The association between the ZJU index and bone mineral density (BMD) among patients with type 2 diabetes mellitus

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Background Previous studies have suggested that type 2 diabetes mellitus (T2DM) is associated with poor bone health, including osteoporosis (OP) and osteopenia. The ZJU index, a novel calculation integrates fasting plasma glucose (FPG), body mass index (BMI), triglyceride (TG), alanine aminotransferase (ALT) to aspartate (AST) ratio, strongly glucolipid metabolism insulin resistance (IR). In this study, we explored the association of mineral density (BMD) OP/osteopenia, investigated predictive effect on OP/osteopenia in patients T2DM. Methods This cross-sectional study included 496 T2DM aged > 50 years. clinical data were collected BMD femoral neck (FN), left hip (LH), lumbar spine (LS) measured. between BMDs levels was by adjusting for covariates utilizing multiple linear regression analyses. Multivariable logistic constructed identify independent factors OP osteopenia, receiver operating characteristic (ROC) curves used display diagnostic performance according area under ROC curve (AUC). Results osteopenia showed significantly higher than those normal (39.387 ± 3.558, 38.112 2.552 vs 35.192 2.600, p < 0.001). Spearman’s correlation analysis negatively correlated FN (r = -0.39, 0.001), LH -0.35, LS -0.32, indicated negative (β -0.006, 0.009), -0.155, 0.011) after adjusted covariates. Meanwhile, results revealed contributing factor risk individuals years (OR 1.446, 95% CI: 1.087 ~ 1.923, 0.011; OR 1.878, 1.218 3.715, 0.039, respectively). provided AUC value 0.695 0.716 T2DM, respectively. Conclusions A high an increasing OP. expected be potential detecting decreased middle-aged elderly patients. Early intervention increased may further reduce incidence OP, addition focusing biomarker practice.

Language: Английский

Liver function linked to bone health: A bibliometric of the liver-bone axis

World Journal of Hepatology, Journal Year: 2025, Volume and Issue: 17(2)

Published: Feb. 20, 2025

BACKGROUND The liver exerts profound influence on skeletal health, while osseous tissues reciprocally modulate hepatic function. This bidirectional metabolic axis between these two organ systems plays a pivotal role in both physiological homeostasis and pathological states. AIM To investigate analyze the literatures liver-bone using bibliometrics. METHODS A comprehensive literature search pertaining to was conducted Science Citation Index Expanded within Web of Core Collection. Subsequently, visualization bibliometric analyses were performed utilizing VOSviewer (version 1.6.20), Citespace 6.2.R4), R programming language. RESULTS analysis encompasses 855 publications, comprising 694 articles 161 reviews, authored by 4988 researchers from 425 institutions across 61 countries. United States China emerge as leading nations terms publication volume. University California system stands out most influential institution research. Guanabens N is identified prolific author this field. annual increase publications related underscores its growing prominence research focus. study highlights key areas investigation, including osteoporosis, bone metabolism, non-alcoholic fatty disease, insulin-like growth factor-1, which represent current prospective hot topics domain. CONCLUSION investigation employs methodologies conduct systematic spanning 2001 2024. exponential over past decades significance synthesizing outcomes Through rigorous statistical analyses, we delineate fundamental contributions field providing strategic direction for emerging scholars. Furthermore, illuminate trajectories identify promising future investigative directions. Investigation enhances our comprehension inter-organ communication networks. Conceptualizing organs an integrated provides insights into pathophysiological mechanisms disease management strategies. paradigm not only facilitates development sophisticated diagnostic modalities but also catalyzes discovery novel therapeutic agents targeting mechanistic pathways, thereby advancing capacity diagnose treat disorders.

Language: Английский

GCKR Polymorphisms Increase the Risks of Low Bone Mineral Density in Young and Non‐Obese Patients With MASLD and Hyperuricemia

The Kaohsiung Journal of Medical Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

ABSTRACT Metabolic‐associated steatotic liver disease (MASLD) encompasses common comorbidities including low bone mineral density (BMD) and hyperuricemia (HU), yet relevant genetic analyses are limited. This study aimed to investigate the effects of risk single nucleotide polymorphisms (SNPs) on occurrence BMD in patients with MASLD HU, particularly focusing relatively young or non‐obese populations. We conducted a cross‐sectional utilizing data from Taiwan Biobank, screening total 150,709 participants who were prospectively enrolled over period 13 years. The SNPs for identified. Genotype HU its general population evaluated, further MASLD, subgroup A 20,496 eligible analysis, 7526 MASLD. Several Furthermore, carrying PNPLA3‐rs738409 C_C, PNPLA3‐rs2896019 T_T, GCKR‐rs780094 GCKR‐rs1260326 T_T genotypes exhibited an increased comorbidity HU. Trend analysis revealed that T alleles associated individuals comorbid among In young, significantly increase BMD. Given presence these ostensibly low‐risk groups, heightened awareness close follow‐up recommended.

Language: Английский