Recent advancements in the synthesis of fused thienopyridines and their therapeutic applications
Ranjay Shaw,
No information about this author
Ritu Tewari,
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Monika Yadav
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et al.
European Journal of Medicinal Chemistry Reports,
Journal Year:
2024,
Volume and Issue:
12, P. 100185 - 100185
Published: July 2, 2024
Fused
thienopyridines
represent
a
class
of
heterocyclic
molecules
that
have
garnered
increasing
attention
due
to
their
unique
structural
features
and
versatile
chemical
properties.
This
review
systematically
examines
the
latest
synthetic
methodologies
employed
in
preparing
fused
thienopyridine
derivatives,
emphasizing
innovative
approaches
contribute
diversity.
Moreover,
discussion
extends
broad
spectrum
therapeutic
applications
offer,
encompassing
utility
different
diseases.
The
explores
pharmacological
activities
biological
properties
thienopyridines,
shedding
light
on
role
drug
discovery
development.
By
offering
comprehensive
overview
recent
advancements
both
synthesis
this
will
serve
as
valuable
resource
for
researchers
practitioners
navigating
evolving
landscape
medicinal
chemistry.
Language: Английский
Combinations of approved oral nucleoside analogues confer potent suppression of alphaviruses in vitro and in vivo
Antiviral Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 106186 - 106186
Published: May 1, 2025
Language: Английский
In silico molecular screening of bioactive natural compounds of rosemary essential oil and extracts for pharmacological potentials against rhinoviruses
Dhananjay Singh,
No information about this author
Nishu Mittal,
No information about this author
Pooja Mittal
No information about this author
et al.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: July 29, 2024
Rhinoviruses
(RVs)
cause
upper
respiratory
tract
infections
and
pneumonia
in
children
adults.
These
non-enveloped
viruses
contain
viral
coats
of
four
capsid
proteins:
VP1,
VP2,
VP3,
VP4.
The
canyon
on
VP1
used
cell
surface
receptor
ICAM-1
as
the
site
attachment
for
internalization
viruses.
To
date,
there
has
been
no
drug
or
vaccine
available
against
RVs.
In
this
study,
bioactive
natural
compounds
rosemary
(Salvia
rosmarinus
L.),
which
are
known
their
pharmacological
potential,
were
considered
to
target
protein.
A
total
30
taken
ligands
proteins.
PkCSM
tool
was
detect
adherence
Lipinski's
rule
five
ADMET
properties
selected
ligands.
Further,
CB-Dock
molecular
docking
studies
between
protein
Based
profiling
results,
phenethyl
amine
(4
methoxy
benzyl)
lead
compound.
comparative
study
performed
compound
two
antiviral
drugs,
Placonaril
Nitazoxanide,
investigate
higher
potential
over
synthetic
drugs.
also
targets
but
failed
clinical
trials
while
Nitazoxanide
examined
rhinoviruses.
It
discovered
from
that
exhibited
less
toxicity
comparison
other
tested
drugs
More
research
is
needed
determine
its
make
it
a
good
medication
Language: Английский
β-enaminoester derivatives exhibit promising in vitro and in silico antiviral potential against Mayaro virus
Archives of Microbiology,
Journal Year:
2024,
Volume and Issue:
206(10)
Published: Sept. 18, 2024
Language: Английский
Thienopyridine Analogues
Advances in bioinformatics and biomedical engineering book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 271 - 316
Published: Nov. 27, 2024
Thienopyridine
derivatives
are
important
sulfur-containing
compounds
with
a
unique
structure.
There
six
different
analogues
that
have
shown
various
biological
effects.
These
widely
used
in
medicinal
chemistry
and
some
been
approved
by
the
FDA
for
use
as
drugs.
The
most
well-known
applications
of
thienopyridine-based
drugs
treating
cardiovascular
central
nervous
system
(CNS)
diseases.
also
anti-inflammatory,
anti-infective,
antiviral,
antiproliferative,
antimicrobial,
antitumor
properties.
positive
effects
on
characteristics
they
part
of,
such
solubility,
lipophilicity,
hydrogen
bonding
capacity.
This
chapter
will
provide
brief
overview
bioactivities
derivatives.
Language: Английский