintile IV, highest had 136% higher odds contrast, M10 negatively 0.902, 0.828-0.982), showing 48.8% lower Restricted confirmed that these associations linear. Meanwhile, sensitivity robustness. identified three distinct clusters, Cluster C (high-IV, low-M10) significantly comparing (low-IV, high-M10). Conclusion more fragmented peak activity level might be an increased These findings indicate maintaining rhythmic sleep-activity behavior mitigate development Further research necessary establish causality understand underlying mechanisms, focus on whether interventions designed enhance daily increase diurnal can effectively

Language: Английский

Citations

0
Light-eye-body axis: exploring the network from retinal illumination to systemic regulation DOI Creative Commons
Yi Zeng, Rong Rong,

Mengling You

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 15(4), P. 1496 - 1523

Published: Dec. 31, 2024

The human body is an intricate system, where diverse and complex signaling among different organs sustains physiological activities. eye, as a primary organ for information acquisition, not only plays crucial role in visual perception but also, increasing evidence suggests, exerts broad influence on the entire through circuits upon receiving light signals which called non-image-forming vision. However, extent mechanisms of light's impact eyes remain insufficiently explored. There also dearth comprehensive reviews elucidating interplay between light, systemic connections to body. Herein, we propose concept light-eye-body axis systematically encapsulate extensive effects received by retina We reviewed visual-neural structure basis axis, summarized mechanism regulate whole current research status challenges within pathological processes involved axis. Future should aim expand explore its deeper mechanisms. Understanding investigating will contribute improving lighting conditions optimize health guide establishment phototherapy standards clinical practice.

Language: Английский

Citations

0