Nature-Inspired Micro/Nano-Structured Antibacterial Surfaces

Molecules, Journal Year: 2024, Volume and Issue: 29(9), P. 1906 - 1906

Published: April 23, 2024

The problem of bacterial resistance has become more and common with improvements in health care. Worryingly, the misuse antibiotics leads to an increase multidrug development new virtually stalled. These challenges have prompted need combat infections use radically different approaches. Taking lessons from exciting properties micro-/nano-natural-patterned surfaces, which can destroy cellular integrity, construction artificial surfaces mimic natural functions provides opportunities for innovation biomedicine. Due diversity functional inspired by a wide range applications healthcare. Nature-inspired surface structures emerged as effective durable strategy prevent infection, opening way alleviate drug resistance. present situation bactericidal antifouling biomimetic micro-/nano-structures is briefly reviewed. In addition, these innovative nature-inspired methods are used manufacture variety achieve extraordinary antibacterial properties. particular, physical effect mechanisms chemical groups, small molecules, ions discussed, well current future micro-/nano-surfaces. Current directions also discussed at end. future, controlling their subsequent will lead offering great potential

Language: Английский

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Copper(II) carboxylate complexes inhibit Staphylococcus aureus biofilm formation by targeting extracellular proteins

Journal of Inorganic Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 112835 - 112835

Published: Jan. 1, 2025

Language: Английский

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An insight on the powerful of bacterial quorum sensing inhibition

European Journal of Clinical Microbiology & Infectious Diseases, Journal Year: 2024, Volume and Issue: 43(11), P. 2071 - 2081

Published: Aug. 19, 2024

Abstract Bacteria have their own language through which they communicate with one another like all higher organisms. So, many researchers are working hard to identify and comprehend the components of this bacterial communication, known as quorum sensing (QS). In sensing, bacteria use signaling molecules called autoinducers (AIs) exchange information. Many natural compounds extraction techniques been intensively studied disrupt examine effectiveness for pathogenesis control. Quorum inhibitors can interfere QS block action AI molecules. Recent research indicates that (QSIs) quenching enzymes (QQEs) show great promise in reducing pathogenicity inhibiting biofilm synthesis. addition, QQEs QSIs experimental animal models was demonstrated. These taken into account development innovative medical devices, such dressings catheters, prevent infections. The present review highlights aspect a prospective vision its application.

Language: Английский

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Carbon-Dots-Mediated Improvement of Antimicrobial Activity of Natural Products

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(36), P. 47257 - 47269

Published: Aug. 31, 2024

The development of new microbicidal compounds has become a top priority due to the emergence and spread drug-resistant pathogenic microbes. In this study, blue-emitting positively charged carbon dots (CDs), called Du-CDs, were fabricated for first time utilizing natural product extract endophyte Diaporthe unshiuensis YSP3 as raw material through one-step solvothermal method, which possessed varied functional groups including amino, carboxyl, hydroxyl, sulfite groups. Interestingly, Du-CDs exhibited notably enhanced antimicrobial activities toward both bacteria fungi compared YSP3, with low minimum inhibitory concentrations. Moreover, significantly inhibited formation biofilms. bound microbial cell surface via electronic interaction or hydrophobic entered cells distributed fully inside cells. caused membrane damage and/or division cycle interruption, resulting in death. an improved effect accelerated wound healing ability good biocompatibility mouse model. Overall, we demonstrate that CDs from fungal products presents promising potential means develop novel agents great fluorescence, microbiocidal capacity, biosafety combating infections.

Language: Английский

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Efficacy of different microbial synthesized silver nanoparticles alone and in combination in single- and multi-species of Candida albicans and Pseudomonas aeruginosa biofilm inhibition and in downregulation of the HWP1 and PELA gene expression

Materials Today Communications, Journal Year: 2025, Volume and Issue: 42, P. 111507 - 111507

Published: Jan. 1, 2025

Language: Английский

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Antimicrobial Blue Light Reduces Human-Wound Pathogens’ Resistance to Tetracycline-Class Antibiotics in Biofilms

Cells, Journal Year: 2025, Volume and Issue: 14(3), P. 219 - 219

Published: Feb. 4, 2025

Biofilms contribute to chronic infections and the development of antimicrobial resistance (AMR). We are developing an blue light (aBL) device reduce bacterial bioburden in wounds decrease reliance on systemic antibiotics. aBL induces generation reactive oxygen species (ROS) through photoexcitation endogenous chromophores, causing damage death. This study explores combination tetracyclines (TCs) with for treatment biofilm vitro. Tetracyclines (TCs), including second-generation minocycline (MC), doxycycline (DOCT), third-generation agents omadacycline (OM) tigecycline (TG), were evaluated their ability enhance bactericidal effects ROS production during abiotic biofilm. TCs tested under dark conditions varying parameters against biofilms methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa (PA), Escherichia coli (E. coli). Results showed that alone ineffective these cultures. However, when combined either before or after TC treatment, significant enhancement microbicidal activity was observed. When is added TCs, there equivalent effect, indicating primary action not as photosensitizers. These findings suggest can significantly potentially offering a new effective approach treating biofilm-associated combating AMR applicable.

Language: Английский

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Olive Tree Twigs as an Attractive Green Source of Antioxidant and Antibiofilm Biomolecules

Processes, Journal Year: 2025, Volume and Issue: 13(2), P. 559 - 559

Published: Feb. 17, 2025

Biofilms represent complex three-dimensional microbial communities that can harbor strains highly resistant to antimicrobial agents. These structures, which form on both biotic and abiotic surfaces, are associated with food spoilage increased complications in hospitalized patients. Consequently, there is significant interest developing novel biofilm infection control strategies, particularly those focusing natural molecules dual antibiofilm properties. In this study, olive tree twigs from three varieties of Olea europea chemlal (CH), Azeradj (AZ), wild-type europaea sylvestris (W) were collected the Kabylia region Algeria. The samples underwent systematic extraction evaluated for their antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, properties via disk diffusion minimum inhibitory concentration (MIC), capabilities. Results demonstrated twig extracts exhibited substantial antibacterial potential. activity, measured through DPPH scavenging, showed IC50 values ranging 38.12 ± 1.52 µg/mL 148.7 1.23 µg/mL. When tested against six pathogenic bacterial strains, including ATCC reference milk isolates, MIC ranged 1.18 mg/mL 4.71 mg/mL. Notably, sub-inhibitory concentrations significantly reduced formation across most inhibition rates varying 21% 90.43%. effectiveness was dependent strain, variety, extract used. Statistical analysis confirmed significance these results (p < 0.05). Given antioxidant, antibacterial, extracts, they show promise further development as surface disinfectants potential applications safety control. Additional research warranted fully characterize mechanisms action optimize practical applications.

Language: Английский

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Design and synthesis of new 1,3,4-thiadiazoles as antimicrobial and antibiofilm agents

Zeitschrift für Naturforschung C, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract This study assessed the in vitro antibacterial and antibiofilm properties of new 1,3,4-thiadiazole derivatives. 1 H NMR 13 C analyses were employed to confirm structure synthesized compounds, characterization is followed by assessments their efficacy against Bacillus subtilis NRRL B478, Staphylococcus aureus ATCC 29213, Escherichia coli 25922, Pseudomonas aeruginosa 27853, as well for antifungal activity Candida albicans 90028 krusei 6258, using broth microdilution method. Notably, among tested compound 4a exhibited highest antimicrobial activity, with a minimal inhibitory concentration 125 μg/mL P. 27853 significant achieving 94 %, 98 % 100 biofilm inhibition at 250, 500 1,000 μg/mL, respectively. Besides, 4h achieved 81 89 S. 29213 respectively, displayed potent this bacterium. Finally, theoretical ADME compounds - analyzed calculations. has consolidated base development agents advanced our understanding potential mode action biofilm-associated infections.

Language: Английский

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Chronic suppurative otitis media: disrupted host-microbial interactions and immune dysregulation

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 6, 2025

Recent research has uncovered new mechanisms that disrupt the balance between host and microbes in middle ear, potentially leading to dysbiosis chronic suppurative otitis media (CSOM). Dysbiotic microbial communities, including core pathogens such as persister cells, are recognized for displaying cooperative virulence. These communities not only evade host’s immune defenses but also promote inflammation leads tissue damage. This uncontrolled disorder pathogen proliferation, causing hearing loss systemic complications. In this discussion, we examine emerging paradigms study of CSOM could provide insights into other polymicrobial inflammatory diseases. Additionally, underscore critical knowledge gaps essential developing a comprehensive understanding how interact with both innate adaptive systems trigger maintain CSOM.

Language: Английский

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Progress in Pathogenesis and Treatment of Protracted Bacterial Bronchitis in Children

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(03), P. 709 - 715

Published: Jan. 1, 2025

Language: Английский

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